二甲基砜的生物学功能及其在畜禽生产中的应用前景
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摘要
二甲基砜是一种天然存在于自然界中的含硫有机化合物,具有抗炎、抗氧化、抗癌、预防疾病、增强机体免疫力等作用,被广泛用于保健功能和医疗用途,对于维持人和动物机体的健康发挥着重要作用,在动物的健康养殖中具有广阔的应用前景。本文综述了二甲基砜的理化性质、吸收与代谢以及生物学功能与相关机制,以期为其在动物生产中的应用提供参考依据。
Methylsulfonylmethane is a sulfur-containing organic compound naturally occurring in nature. It has anti-inflammatory,anti-oxidant,anti-cancer,prevent disease and enhance the body 's immunity effects. It is widely used in health care functions and medical applications for the maintenance of human and animal organisms health,plays an important role and has broad application prospects in the healthy breeding of animals.This paper reviews the physicochemical properties,absorption and metabolism,and biological functions and related mechanisms of methylsulfonylmethane,in order to provide reference for its application in animal production.[Chinese Journal of Animal Nutrition,2019,31(7):3031-3038]
Methylsulfonylmethane is a sulfur-containing organic compound naturally occurring in nature. It has anti-inflammatory,anti-oxidant,anti-cancer,prevent disease and enhance the body 's immunity effects. It is widely used in health care functions and medical applications for the maintenance of human and animal organisms health,plays an important role and has broad application prospects in the healthy breeding of animals.This paper reviews the physicochemical properties,absorption and metabolism,and biological functions and related mechanisms of methylsulfonylmethane,in order to provide reference for its application in animal production.[Chinese Journal of Animal Nutrition,2019,31(7):3031-3038]
引文
[1] RICHMOND V L. Incorporation of methylsulfonylmethane sulfur into guinea pig serum proteins[J].Life Sciences,1986,39(3):263-268.
[2] HERSCHLER R J. Methylsulfonylmethane and methods of use:US,US4296130[P].1981-10-20.
[3] BARRAGER E,SCHAUSS A G.Methylsulfonylmethane as a treatment for seasonal allergic rhinitis:additional data on pollen counts and symptom questionnaire[J]. Journal of Alternative and Complementary Medicine,2003,9(1):15-16.
[4] COZEANC,COZEAN J,BENJAMIN R,et al. Dimethyl sulfoxide(DMSO)and methylsulfonylmethane(MSM)formulations to treat osteoarthritis:EP2493314[P].2012-09-05.
[5] EZAKIJ,HASHIMOTO M,HOSOKAWAY,et al.Assessment of safety and efficacy of methylsulfonylmethane on bone andknee joints in osteoarthritis animal model[J]. Journal of Bone and Mineral Metabolism,2013,31(1):16-25.
[6] VAN DER MERWE M,BLOOMER R J. The influence of methylsulfonylmethane on inflammation-associated cytokine release before and following strenuous exercise[J]. Journal of Sports Medicine,2016,2016:7498359.
[7] CHILDS S J.Dimethyl sulfone(DMSO2)in the treatment of interstitial cystitis[J].The Urologic Clinics of North America,1994,21(1):85-88.
[8] JOUNG Y H,NA Y M,YOO Y B,et al.Combination of AG490,a Jak2 inhibitor,and methylsulfonylmethane synergistically suppresses bladder tumor growth via the Jak2/STAT3 pathway[J].International Journal of Oncology,2014,44(3):883-895.
[9] PARCELL S. Sulfur in human nutrition and applications in medicine[J].Alternative Medicine ReviewA,2002,7(1):22-44.
[10] LIEMD A,GHO C C,GHO B C,et al.The tyrosine phosphatase inhibitor bis(maltolato)oxovanadium attenuates myocardial reperfusion injury by opening ATP-sensitive potassium channels[J].Journal of Pharmacology and Experimental Therapeutics,2004,309(3):1256-1262.
[11] OBATA T. Adenosine production and its interaction with protection of ischemic and reperfusion injury of the myocardium[J]. Life Sciences,2002,71(18):2083-2103.
