丹红注射液辅助前列地尔治疗高龄糖尿病肾病患者的临床效果研究

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英文篇名：Clinical Effect of Danhong Injection Assisted with Alprostadil in Treatment of Elderly Patients with Diabetic Nephropathy 作者：林称心 ; 李光智 ; 方团育 英文作者：LIN Chenxin;LI Guangzhi;FANG Tuanyu;Department of Endocrinology, Hainan Provincial Hospital of Traditional Chinese Medicine;Department of Cardiac Diseases, Hainan Provincial Hospital of Traditional Chinese Medicine;Department of Endocrinology, Hainan Provincial People's Hospital; 关键词：丹红注射液 ; 前列地尔 ; 高龄 ; 糖尿病肾病 ; 肾功能 英文关键词：Danhong Injection;;alprostadil;;advanced age;;diabetic nephropathy;;renal function 中文刊名：ZYHS 英文刊名：Chinese Archives of Traditional Chinese Medicine 机构：海南省中医院内分泌科;海南省中医院心病科;海南省人民医院内分泌科; 出版日期：2019-06-10 出版单位：中华中医药学刊 年：2019 期：v.37 基金：海南省卫生厅重点科研项目(琼卫2010重点-32) 语种：中文; 页：ZYHS201906053 页数：3 CN：06 ISSN：21-1546/R 分类号：213-215

摘要

目的:分析丹红注射液辅助前列地尔治疗高龄糖尿病肾病患者的临床效果。方法:选取高龄糖尿病肾病患者64例,随机分为两组。其中32例采用常规治疗+前列地尔(对照组),其余32例采用常规治疗+前列地尔+丹红注射液(观察组),分析两组患者治疗后的临床效果。结果:观察组患者总有效率(84.38%)高于对照组(59.38%)(P<0.05)。治疗前,两组患者血糖指标、肾功能指标、PAC-1、TNF-α、8-OHdG、T-AOC水平比较,差异无统计学意义(P>0.05)。治疗后,观察组患者FPG、2 hPG、肾功能指标、PAC-1、TNF-α、8-OHdG水平低于对照组,T-AOC水平高于对照组(P<0.05)。结论:丹红注射液辅助前列地尔治疗高龄糖尿病肾病可降低患者血糖,改善患者肾功能,减轻机体氧化应激反应。
        Objective:To study the clinical effect of Danhong Injection in the treatment of senile diabetic nephropathy patients with alprostadil. Methods:64 elderly patients with diabetic nephropathy were randomly divided into two groups. Thirty-two cases were treated with alprostadil(control group) and the other 32 cases were treated with Danhong Injection(observation group). Results:The total effective rate in the observation group(84.38%) was higher than that in the control group(59.38%)(P<0.05). Before treatment, there was no significant difference in blood glucose and renal function between the two groups(P>0.05). After treatment, the levels of PG2 and PAC-1 TNF-α 8-OHdG in the observation group were lower than those in the control group(P<0.05). Conclusion:Danhong Injection combined with alprostadil in the treatment of senile diabetic nephropathy can reduce blood sugar, improve renal function and alleviate oxidative stress.

引文

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