SPECT双探头前、后位显像分别测量腮腺功能的比较研究
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摘要
目的:探讨在SPECT唾液腺显像中分别进行前、后位图像采集获得腮腺功能参数的差异。方法:对64例患者应用SPECT进行对向双探头前、后位~(99)Tc~mO_4~-唾液腺动态显像(SGS)。勾画腮腺ROI,获得腮腺净计数(Count_(net)),并计算前、后位腮腺15 min摄取率(UR_(15))及酸刺激后排泌分数(EF),使用Wilcoxon秩和检验分别比较前后位15 min腮腺净计数(Count_(net15))、酸刺激前最大净计数值(Count_(max))、腮腺UR_(15)及EF。结果:前、后位图像中,左腮腺Count_(net15)分别为2.46±1.29、2.92±1.70(Z=-3.42,P=0.01),右侧分别为2.82±1.55、3.06±1.76(Z=-2.25,P=0.03);左侧腮腺酸刺激前Count_(max)分别为2.79±1.50、3.23±1.87(Z=-3.09,P<0.01),右侧分别为3.20±1.69、3.48±1.92(Z=-2.17,P=0.03)。前、后位图像中左侧UR_(15)分别为(1.71±0.76)%、(2.74±1.38)%(Z=-6.34,P<0.01),右侧分别为(1.97±1.01)%、(2.86±1.45)%(Z=-6.11,P<0.01);左侧EF分别为(74.84±14.81)%、(76.61±15.91)%(Z=-3.92,P<0.01),右侧分别为(71.17±15.34)%、(71.48±14.90)%(Z=-4.68,P<0.01)。双侧腮腺后位Count_(net15)、酸刺激前Count_(max)均高于前位,且差异有统计学意义;双侧腮腺前位UR_(15)均高于后位,且差异有统计学意义;双侧腮腺后位EF均低于前位且差异有统计学意义。结论:前、后位采集腮腺动态显像所获得的摄取及排泌参数均有差异,差异是下颌支的骨性衰减所导致。
Objective: To investigate the difference of the functional parameters of the parotid glands obtained by the anterior and posterior scanning in SPECT salivary glands scintigraphy(SGS). Methods: Sixty-four patients underwent SGS, which was performed by dual-detector SPECT with ~(99)Tc~mO_4~-. The parotid ROI was delineated to obtain the net counts of parotid glands(Count_(net)). The 15 min uptake ratio(UR_(15)) of the parotid gland, and the excretion fraction(EF) after acid stimulation at the anterior and posterior imaging were calculated. The Wilcoxon rank-sum test was used to compare the difference in the 15 min net counts(Count_(net15)), the maximum net count before acid stimulation(Count_(max)) of the parotid glands, the UR_(15) and EF of the anterior and posterior scanning, respectively. Results: In the anterior and posterior images, the Count_(net15) of the left parotid gland were 2.46±1.29 vs. 2.92±1.70(Z=-3.42, P=0.01), and the right ones were 2.82±1.55 vs. 3.06±1.76, respectively(Z=-2.25,P=0.03). The Count_(max)of left parotid gland were 2.79±1.50 vs. 3.23±1.87(Z=-3.09, P<0.01), and the right ones were 3.20±1.69 vs. 3.48±1.92(Z=-2.17, P=0.03). The UR_(15) of the left parotid at the anterior and posterior images were(1.71 ±0.76)% vs.(2.74 ±1.38)%(Z =-6.34, P <0.01), and the right were(1.97 ±1.01)% vs.(2.86 ±1.45)%(Z =-6.11, P <0.01). The EF of the left parotid were(74.84±14.81)% vs.(76.61 ±15.91)%(Z =-3.92, P <0.01), and the right were(71.17 ±15.34)% vs.(71.48 ±14.90)%(Z=-4.68, P<0.01). The Count_(net15) and Count_(max)of both parotid glands in the posterior images were significantly higher than the anterior ones. The anterior UR_(15) of both parotid glands were significantly higher than that in the posterior ones. The EF of both parotids in the posterior images were significantly lower than that in the anterior. Conclusion: There are differences in the uptake and excretion of parotid glands dynamic imaging between the anterior and posterior scanning. The difference is caused by the osseous attenuation of the mandibular branch.