[12]刘惠芳.半胱胺、二甲基砜和天然植物提取物对肉鸭的促生长作用及其机理研究[D].博士学位论文.成都:四川农业大学,2009.
[13] LIN A,NGUY C H,SHIC F,et al. Accumulation of methylsulfonylmethane in the human brain:identification by multinuclear magnetic resonance spectroscopy[J].Toxicology Letters,2001,123(2/3):169-177.
[14] WONG T,BLOOMER R J,BENJAMIN R L,et al.Small intestinal absorption of methylsulfonylmethane(MSM)and accumulation of the sulfur moiety in selected tissues of mice[J].Nutrients,2018,10(1):E19.
[15] METGES C C,EBERHARD M,PETZKE K J. Synthesis and absorption of intestinal microbial lysine in humans and non-ruminant animals and impact on human estimated average requirement of dietary lysine[J]. Current Opinion in Clinical Nutrition and Metabolic Care,2006,9(1):37-41.
[16] CARBONERO F,BENEFIEL A C,ALIZADEHGHAMSARI A H,et al. Microbial pathways incolonic sulfur metabolism and links with health and disease[J].Frontiers in Physiology,2012,3:448.
[17] MAGNUSON B A,APPLETON J,AMES G B.Pharmacokinetics and distribution of[35S]methylsulfonylmethane following oral administration to rats[J].Journal of Agricultural and Food Chemistry,2007,55(3):1033-1038.
[18] TOBISAWA Y,IMAI Y,FUKUDA M,et al.Sulfation of colonic mucins by N-acetylglucosamine 6-o-sulfotransferase-2 and its protective function in experimental colitis in mice[J]. Journal of Biological Chemistry,2011,285(9):6750-6760.
[19] LAYMAN D L,JACOB S W.The absorption,metabolism and excretion of dimethyl sulfoxide by rhesus monkeys[J]. Life Sciences,1985,37(25):2431-2437.
[20] MARAN G,MUOZ-ESCASSI B,MANLEY W,et al. The effect of methyl sulphonyl methane supplementation on biomarkers of oxidative stress in sport horses following jumping exercise[J]. Acta Veterinaria Scandinavica,2008,50:45.
[21] BEILKE MA,COLLINS-LECH C,SOHNLE P G.Effects of dimethyl sulfoxide on the oxidative function of human neutrophils[J]. Journal of Laboratory and Clinical Medicine,1987,110(1):91-96.
[22] KIMS H,SMITH A J,TAN J,et al.MSMameliorates HIV-1 tat induced neuronal oxidative stress via rebalance of the glutathione cycle[J]. American Journal of Translational Research,2015,7(2):328-338.
[23] LAWRENCE T.The nuclear factor NF-κB pathway in inflammation[J]. Cold Spring Harbor Perspectives in Biology,2009,1(6):a001651.
[24] KIMY H,KIMD H,LIMH,et al.The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages[J].Biological and Pharmaceutical Bulletin,2009,32(4):651-656.
[25] DUNN J D,ALVAREZ L A J,ZHANG X Z,et al.Reactive oxygen species and mitochondria:a nexus of cellular homeostasis[J]. Redox Biology,2015,6:472-485.
[26] AHN H,KIMJ,LEE MJ,et al.Methylsulfonylmethane inhibits NLRP3 inflammasome activation[J]. Cytokine,2015,71(2):223-231.
[27] KASTL L,SAUER S W,RUPPERT T,et al. TNF-αmediates mitochondrial uncoupling and enhances ROS-dependent cell migration via NF-κB activation in liver cells[J].FEBS Letters,2014,588(1):175-183.
[28] FU L X,LIAN Q W,PAN J D,et al. JAK2 tyrosine kinase inhibitor AG490 suppresses cell growth and invasion of gallbladder cancer cells via inhibition of JAK2/STAT3 signaling[J]. Journal of Biological Regulators&Homeostatic Agents,2017,31(1):51.
[29] NIPIN S P,DARVIN P,YOO Y B,et al.The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts[J]. BMC Cancer,2015,15:474.
