Traditional Chinese Medicine Syndromes Distribution in Colorectal Cancer and its Association with Western Medicine Treatment and Clinical Laboratory Indicators
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摘要
Objective:The objective of the study is to explore the traditional Chinese medicine(TCM)syndrome distribution in colorectal cancer(CRC)and its correlation with treatment methods and clinical laboratory indicators.Materials and Methods:Using the CRC cases report form of TCM,760 CRC patients with TCM four diagnosis information,western medicine treatment information and clinical laboratory indicators were collected,and TCM syndromes distribution in CRC were summarized.The correlation between TCM syndrome type and western medicine treatments,clinical laboratory indicators such as liver and kidney function,immune function,and tumor biomarkers was analyzed.Results:In760 cases of CRC,Spleen deficiency syndrome(SDS,25%),liver and kidney Yin deficiency syndrome(LKYDS,13%) , LKYDS-SDS,12%,spleen deficient Qi stagnation syndrome(SDQSS,10%),and damp heat syndrome(DHS,9%)were more common TCM syndrome types.LKYDS,SDS,LKYDS-SDS,and SDQSS were significantly distributed under different treatment methods(P<0.001).There was no statistically significant difference in the distribution of immune function and cytokine among the five TCM syndromes(P>0.05),but there was statistically significant difference in the distribution of blood routine,liver and kidney function,and tumor biomarkers(P<0.05).Conclusion:LKYDS,SDS,LKYDS-SDS,SDQSS,and DHS were the first five TCM syndromes in CRC.There were the significant correlations between the distribution of TCM syndrome and the clinical laboratory indicators,and the distribution of TCM syndromes was affected by surgery,radiotherapy,and chemotherapy.
Objective:The objective of the study is to explore the traditional Chinese medicine(TCM)syndrome distribution in colorectal cancer(CRC)and its correlation with treatment methods and clinical laboratory indicators.Materials and Methods:Using the CRC cases report form of TCM,760 CRC patients with TCM four diagnosis information,western medicine treatment information and clinical laboratory indicators were collected,and TCM syndromes distribution in CRC were summarized.The correlation between TCM syndrome type and western medicine treatments,clinical laboratory indicators such as liver and kidney function,immune function,and tumor biomarkers was analyzed. Results:In760 cases of CRC,Spleen deficiency syndrome(SDS,25%),liver and kidney Yin deficiency syndrome(LKYDS,13%), LKYDS-SDS,12%,spleen deficient Qi stagnation syndrome(SDQSS,10%),and damp heat syndrome(DHS,9%)were more common TCM syndrome types.LKYDS,SDS,LKYDS-SDS,and SDQSS were significantly distributed under different treatment methods(P<0.001).There was no statistically significant difference in the distribution of immune function and cytokine among the five TCM syndromes(P>0.05),but there was statistically significant difference in the distribution of blood routine,liver and kidney function,and tumor biomarkers(P<0.05).Conclusion:LKYDS,SDS,LKYDS-SDS,SDQSS,and DHS were the first five TCM syndromes in CRC.There were the significant correlations between the distribution of TCM syndrome and the clinical laboratory indicators,and the distribution of TCM syndromes was affected by surgery,radiotherapy,and chemotherapy.
Objective:The objective of the study is to explore the traditional Chinese medicine(TCM)syndrome distribution in colorectal cancer(CRC)and its correlation with treatment methods and clinical laboratory indicators.Materials and Methods:Using the CRC cases report form of TCM,760 CRC patients with TCM four diagnosis information,western medicine treatment information and clinical laboratory indicators were collected,and TCM syndromes distribution in CRC were summarized.The correlation between TCM syndrome type and western medicine treatments,clinical laboratory indicators such as liver and kidney function,immune function,and tumor biomarkers was analyzed. Results:In760 cases of CRC,Spleen deficiency syndrome(SDS,25%),liver and kidney Yin deficiency syndrome(LKYDS,13%), LKYDS-SDS,12%,spleen deficient Qi stagnation syndrome(SDQSS,10%),and damp heat syndrome(DHS,9%)were more common TCM syndrome types.LKYDS,SDS,LKYDS-SDS,and SDQSS were significantly distributed under different treatment methods(P<0.001).There was no statistically significant difference in the distribution of immune function and cytokine among the five TCM syndromes(P>0.05),but there was statistically significant difference in the distribution of blood routine,liver and kidney function,and tumor biomarkers(P<0.05).Conclusion:LKYDS,SDS,LKYDS-SDS,SDQSS,and DHS were the first five TCM syndromes in CRC.There were the significant correlations between the distribution of TCM syndrome and the clinical laboratory indicators,and the distribution of TCM syndromes was affected by surgery,radiotherapy,and chemotherapy.