Objective: To investigate the difference of the functional parameters of the parotid glands obtained by the anterior and posterior scanning in SPECT salivary glands scintigraphy(SGS). Methods: Sixty-four patients underwent SGS, which was performed by dual-detector SPECT with ~(99)Tc~mO_4~-. The parotid ROI was delineated to obtain the net counts of parotid glands(Count_(net)). The 15 min uptake ratio(UR_(15)) of the parotid gland, and the excretion fraction(EF) after acid stimulation at the anterior and posterior imaging were calculated. The Wilcoxon rank-sum test was used to compare the difference in the 15 min net counts(Count_(net15)), the maximum net count before acid stimulation(Count_(max)) of the parotid glands, the UR_(15) and EF of the anterior and posterior scanning, respectively. Results: In the anterior and posterior images, the Count_(net15) of the left parotid gland were 2.46±1.29 vs. 2.92±1.70(Z=-3.42, P=0.01), and the right ones were 2.82±1.55 vs. 3.06±1.76, respectively(Z=-2.25,P=0.03). The Count_(max)of left parotid gland were 2.79±1.50 vs. 3.23±1.87(Z=-3.09, P<0.01), and the right ones were 3.20±1.69 vs. 3.48±1.92(Z=-2.17, P=0.03). The UR_(15) of the left parotid at the anterior and posterior images were(1.71 ±0.76)% vs.(2.74 ±1.38)%(Z =-6.34, P <0.01), and the right were(1.97 ±1.01)% vs.(2.86 ±1.45)%(Z =-6.11, P <0.01). The EF of the left parotid were(74.84±14.81)% vs.(76.61 ±15.91)%(Z =-3.92, P <0.01), and the right were(71.17 ±15.34)% vs.(71.48 ±14.90)%(Z=-4.68, P<0.01). The Count_(net15) and Count_(max)of both parotid glands in the posterior images were significantly higher than the anterior ones. The anterior UR_(15) of both parotid glands were significantly higher than that in the posterior ones. The EF of both parotids in the posterior images were significantly lower than that in the anterior. Conclusion: There are differences in the uptake and excretion of parotid glands dynamic imaging between the anterior and posterior scanning. The difference is caused by the osseous attenuation of the mandibular branch.
引文
[1]李亚明.核医学教程[M].北京:科学出版社,2014:155-157.
[2]潘中允.实用核医学[M].北京:人民卫生出版社,2014:419-426.
[3]张晓辉,彭祖光,李永明,等.99m TcO4-显像与MRI和CT对比评价腮腺Warthin’s瘤的诊断价值[J].中国医学物理学杂志,2017,34(6):603-606.
[4]许永照,李楠.国人腮腺形态及其导管的解剖学研究[J].首都医科大学学报,1994,15(3):165-171.
[5]李龙江,赵洪伟.腮腺区应用解剖特点与术式改良[J].中国实用口腔科杂志,2008,1(3):138-141.
[6]郭雷鸣,陈涛,孙晓光,等.双探头SPECT对向平面显像放射性活度定量的模型研究[J].核技术,2005,28(11):859-862.
[7]Wu JQ,Feng HJ,Ouyang W,et al.Systematic evaluation of salivary gland damage following I-131 therapy in differentiated thyroid cancer patients by quantitative scintigraphy and clinical follow-up[J].Nucl Med Commun,2015,36(8):819.
[8]杨亲亲,刘志翔.唾液腺动态显像对口干患者腮腺摄取功能损伤程度的研究[J].中国临床医学影像杂志,2016,27(5):328-332.
[9]邹惠峰,沈阳,尤嘉熙,等.唾液腺显像诊断干燥综合征[J].中国医学影像技术,2017,33(3):399-403.
[10]杜世文,俞创奇.锥形束CT腮腺造影技术对腮腺非肿瘤性疾病的诊断价值[J].中国口腔颌面外科杂志,2017,15(4):345-348.
[11]陈炬辉,吴海山,郑步宏,等.鼻咽癌调强放疗根据CT和MRI勾画腮腺的比较研究[J].中国癌症防治杂志,2009,1(2):130-133.
[12]Sakoshi M,Matsutomo N,Yamamoto T,et al.Effect of Misregistration between SPECT and CT Images on Attenuation Correction for Quantitative Bone SPECT Imaging[J].Nihon Hoshasen Gijiutsu Gakkai Zasshi,2018,74(5):452-458.
[13]Barker JL Jr,Garden AS,Ang KK,et al.Quantification of volumetric and geometric changes occurring during fractionated radiotherapy for head-and-neck cancer using an integrated CT/linear accelerator system[J].Int J Radiat Oncol Biol Phys,2004,59(4):960-970.