[30] LIME J,HONG D Y,PARK J H,et al.Methylsulfonylmethane suppresses breast cancer growth by downregulating STAT3 and STAT5b pathways[J]. PLoS One,2012,7(4):e33361.
[31] REDZA-DUTORDOIR M,AVERILL-BATES D A.Activation of apoptosis signalling pathways by reactive oxygen species[J]. Biochimica et Biophysica Acta:Molecular Cell Research,2016,1863(12):2977-2992.
[32] MANEA A,TANASE L I,RAICU M,et al. Jak/STAT signaling pathway regulates nox1 and nox4-based NADPH oxidase in human aortic smooth muscle cells[J]. Arteriosclerosis,Thrombosis and Vascular Biology,2010,30(1):105-112.
[33] GROSS A.BCL-2 family proteins as regulators of mitochondria metabolism[J]. Biochimica et Biophysica Acta:Bioenergetics,2016,1857(8):1243-1246.
[34] LIU D P,XU Y.p53,oxidative stress,and aging[J].Antioxidants&Redox Signaling,2011,15(6):1669-1678.
[35] KARABAY A Z,AKTAN F,SUNGURO GˇLU A,et al. Methylsulfonylmethane modulates apoptosis of LPS/IFN-γ-activated RAW 264. 7 macrophage-like cells by targeting p53,Bax,Bcl-2,cytochromec and PARP proteins[J]. Immunopharmacology&Immunotoxicology,2014,36(6):379-389.
[36] POMERANTZ J L,BALTIMORE A D.Two pathways to NF-κB[J].Molecular Cell,2002,10(4):693-695.
[37] JOUNG Y H,DARVIN P,KANG D Y,et al.Methylsulfonylmethane inhibits RANKL-induced osteoclastogenesis in BMMs by suppressing NF-κB and STAT3activities[J].PLoS One,2016,11(7):e0159891.
[38] OSHIMA Y,AMIEL D,THEODOSAKIS J. 213 the effect of distilled methylsulfonylmethane(MSM)on human chondrocytes in vitro[J]. Osteoarthritis and Cartilage,2007,15(15):C123.
[39] TOUSOULIS D,KAMPOLI A M,COSTAS T N P,et al.The role of nitric oxide on endothelial function[J].Current Vascular Pharmacology,2012,10(1):4-18.
[40] COLEMAN J W.Nitric oxide:a regulator of mast cell activation and mast cell-mediated inflammation[J].Clinical&Experimental Immunology,2010,129(1):4-10.
[41] HE Y,HARA H,NEZ G. Mechanism and regulation of NLRP3 inflammasome activation[J].Trends in Biochemical Sciences,2016,41(12):1012-1021.
[42] MARTINON F. Detection of immune danger signals by NALP3[J].Journal of leukocyte Biology,2008,83(3):507-511.
[43]余伟,祝曙光,陆少君,等.二甲基砜对小鼠抗炎作用及免疫功能的影响[J].海南医学院学报,2018,24(9):899-901.
[44] AMIRSHAHROKHI K, BOHLOOLI S, CHINIFROUSH MM. The effect of methylsulfonylmethane on the experimental colitis in the rat[J]. Toxicology and Applied Pharmacology,2011,253(3):197-202.
[45] KARABAY A Z,KOC A,OZKAN T,et al. Methylsulfonylmethane induces p53 independent apoptosis in hct-116 colon cancer cells[J]. International Journal of Molecular Sciences,2016,17(7):1123.
[46] CARON J M,MONTEAGUDO L,SANDERS M,et al. Methyl sulfone manifests anticancer activity in a metastatic murine breast cancer cell line and in human breast cancer tissue-part 2:human breast cancer tissue[J].Chemotherapy,2013,59(1):24-34.
[47] SP N,DARVIN P,YOO Y B,et al.The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts[J].BMC Cancer,2015,15:474.
[48] JAFARI N,BOHLOOLI S,MOHAMMADI S,et al.Cytotoxicity of methylsulfonylmethane on gastrointestinal(AGS,HepG2,and KEYSE-30)cancer cell lines[J].Journal of Gastrointestinal Cancer,2012,43(3):420-425.
