一种制备嘧菌酯及其中间体的高效催化剂

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英文篇名：An Efficient Catalyst for the Synthesis of Azoxystrobin and Its Intermediate 作者：范朝辉 ; 王利超 ; 高永民 ; 赵娜 ; 张耀林 ; 李立华 ; 史秀肖 ; 贾成国 英文作者：FAN Zhao-hui;WANG Li-chao;GAO Yong-min;ZHAO Na;ZHANG Yao-lin;LI Li-hua;SHI Xiu-xiao;JIA Cheng-guo;Hebei Veyong Bio-chemical Co.,Ltd.; 关键词：嘧菌酯 ; 1-氮杂双环[3.2.1]辛烷-6-醇 ; 合成 ; 催化剂 英文关键词：azoxystrobin;;1-azabicyclo[3.2.1]-6-octanol;;synthesis;;catalyst 中文刊名：NYZZ 英文刊名：Agrochemicals 机构：河北威远生物化工有限公司; 出版日期：2019-07-10 出版单位：农药 年：2019 期：v.58 语种：中文; 页：NYZZ201907007 页数：4 CN：07 ISSN：21-1210/TQ 分类号：20-23

摘要

[目的]开发一种制备嘧菌酯及其中间体2-(2-((6-氯嘧啶-4-基)氧基)苯基)-3,3-二甲氧基丙烯酸酯的新型催化剂。[方法]以哌啶-3-甲酸乙酯为初始原料,经烷基化、迪克曼缩合、脱羧、还原得到1-氮杂双环[3.2.1]辛烷-6-醇,并以该化合物为催化剂制备嘧菌酯及其中间体。[结果]以哌啶-3-甲酸乙酯为初始原料,经4步反应制备1-氮杂双环[3.2.1]辛烷-6-醇,总收率达到71.1%。以该化合物为催化剂,高收率的合成了嘧菌酯及其中间体。[结论]1-氮杂双环[3.2.1]辛烷-6-醇可以高效的催化嘧菌酯及其中间体的制备反应,为嘧菌酯及其中间体的制备提供了新的催化剂。
        [Aims] A new efficient catalyst was developed for the preparation of azoxystrobin and its intermediate methyl 2-(2-(6-chloropyridine-4-yloxy)phenyl)-3,3-dimethoxypropanoate.[Methods] Using ethyl 3-piperidinecarboxylate as starting material,1-azabicyclo[3.2.1]-6-octanol was obtained by alkylation,Dickman condensation,decarboxylation,and reduction.The compound was tested as catalyst for the preparation of azoxystrobin and its intermediate.[Results] 1-Azabicyclo [3.2.1]octan-6-ol was prepared in total yield of 71.1% through four steps.The compound was found to be an efficient catalyst for the preparation of azoxystrobin and its intermediate.[Conclusions] 1-Azabicyclo[3.2.1]octan-6-ol as a new efficient catalyst has been used for the synthesis of azoxystrobin and its intermediate.

引文

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