SOX方案联合小牛脾提取物治疗老年胃癌的效果及对血清反应因子和血清氧调节蛋白水平的影响
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摘要
目的探究替吉奥联合奥沙利铂化疗(SOX)方案联合小牛脾提取物治疗老年胃癌病人的效果及对血清氧调节蛋白(ORP150)和血清反应因子(SRF)水平的影响。方法选取在医院进行治疗的老年胃癌患者86例,按随机数字表法分为对照组和观察组,各43例,对照组给予SOX方案进行治疗,观察组在对照组治疗的基础上静脉滴注小牛脾提取物注射液,连续治疗2个周期,比较2组患者的治疗效、短期生存率、不良反应发生率、ORP150和SRF水平。结果治疗后,观察组有效率为58.14%,明显高于对照组(41.86%)(χ~2=5.301,P=0.021)。观察组患者1年和2年生存率均高于对照组(P<0.05)。治疗期间,观察组胃肠道反应和骨髓抑制发生率明显低于对照组。治疗后,2组患者ORP150和SRF水平均明显下降,但观察组下降更明显(P<0.05)。结论 SOX方案联合小牛脾提取物对老年胃癌患者的治疗效果确切,可有效提高患者短期生存率,降低ORP150和SRF水平,降低胃肠道反应及骨髓抑制发生率,安全性较高。
Objective To explore the effect of oxaliplatin chemotherapy regimen(SOX)combined with calf spleen extract on elderly patients with gastric cancer and its effect on serum reaction factor(SRF)and serum oxygen regulatory protein(ORP150)levels.Methods 86 elderly patients with gastric cancer were selected and divided into control group and observation group according to random digital table method,with 43 cases in each group.The control group was treated with teggio combined with SOX scheme.The observation group was treated with Calf Spleen Extractive Injections on the basis of the control group.The two cycles were continuously treated.The therapeutic effect,short-term survival rate,incidence of adverse reactions,the levels of serum oxygen regulatory protein(ORP150)and serum reactive factor(SRF)were compared between the 2 groups.Results After the treatment,the effective rate of the observation group was 58.14%,which was significantly higher than that of the control group(41.86%)(χ~2=5.301,P=0.021).The 1 year and 2 year survival rate of the observation group were all higher than those of the control group(P<0.05).During the treatment period,the incidence of gastrointestinal reactions and myelosuppression in the observation group was significantly lower than that in the control group.After treatment,the levels of serum oxygen regulatory protein and serum reactive factor were significantly decreased in the 2 groups,but the decrease in the observation group was more significant(P<0.05).Conclusion SOX regimen combined with calf spleen extract is effective in the treatment of elderly patients with gastric cancer.It can effectively improve the short-term survival rate,reduce the level of serum oxygen regulatory protein and serum reaction factor,reduce the incidence of gastrointestinal reaction and bone marrow suppression with high safety.
Objective To explore the effect of oxaliplatin chemotherapy regimen(SOX)combined with calf spleen extract on elderly patients with gastric cancer and its effect on serum reaction factor(SRF)and serum oxygen regulatory protein(ORP150)levels.Methods 86 elderly patients with gastric cancer were selected and divided into control group and observation group according to random digital table method,with 43 cases in each group.The control group was treated with teggio combined with SOX scheme.The observation group was treated with Calf Spleen Extractive Injections on the basis of the control group.The two cycles were continuously treated.The therapeutic effect,short-term survival rate,incidence of adverse reactions,the levels of serum oxygen regulatory protein(ORP150)and serum reactive factor(SRF)were compared between the 2 groups.Results After the treatment,the effective rate of the observation group was 58.14%,which was significantly higher than that of the control group(41.86%)(χ~2=5.301,P=0.021).The 1 year and 2 year survival rate of the observation group were all higher than those of the control group(P<0.05).During the treatment period,the incidence of gastrointestinal reactions and myelosuppression in the observation group was significantly lower than that in the control group.After treatment,the levels of serum oxygen regulatory protein and serum reactive factor were significantly decreased in the 2 groups,but the decrease in the observation group was more significant(P<0.05).Conclusion SOX regimen combined with calf spleen extract is effective in the treatment of elderly patients with gastric cancer.It can effectively improve the short-term survival rate,reduce the level of serum oxygen regulatory protein and serum reaction factor,reduce the incidence of gastrointestinal reaction and bone marrow suppression with high safety.