[49] KIMJ H,SHIN H J,HA H L,et al. Methylsulfonylmethane suppresses hepatic tumor development through activation of apoptosis[J]. World Journal of Hepatology,2014,6(2):98-106.
[50] KARABAY A Z,KOCA,OZKAN T,et al.Methylsulfonylmethane induces p53 independent apoptosis in hct-116 colon cancer cells[J]. International Journal of Molecular Sciences,2016,17(7):1123.
[51] PARK D J,THOMAS N J,YOON C,et al. Vascular endothelial growth factor a inhibition in gastric cancer[J].Gastric Cancer,2015,18(1):33-42.
[52] CARON MI,CARON MI. Methyl sulfone blocked multiple hypoxia-and non-hypoxia-induced metastatic targets in breast cancer cells and melanoma cells[J].PLoS One,2015,10(11):e0141565.
[53] WITHEE E D,TIPPENS K M,DEHEN R,et al.Effects of methylsulfonylmethane(MSM)on exercise-induced oxidative stress,muscle damage,and pain following a half-marathon:a double-blind,randomized,placebo-controlled trial[J]. Journal of the International Society of Sports Nutrition,2017,14:24.
[54] KAUFMANNS H,HENGARTNER MO.Programmed cell death:alive and well in the newmillennium[J].Trends in Cell Biology,2001,11(12):526-534.
[55] NAGY G,SZARKA A,LOTZ G,et al.BGP-15 inhibits caspase-independent programmed cell death in acetaminophen-induced liver injury[J]. Toxicology and Applied Pharmacology,2010,243(1):96-103.
[56] RAMOUTAR R R,BRUMAGHIMJ L. Antioxidant and anticancer properties and mechanisms of inorganic selenium,oxo-sulfur,and oxo-selenium compounds[J].Cell Biochemistry and Biophysics,2010,58(1):1-23.
[57] MORTON J I,SIEGEL B V.Effects of oral dimethyl sulfoxide and dimethyl sulfone on murine autoimmune lymphoproliferative disease[J]. Experimental Biology and Medicine,1986,183(2):227-230.
[58] CHO J H,MIN B J,KWON O S,et al. Effects of MSM(methyl sulfonyl methane)supplementation on growth performance and digestibility of Ca and N in pigs[J]. Journal of the Korean Society of Food Science and Nutrition,2005,34(3):361-365.
[59]范京辉.MSM对肉鸡生长及脂肪代谢影响[C].//第十四届全国家禽科学学术讨论会论文集.哈尔滨:中国畜牧兽医学会,2009:4.
[60]刘惠芳,周安国.植物提取物、半胱胺和二甲基砜对肉鸭生产性能和屠宰性能的影响[J].天然产物研究与开发,2008,20(2):302-306.
[61]严梦,刘惠芳,王之盛,等.天然植物提取物、半胱胺和二甲基砜对肉鸭生长性能和屠宰性能的影响[J].四川农业大学学报,2006,24(4):439-443.
[62] BENJAMIN R LVARELMAN J,KELLER A L. Use of methylsulfonylmethane(MSM)to modulate inhibit microbial activity:US,20130065967[P]. 2013-03-14.
[63] JIAO Y,PARK J H,KIMY M,et al.Effects of dietary methyl sulfonyl methane(MSM)supplementation on growth performance,nutrient digestibility,meat quality,excreta microbiota,excreta gas emission,and blood profiles in broilers[J]. Poultry Science,2017,96(7):2168-2175.
[2] HERSCHLER R J. Methylsulfonylmethane and methods of use:US,US4296130[P].1981-10-20.
[3] BARRAGER E,SCHAUSS A G.Methylsulfonylmethane as a treatment for seasonal allergic rhinitis:additional data on pollen counts and symptom questionnaire[J]. Journal of Alternative and Complementary Medicine,2003,9(1):15-16.
[4] COZEANC,COZEAN J,BENJAMIN R,et al. Dimethyl sulfoxide(DMSO)and methylsulfonylmethane(MSM)formulations to treat osteoarthritis:EP2493314[P].2012-09-05.