引文
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10.Wang HB,Sun Y,Cao Z,Wu LF,Ding CH.Study on the standardization of TCM syndromes of hypertension.China J Traditional Chin Med Pharm 2018;33:603-5.
11.Yang MD,Chen XL,Zhu MD,Wang WH,Luo YQ,Su SB.Advanced in Zheng research in digestive system malignant tumor.Traditional Chin Med 2017;6:110-7.
12.Ministry of Health of the People’s Republic of China.Guidelines for Clinical Research on New Chinese Medicine.Series 3;1997.
13.Department of Health,Ministry of Health.Guidelines for diagnosis and treatment of colorectal cancer(2010 Edition).China Contin Med Educ2011;49:97-104.
14.Oken MM,Creech RH,Tormey DC,Horton J,Davis TE,McFadden ET,et al.Toxicity and response criteria of the eastern cooperative oncology group.Am J Clin Oncol 1982;5:649-55.
15.Xie TY,Cao JZ,Zhao ST,Wen CB.Research of new algorithms based on big data deep learning for TCM syndrome to prescription.Asia Pac Traditional Med 2018;14:51-3.
16.Guan MH,Li XX.Comparison of different minimally invasive solutions efficacy for patients with liver cancer.Pract J Cancer 2015;30:603-5.
17.Guo Y,Zou Y,Xu YF,Wang H,Li Y,Qian LY,et al.Study on chinese medicine syndrome of colorectal carcinoma in perioperative period.Chin J Integr Med 2015;21:183-7.
18.Jia DP,Li B.Research on the variety of traditional Chinese medicine syndromes for gastrointestinal cancer patients after surgery.J Liaoning Univ Traditional Chin Med 2016;18:214-7.
19.Zhang WH,Lin SY,Wang XX.Analysis of the influence of tumor chemotherapy on TCM syndromes of colorectal cancer-Retrospective study of 511 syndromes of colorectal cancer.Zhejiang J Integrated Traditional Chin Western Med 2014;24:278-9.
20.Wei YB.Retrospective study on TCM syndromes and related factors of 334 cases of colorectal cancer.Guangxi Univ Traditional Chin Med2016.
21.Qiu YY,Liang B,Hu SJ,Bao YJ,Shi XJ,Yu H,et al.Modern literature research on the distribution characteristics of TCM syndromes in colorectal cancer.Acad J Shanghai Univ Traditional Chin Med 2014;28:52-5.
22.Rong JY.Clinical Study on Traditional Chinese Medicine Syndromes and its Influencing Factors in Colorectal Cancer.Guangzhou:Guangzhou University of Traditional Chinese Medicine;2009.
23.Yang JB,Zhang J,Ma CZ.The clinical efficacy of Jianpifuzheng decoction and effect on immune function and quality of life in patients with terminal primary hepatoma.Pharmacol Clin Chin Materia Med 2017;33:163-6.
24.Jiang Q,Huo JG,Wang XN.Research progress on colorectal cancer syndrome distribution characteristics and biological basis.China Med Herald 2015;12:28-30.
25.Chen J,Li XY,Cai FF,Hu XQ,Lu YY,Su SB.Analysis on‘same disease but different syndromes’and‘same syndrome exist in different disease’of post-operation of liver cancer and colorectal cancer based on multiplex biometric immunoassay technology.China J Traditional Chin Med Pharm 2017;32:2098-103.
26.Su SB.Recent advances in ZHENG differentiation research in traditional Chinese medicine.Int J Integr Med 2013;1:1-10.
27.Dai J,Fang J,Sun S,Chen Q,Cao H,Zheng N,et al.ZHENG-omics application in ZHENG classification and treatment:Chinese personalized medicine.Evid Based Complement Alternat Med 2013;2013:235969.
28.Chen J,Chen QL,Su SB.Thoughts and exploration of traditional Chinese precision medical treatment.Modernization Traditional Chin Med Materia Med World Sci Technol 2016;18:557-62.
2.Zhang YF.Observation of the efficacy and adverse effects of laparoscopic surgery for colon cancer.China J Pharm Econ 2018;13:56-9.
3.Hu P,Feng G,Gao JF.Therapeutic effect and adverse reactions of FOLFOX and XELOX adjuvant chemotherapy regimens on colon cancer with stage II/III.Chin J Clin Res 2016;29:1544-6.
4.Zhu TF,Li CG.The clinical study of different preoperative radiotherapy pattern treated to rectum cancer.Chin J Surg Oncol 2018;10:120-2.
5.Feng YY,Zhou LH,Li Q.Research status and progress of strengthening spleen therapy in treatment of colorectal cancer.China J Traditional Chin Med Pharm 2015;30:4013-5.
6.Huang XW,Shen KP,Hu B.Effects and mechanism of Chinese herbs against multidrug resistance in colorectal carcinoma.Chin Arch Traditional Chin Med 2018;36:894-7.