[14]Broggi S,Fiorino C,Dell’Oca I,et al.A two-variable linear model of parotid shrinkage during IMRT for head and neck cancer[J].Radiother Oncol,2010,94(2):206-212.
[15]Wang W,Yang H,Hu W,et al.Clinical Study of the Necessity of Replanning Before the 25th Fraction During the Course of Intensity-Modulated Radiotherapy for Patients With Nasopharyngeal Carcinoma[J].Int J Radiat Oncol Biol Phys,2010,77(2):617-621.
[16]Jentzen W,Balschuweit D,Schmitz J,et al.The influence of saliva flow stimulation on the absorbed radiation dose to the salivary glands during radioiodine therapy of thyroid cancer using 124I PET(/CT)imaging[J].Eur J Nucl Med Mol Imaging,2010,37(12):2298-2306.
[17]Goshen E,Beilin L,Stern E,et al.Feasibility study of a novel general purpose CZT-based digital SPECT camera:initial clinical results[J].EJNMI Phys,2018,5(1):6.
[2]潘中允.实用核医学[M].北京:人民卫生出版社,2014:419-426.
[3]张晓辉,彭祖光,李永明,等.99m TcO4-显像与MRI和CT对比评价腮腺Warthin’s瘤的诊断价值[J].中国医学物理学杂志,2017,34(6):603-606.
[4]许永照,李楠.国人腮腺形态及其导管的解剖学研究[J].首都医科大学学报,1994,15(3):165-171.
[5]李龙江,赵洪伟.腮腺区应用解剖特点与术式改良[J].中国实用口腔科杂志,2008,1(3):138-141.
[6]郭雷鸣,陈涛,孙晓光,等.双探头SPECT对向平面显像放射性活度定量的模型研究[J].核技术,2005,28(11):859-862.
[7]Wu JQ,Feng HJ,Ouyang W,et al.Systematic evaluation of salivary gland damage following I-131 therapy in differentiated thyroid cancer patients by quantitative scintigraphy and clinical follow-up[J].Nucl Med Commun,2015,36(8):819.
[8]杨亲亲,刘志翔.唾液腺动态显像对口干患者腮腺摄取功能损伤程度的研究[J].中国临床医学影像杂志,2016,27(5):328-332.
[9]邹惠峰,沈阳,尤嘉熙,等.唾液腺显像诊断干燥综合征[J].中国医学影像技术,2017,33(3):399-403.
[10]杜世文,俞创奇.锥形束CT腮腺造影技术对腮腺非肿瘤性疾病的诊断价值[J].中国口腔颌面外科杂志,2017,15(4):345-348.
[11]陈炬辉,吴海山,郑步宏,等.鼻咽癌调强放疗根据CT和MRI勾画腮腺的比较研究[J].中国癌症防治杂志,2009,1(2):130-133.
[12]Sakoshi M,Matsutomo N,Yamamoto T,et al.Effect of Misregistration between SPECT and CT Images on Attenuation Correction for Quantitative Bone SPECT Imaging[J].Nihon Hoshasen Gijiutsu Gakkai Zasshi,2018,74(5):452-458.
[13]Barker JL Jr,Garden AS,Ang KK,et al.Quantification of volumetric and geometric changes occurring during fractionated radiotherapy for head-and-neck cancer using an integrated CT/linear accelerator system[J].Int J Radiat Oncol Biol Phys,2004,59(4):960-970.
[14]Broggi S,Fiorino C,Dell’Oca I,et al.A two-variable linear model of parotid shrinkage during IMRT for head and neck cancer[J].Radiother Oncol,2010,94(2):206-212.
[15]Wang W,Yang H,Hu W,et al.Clinical Study of the Necessity of Replanning Before the 25th Fraction During the Course of Intensity-Modulated Radiotherapy for Patients With Nasopharyngeal Carcinoma[J].Int J Radiat Oncol Biol Phys,2010,77(2):617-621.
[16]Jentzen W,Balschuweit D,Schmitz J,et al.The influence of saliva flow stimulation on the absorbed radiation dose to the salivary glands during radioiodine therapy of thyroid cancer using 124I PET(/CT)imaging[J].Eur J Nucl Med Mol Imaging,2010,37(12):2298-2306.
[17]Goshen E,Beilin L,Stern E,et al.Feasibility study of a novel general purpose CZT-based digital SPECT camera:initial clinical results[J].EJNMI Phys,2018,5(1):6.
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