[5] EZAKIJ,HASHIMOTO M,HOSOKAWAY,et al.Assessment of safety and efficacy of methylsulfonylmethane on bone andknee joints in osteoarthritis animal model[J]. Journal of Bone and Mineral Metabolism,2013,31(1):16-25.
[6] VAN DER MERWE M,BLOOMER R J. The influence of methylsulfonylmethane on inflammation-associated cytokine release before and following strenuous exercise[J]. Journal of Sports Medicine,2016,2016:7498359.
[7] CHILDS S J.Dimethyl sulfone(DMSO2)in the treatment of interstitial cystitis[J].The Urologic Clinics of North America,1994,21(1):85-88.
[8] JOUNG Y H,NA Y M,YOO Y B,et al.Combination of AG490,a Jak2 inhibitor,and methylsulfonylmethane synergistically suppresses bladder tumor growth via the Jak2/STAT3 pathway[J].International Journal of Oncology,2014,44(3):883-895.
[9] PARCELL S. Sulfur in human nutrition and applications in medicine[J].Alternative Medicine ReviewA,2002,7(1):22-44.
[10] LIEMD A,GHO C C,GHO B C,et al.The tyrosine phosphatase inhibitor bis(maltolato)oxovanadium attenuates myocardial reperfusion injury by opening ATP-sensitive potassium channels[J].Journal of Pharmacology and Experimental Therapeutics,2004,309(3):1256-1262.
[11] OBATA T. Adenosine production and its interaction with protection of ischemic and reperfusion injury of the myocardium[J]. Life Sciences,2002,71(18):2083-2103.
[12]刘惠芳.半胱胺、二甲基砜和天然植物提取物对肉鸭的促生长作用及其机理研究[D].博士学位论文.成都:四川农业大学,2009.
[13] LIN A,NGUY C H,SHIC F,et al. Accumulation of methylsulfonylmethane in the human brain:identification by multinuclear magnetic resonance spectroscopy[J].Toxicology Letters,2001,123(2/3):169-177.
[14] WONG T,BLOOMER R J,BENJAMIN R L,et al.Small intestinal absorption of methylsulfonylmethane(MSM)and accumulation of the sulfur moiety in selected tissues of mice[J].Nutrients,2018,10(1):E19.
[15] METGES C C,EBERHARD M,PETZKE K J. Synthesis and absorption of intestinal microbial lysine in humans and non-ruminant animals and impact on human estimated average requirement of dietary lysine[J]. Current Opinion in Clinical Nutrition and Metabolic Care,2006,9(1):37-41.
[16] CARBONERO F,BENEFIEL A C,ALIZADEHGHAMSARI A H,et al. Microbial pathways incolonic sulfur metabolism and links with health and disease[J].Frontiers in Physiology,2012,3:448.
[17] MAGNUSON B A,APPLETON J,AMES G B.Pharmacokinetics and distribution of[35S]methylsulfonylmethane following oral administration to rats[J].Journal of Agricultural and Food Chemistry,2007,55(3):1033-1038.
[18] TOBISAWA Y,IMAI Y,FUKUDA M,et al.Sulfation of colonic mucins by N-acetylglucosamine 6-o-sulfotransferase-2 and its protective function in experimental colitis in mice[J]. Journal of Biological Chemistry,2011,285(9):6750-6760.
[19] LAYMAN D L,JACOB S W.The absorption,metabolism and excretion of dimethyl sulfoxide by rhesus monkeys[J]. Life Sciences,1985,37(25):2431-2437.
[20] MARAN G,MUOZ-ESCASSI B,MANLEY W,et al. The effect of methyl sulphonyl methane supplementation on biomarkers of oxidative stress in sport horses following jumping exercise[J]. Acta Veterinaria Scandinavica,2008,50:45.
[21] BEILKE MA,COLLINS-LECH C,SOHNLE P G.Effects of dimethyl sulfoxide on the oxidative function of human neutrophils[J]. Journal of Laboratory and Clinical Medicine,1987,110(1):91-96.