引文
[1]左婷婷,郑荣寿,曾红梅,等.中国胃癌流行病学现状[J].中国肿瘤临床,2017,44(1):52-58.
[2]巩稳定,田少芳,梁铟,等.逍遥散诱导胃癌细胞凋亡实验研究[J].西北药学杂志,2001,16(6):256-257.
[3]宋杰,陈凤格,赵伟,等.胃癌的发病率现状与治疗研究进展[J].中国慢性病预防与控制,2016,24(9):704-707.
[4]罗湘江,王宁菊,刘明放,等.博尔宁胶囊治疗晚期肝癌、胃癌30例临床观察[J].西北药学杂志,1998,13(6):262.
[5]陶娌娜,张四喜,柯巍,等.小牛脾提取物注射液临床应用分析[J].实用药物与临床,2016,19(2):231-234.
[6]郭闻一,邓文宏,孙荣泽,等.氧调节蛋白ORP150在胃肠道肿瘤患者血清中的水平变化及意义[J].武汉大学学报:医学版,2016,37(2):218-222.
[7]乔娟丽.SRF通过上调肌成纤维细胞分泌SDF1来促进胃癌细胞转移[A].中国抗癌协会肿瘤病因学专业委员会.全国肿瘤流行病学和肿瘤病因学学术会议论文集[C].成都:中华医学会中华预防医学杂志社,2015:94.
[8]刘坤,李国立,范朝刚,等.胃癌原发灶体积改变在胃癌术前化疗疗效评价中的应用价值[J].实用临床医药杂志,2016,20(24):60-62,72.
[9]童流妹,徐惠亮,蒋红良.SOX方案及XELOX方案一线治疗晚期胃癌的临床研究[J].实用肿瘤杂志,2015,30(1):56-59.
[10]宾业鸿,蔡正文,刘汉峰.SOX方案与改良mFOLFOX6方案治疗弥散型进展期胃癌的疗效和安全性比较[J].中国药房,2016,27(21):2903-2906.
[11]王金烁,谢泽新.小牛脾提取物注射液联合化疗用于老年晚期非小细胞肺癌的疗效观察[J].河北医药,2015,37(3):401-403.
[12]李多,胡燕,李冬琼,等.小牛脾提取物注射液联合胸膜腔局部化疗治疗恶性胸腔积液的临床观察[J].中国现代医学杂志,2016,26(23):107-110.
[13]Hu Z Y,Liu X Y,Liu X M,et al.Calf spleen extract alleviates cyclophosphamide-induced leucopenia in mice and inhibits the glycolysis of HL60cells[J].J Chin Pharm Sci,2011,20(2):181-187.
[14]孟玮,史晓宇,张敬,等.小牛脾提取物联合奥沙利铂方案治疗晚期结肠癌的临床观察[J].中国煤炭工业医学杂志,2017,20(7):828-831.
[15]赵敏,张辉,周颖,等.胃癌血清应答因子和血管内皮生长因子受体2的表达及其临床意义[J].肿瘤研究与临床,2016,28(2):112-115.
[16]刘兆君.SRF等胃癌转移相关基因CpG岛甲基化标志物筛选和验证[A].中国抗癌协会肿瘤流行病学专业委员会.全国肿瘤流行病学和肿瘤病因学学术会议论文集[C].承德:中华医学会中华预防医学杂志社,2011:126.
[17]Wang W A,Groenendyk J,Michalak M.Endoplasmic reticulum stress associated responses in cancer[J].Biochim Biophys Acta,2014,1843(10):2143-2149.
[18]高雁艳.氧调节蛋白(ORP150)在蛋白酶体抑制剂诱导甲状腺癌细胞凋亡中的作用[D].沈阳:中国医科大学,2012.
[19]彭浩,杨华伟,宋立伟,等.胃癌患者血清ORP150水平及其临床意义[J].医学研究杂志,2016,45(6):67-69.