7.Chen J,Yang Z,Tang DX,Luo L,Wang JH,Wang Q,et al.A review on the significance of traditional Chinese medicine in prevention and treatment of colorectal cancer with liver metastasis.Jiangxi J Traditional Chin Med 2018;49:7-9.
8.Yang B,Yang Z,Tang DX,Long FX,Luo L,Li J,et al.Prevention and treatment of traditional Chinese medicine in colorectal cancer.Modern JIntegrated Traditional Chin Western Med 2016;25:2389-92.
9.Hu XQ,Chen J,Chen QL,Lu YY,Su SB.Genome-wide methylation analysis in the same syndrome between the chronic hepatitis B and hepatitis B-related cirrhosis.Modernization Traditional Chin Med Materia Med World Sci Technol 2016;18:1452-9.
10.Wang HB,Sun Y,Cao Z,Wu LF,Ding CH.Study on the standardization of TCM syndromes of hypertension.China J Traditional Chin Med Pharm 2018;33:603-5.
11.Yang MD,Chen XL,Zhu MD,Wang WH,Luo YQ,Su SB.Advanced in Zheng research in digestive system malignant tumor.Traditional Chin Med 2017;6:110-7.
12.Ministry of Health of the People’s Republic of China.Guidelines for Clinical Research on New Chinese Medicine.Series 3;1997.
13.Department of Health,Ministry of Health.Guidelines for diagnosis and treatment of colorectal cancer(2010 Edition).China Contin Med Educ2011;49:97-104.
14.Oken MM,Creech RH,Tormey DC,Horton J,Davis TE,McFadden ET,et al.Toxicity and response criteria of the eastern cooperative oncology group.Am J Clin Oncol 1982;5:649-55.
15.Xie TY,Cao JZ,Zhao ST,Wen CB.Research of new algorithms based on big data deep learning for TCM syndrome to prescription.Asia Pac Traditional Med 2018;14:51-3.
16.Guan MH,Li XX.Comparison of different minimally invasive solutions efficacy for patients with liver cancer.Pract J Cancer 2015;30:603-5.
17.Guo Y,Zou Y,Xu YF,Wang H,Li Y,Qian LY,et al.Study on chinese medicine syndrome of colorectal carcinoma in perioperative period.Chin J Integr Med 2015;21:183-7.
18.Jia DP,Li B.Research on the variety of traditional Chinese medicine syndromes for gastrointestinal cancer patients after surgery.J Liaoning Univ Traditional Chin Med 2016;18:214-7.
19.Zhang WH,Lin SY,Wang XX.Analysis of the influence of tumor chemotherapy on TCM syndromes of colorectal cancer-Retrospective study of 511 syndromes of colorectal cancer.Zhejiang J Integrated Traditional Chin Western Med 2014;24:278-9.
20.Wei YB.Retrospective study on TCM syndromes and related factors of 334 cases of colorectal cancer.Guangxi Univ Traditional Chin Med2016.
21.Qiu YY,Liang B,Hu SJ,Bao YJ,Shi XJ,Yu H,et al.Modern literature research on the distribution characteristics of TCM syndromes in colorectal cancer.Acad J Shanghai Univ Traditional Chin Med 2014;28:52-5.
22.Rong JY.Clinical Study on Traditional Chinese Medicine Syndromes and its Influencing Factors in Colorectal Cancer.Guangzhou:Guangzhou University of Traditional Chinese Medicine;2009.
23.Yang JB,Zhang J,Ma CZ.The clinical efficacy of Jianpifuzheng decoction and effect on immune function and quality of life in patients with terminal primary hepatoma.Pharmacol Clin Chin Materia Med 2017;33:163-6.
24.Jiang Q,Huo JG,Wang XN.Research progress on colorectal cancer syndrome distribution characteristics and biological basis.China Med Herald 2015;12:28-30.
25.Chen J,Li XY,Cai FF,Hu XQ,Lu YY,Su SB.Analysis on‘same disease but different syndromes’and‘same syndrome exist in different disease’of post-operation of liver cancer and colorectal cancer based on multiplex biometric immunoassay technology.China J Traditional Chin Med Pharm 2017;32:2098-103.
26.Su SB.Recent advances in ZHENG differentiation research in traditional Chinese medicine.Int J Integr Med 2013;1:1-10.
27.Dai J,Fang J,Sun S,Chen Q,Cao H,Zheng N,et al.ZHENG-omics application in ZHENG classification and treatment:Chinese personalized medicine.Evid Based Complement Alternat Med 2013;2013:235969.
28.Chen J,Chen QL,Su SB.Thoughts and exploration of traditional Chinese precision medical treatment.Modernization Traditional Chin Med Materia Med World Sci Technol 2016;18:557-62.
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