[22] KIMS H,SMITH A J,TAN J,et al.MSMameliorates HIV-1 tat induced neuronal oxidative stress via rebalance of the glutathione cycle[J]. American Journal of Translational Research,2015,7(2):328-338.
[23] LAWRENCE T.The nuclear factor NF-κB pathway in inflammation[J]. Cold Spring Harbor Perspectives in Biology,2009,1(6):a001651.
[24] KIMY H,KIMD H,LIMH,et al.The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages[J].Biological and Pharmaceutical Bulletin,2009,32(4):651-656.
[25] DUNN J D,ALVAREZ L A J,ZHANG X Z,et al.Reactive oxygen species and mitochondria:a nexus of cellular homeostasis[J]. Redox Biology,2015,6:472-485.
[26] AHN H,KIMJ,LEE MJ,et al.Methylsulfonylmethane inhibits NLRP3 inflammasome activation[J]. Cytokine,2015,71(2):223-231.
[27] KASTL L,SAUER S W,RUPPERT T,et al. TNF-αmediates mitochondrial uncoupling and enhances ROS-dependent cell migration via NF-κB activation in liver cells[J].FEBS Letters,2014,588(1):175-183.
[28] FU L X,LIAN Q W,PAN J D,et al. JAK2 tyrosine kinase inhibitor AG490 suppresses cell growth and invasion of gallbladder cancer cells via inhibition of JAK2/STAT3 signaling[J]. Journal of Biological Regulators&Homeostatic Agents,2017,31(1):51.
[29] NIPIN S P,DARVIN P,YOO Y B,et al.The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts[J]. BMC Cancer,2015,15:474.
[30] LIME J,HONG D Y,PARK J H,et al.Methylsulfonylmethane suppresses breast cancer growth by downregulating STAT3 and STAT5b pathways[J]. PLoS One,2012,7(4):e33361.
[31] REDZA-DUTORDOIR M,AVERILL-BATES D A.Activation of apoptosis signalling pathways by reactive oxygen species[J]. Biochimica et Biophysica Acta:Molecular Cell Research,2016,1863(12):2977-2992.
[32] MANEA A,TANASE L I,RAICU M,et al. Jak/STAT signaling pathway regulates nox1 and nox4-based NADPH oxidase in human aortic smooth muscle cells[J]. Arteriosclerosis,Thrombosis and Vascular Biology,2010,30(1):105-112.
[33] GROSS A.BCL-2 family proteins as regulators of mitochondria metabolism[J]. Biochimica et Biophysica Acta:Bioenergetics,2016,1857(8):1243-1246.
[34] LIU D P,XU Y.p53,oxidative stress,and aging[J].Antioxidants&Redox Signaling,2011,15(6):1669-1678.
[35] KARABAY A Z,AKTAN F,SUNGURO GˇLU A,et al. Methylsulfonylmethane modulates apoptosis of LPS/IFN-γ-activated RAW 264. 7 macrophage-like cells by targeting p53,Bax,Bcl-2,cytochromec and PARP proteins[J]. Immunopharmacology&Immunotoxicology,2014,36(6):379-389.
[36] POMERANTZ J L,BALTIMORE A D.Two pathways to NF-κB[J].Molecular Cell,2002,10(4):693-695.
[37] JOUNG Y H,DARVIN P,KANG D Y,et al.Methylsulfonylmethane inhibits RANKL-induced osteoclastogenesis in BMMs by suppressing NF-κB and STAT3activities[J].PLoS One,2016,11(7):e0159891.
[38] OSHIMA Y,AMIEL D,THEODOSAKIS J. 213 the effect of distilled methylsulfonylmethane(MSM)on human chondrocytes in vitro[J]. Osteoarthritis and Cartilage,2007,15(15):C123.
[39] TOUSOULIS D,KAMPOLI A M,COSTAS T N P,et al.The role of nitric oxide on endothelial function[J].Current Vascular Pharmacology,2012,10(1):4-18.
[40] COLEMAN J W.Nitric oxide:a regulator of mast cell activation and mast cell-mediated inflammation[J].Clinical&Experimental Immunology,2010,129(1):4-10.