[20]魏华.氧化应激诱导间充质干细胞凋亡及磷脂类分子调节血管内皮生长因子分泌研究[D].北京:中国协和医科大学,2010.
[2]巩稳定,田少芳,梁铟,等.逍遥散诱导胃癌细胞凋亡实验研究[J].西北药学杂志,2001,16(6):256-257.
[3]宋杰,陈凤格,赵伟,等.胃癌的发病率现状与治疗研究进展[J].中国慢性病预防与控制,2016,24(9):704-707.
[4]罗湘江,王宁菊,刘明放,等.博尔宁胶囊治疗晚期肝癌、胃癌30例临床观察[J].西北药学杂志,1998,13(6):262.
[5]陶娌娜,张四喜,柯巍,等.小牛脾提取物注射液临床应用分析[J].实用药物与临床,2016,19(2):231-234.
[6]郭闻一,邓文宏,孙荣泽,等.氧调节蛋白ORP150在胃肠道肿瘤患者血清中的水平变化及意义[J].武汉大学学报:医学版,2016,37(2):218-222.
[7]乔娟丽.SRF通过上调肌成纤维细胞分泌SDF1来促进胃癌细胞转移[A].中国抗癌协会肿瘤病因学专业委员会.全国肿瘤流行病学和肿瘤病因学学术会议论文集[C].成都:中华医学会中华预防医学杂志社,2015:94.
[8]刘坤,李国立,范朝刚,等.胃癌原发灶体积改变在胃癌术前化疗疗效评价中的应用价值[J].实用临床医药杂志,2016,20(24):60-62,72.
[9]童流妹,徐惠亮,蒋红良.SOX方案及XELOX方案一线治疗晚期胃癌的临床研究[J].实用肿瘤杂志,2015,30(1):56-59.
[10]宾业鸿,蔡正文,刘汉峰.SOX方案与改良mFOLFOX6方案治疗弥散型进展期胃癌的疗效和安全性比较[J].中国药房,2016,27(21):2903-2906.
[11]王金烁,谢泽新.小牛脾提取物注射液联合化疗用于老年晚期非小细胞肺癌的疗效观察[J].河北医药,2015,37(3):401-403.
[12]李多,胡燕,李冬琼,等.小牛脾提取物注射液联合胸膜腔局部化疗治疗恶性胸腔积液的临床观察[J].中国现代医学杂志,2016,26(23):107-110.
[13]Hu Z Y,Liu X Y,Liu X M,et al.Calf spleen extract alleviates cyclophosphamide-induced leucopenia in mice and inhibits the glycolysis of HL60cells[J].J Chin Pharm Sci,2011,20(2):181-187.
[14]孟玮,史晓宇,张敬,等.小牛脾提取物联合奥沙利铂方案治疗晚期结肠癌的临床观察[J].中国煤炭工业医学杂志,2017,20(7):828-831.
[15]赵敏,张辉,周颖,等.胃癌血清应答因子和血管内皮生长因子受体2的表达及其临床意义[J].肿瘤研究与临床,2016,28(2):112-115.
[16]刘兆君.SRF等胃癌转移相关基因CpG岛甲基化标志物筛选和验证[A].中国抗癌协会肿瘤流行病学专业委员会.全国肿瘤流行病学和肿瘤病因学学术会议论文集[C].承德:中华医学会中华预防医学杂志社,2011:126.
[17]Wang W A,Groenendyk J,Michalak M.Endoplasmic reticulum stress associated responses in cancer[J].Biochim Biophys Acta,2014,1843(10):2143-2149.
[18]高雁艳.氧调节蛋白(ORP150)在蛋白酶体抑制剂诱导甲状腺癌细胞凋亡中的作用[D].沈阳:中国医科大学,2012.
[19]彭浩,杨华伟,宋立伟,等.胃癌患者血清ORP150水平及其临床意义[J].医学研究杂志,2016,45(6):67-69.
[20]魏华.氧化应激诱导间充质干细胞凋亡及磷脂类分子调节血管内皮生长因子分泌研究[D].北京:中国协和医科大学,2010.
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