[41] HE Y,HARA H,NEZ G. Mechanism and regulation of NLRP3 inflammasome activation[J].Trends in Biochemical Sciences,2016,41(12):1012-1021.
[42] MARTINON F. Detection of immune danger signals by NALP3[J].Journal of leukocyte Biology,2008,83(3):507-511.
[43]余伟,祝曙光,陆少君,等.二甲基砜对小鼠抗炎作用及免疫功能的影响[J].海南医学院学报,2018,24(9):899-901.
[44] AMIRSHAHROKHI K, BOHLOOLI S, CHINIFROUSH MM. The effect of methylsulfonylmethane on the experimental colitis in the rat[J]. Toxicology and Applied Pharmacology,2011,253(3):197-202.
[45] KARABAY A Z,KOC A,OZKAN T,et al. Methylsulfonylmethane induces p53 independent apoptosis in hct-116 colon cancer cells[J]. International Journal of Molecular Sciences,2016,17(7):1123.
[46] CARON J M,MONTEAGUDO L,SANDERS M,et al. Methyl sulfone manifests anticancer activity in a metastatic murine breast cancer cell line and in human breast cancer tissue-part 2:human breast cancer tissue[J].Chemotherapy,2013,59(1):24-34.
[47] SP N,DARVIN P,YOO Y B,et al.The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts[J].BMC Cancer,2015,15:474.
[48] JAFARI N,BOHLOOLI S,MOHAMMADI S,et al.Cytotoxicity of methylsulfonylmethane on gastrointestinal(AGS,HepG2,and KEYSE-30)cancer cell lines[J].Journal of Gastrointestinal Cancer,2012,43(3):420-425.
[49] KIMJ H,SHIN H J,HA H L,et al. Methylsulfonylmethane suppresses hepatic tumor development through activation of apoptosis[J]. World Journal of Hepatology,2014,6(2):98-106.
[50] KARABAY A Z,KOCA,OZKAN T,et al.Methylsulfonylmethane induces p53 independent apoptosis in hct-116 colon cancer cells[J]. International Journal of Molecular Sciences,2016,17(7):1123.
[51] PARK D J,THOMAS N J,YOON C,et al. Vascular endothelial growth factor a inhibition in gastric cancer[J].Gastric Cancer,2015,18(1):33-42.
[52] CARON MI,CARON MI. Methyl sulfone blocked multiple hypoxia-and non-hypoxia-induced metastatic targets in breast cancer cells and melanoma cells[J].PLoS One,2015,10(11):e0141565.
[53] WITHEE E D,TIPPENS K M,DEHEN R,et al.Effects of methylsulfonylmethane(MSM)on exercise-induced oxidative stress,muscle damage,and pain following a half-marathon:a double-blind,randomized,placebo-controlled trial[J]. Journal of the International Society of Sports Nutrition,2017,14:24.
[54] KAUFMANNS H,HENGARTNER MO.Programmed cell death:alive and well in the newmillennium[J].Trends in Cell Biology,2001,11(12):526-534.
[55] NAGY G,SZARKA A,LOTZ G,et al.BGP-15 inhibits caspase-independent programmed cell death in acetaminophen-induced liver injury[J]. Toxicology and Applied Pharmacology,2010,243(1):96-103.
[56] RAMOUTAR R R,BRUMAGHIMJ L. Antioxidant and anticancer properties and mechanisms of inorganic selenium,oxo-sulfur,and oxo-selenium compounds[J].Cell Biochemistry and Biophysics,2010,58(1):1-23.
[57] MORTON J I,SIEGEL B V.Effects of oral dimethyl sulfoxide and dimethyl sulfone on murine autoimmune lymphoproliferative disease[J]. Experimental Biology and Medicine,1986,183(2):227-230.
[58] CHO J H,MIN B J,KWON O S,et al. Effects of MSM(methyl sulfonyl methane)supplementation on growth performance and digestibility of Ca and N in pigs[J]. Journal of the Korean Society of Food Science and Nutrition,2005,34(3):361-365.
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