甲氧基丙烯酸酯类杀菌剂苯醚菌酯及其开发
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摘要
新型甲氧基丙烯酸酯类杀菌剂苯醚菌酯具有与啶氧菌酯相同的作用机理和类似的化学结构,具有杀菌谱广、多重活性作用方式,对多种植物病害性均有较好防效。特别地,苯醚菌酯可共用啶氧菌酯的中间体进行生产,因而生产和用药成本更低,具有一定的市场开发潜力。苯醚菌酯的理化性质与毒性、代谢与残留、作用机理与活性抗性、原药生产与供应、制剂开发和应用等方面值得关注。
Bemystrobin, a novel strobilurin fungicide, owns same mode of action and similar chemical structure as Picoxystrobin. It features with broad fungicidal spectrum, multiple actions and excellent control effects against various plant pathogenic fungi. In particular, Bemystrobin can share a key intermediate of Picoxystrobin for lower cost of production and application, which benefits its marketing potential. The physicochemical properties and toxicity, metabolism and residue, mode of action, activity and resistance, technical production and supply, formulation development and application of Bemystrobin are worthy of attention.
Bemystrobin, a novel strobilurin fungicide, owns same mode of action and similar chemical structure as Picoxystrobin. It features with broad fungicidal spectrum, multiple actions and excellent control effects against various plant pathogenic fungi. In particular, Bemystrobin can share a key intermediate of Picoxystrobin for lower cost of production and application, which benefits its marketing potential. The physicochemical properties and toxicity, metabolism and residue, mode of action, activity and resistance, technical production and supply, formulation development and application of Bemystrobin are worthy of attention.
引文
[1]许天明,陈定花,孔小林,等.甲氧基丙烯酸甲酯类化合物杀菌剂:CN,1456054A[P].2003-11-19.
[2]许天明.新型高效杀菌剂---苯醚菌酯[J].世界农药,2006,(6):51-52.
[3]徐浩,李振,赵华,等.新农药苯醚菌酯(ZJ0712)在黄瓜及土壤中的残留研究[J].农业环境科学学报,2006(b09):595-598.
[4]Wang L K,Zhao J H,Laura D M,et al.Degradation and metabolic profiling for benzene kresoxim-methyl using carbon-14 tracing[J].Science of The Total Environment,2018,637-638:1221-1229.
[5]Zhao J H,Wang L K,Cheng J L,et al.Fate characterization of benzene kresoxim-methyl(a strobilurin fungicide)in different aerobic soils[J].Journal of Environment Quality,2017,46(3):546-552.
[6]BCPC(British Crop Production Council).e-Pesticide Manual version 6.0[DB/CD].Hampshire:BCPC(British Crop Production Council),2012-11.
[7]Fungicide Resistance Action Committee(FRAC).SDHIfungicides>Introduction and General Information[EM/OL].[2019-01-28].http://www.frac.info/working-group/sdhi-fungicides/introduction-and-general-information.
[8]Dave W B,John M C,Jeremy R G,et al.The strobilurin fungicides[J].Pest Management Science,2002,7(7):649-662.
[9]陈定花,朱卫刚,胡伟群,等.新型广谱杀菌剂苯醚菌酯(ZJ0712)生物活性[J].农药,2006,45(1):18-21.
[10]王海强,周俞辛,王景元,等.水稻稻瘟病菌不同发育阶段对7种QoI类杀菌剂的敏感性[J].农药学学报,2009,11(4):434-440.
[11]周俞辛,杨云碧,张彧,等.荔枝霜疫霉不同发育阶段对4种QoI类杀菌剂的敏感性[J].农药学学报,2016,18(1):57-64.
[12]陈定花,朱卫刚,胡伟群,等.新型广谱杀菌剂苯醚菌酯(ZJ0712)生物活性[J].农药,2006,45(1):18-21.
[13]侯欣,陈国庆,王兴红,等.3种柑橘病原真菌对苯醚菌酯和苯醚甲环唑敏感基线研究[J].浙江大学学报(农业与生命科学版),2013,39(1):62-68.
[14]朱卫刚,胡伟群,张蕊蕊,等.5种新型杀菌剂对草莓白粉病的生物活性研究[J].中国南方果树,2014,43(3):114-115.
[15]金丽华,陈长军,王建新,等.嘧菌酯及SHAM对4种植物病原真菌的活性和作用方式研究[J].中国农业科学,2007,(10):2206-2213.
[16]王敏,韩平,卢晓红,等.黄瓜白粉病菌对苯醚菌酯敏感基线的建立及室内抗药性风险评价[J].植物病理学报,2007,37(6):660-665.
[17]胡伟群,陈定花,朱卫刚,等.抗苯醚菌酯(ZJ0712)小麦白粉病菌突变体的诱导及其生物学特性[J].农药学学报,2009,11(2):203-207.
[18]杜飞,缪钱江,梅馨月,等.葡萄霜霉病菌对主要杀菌剂的抗性监测[C].中国植物病理学会学术年会,2015.
[19]Zhou Y X,Chen L,Hu J,et al.Resistance mechanisms and molecular docking studies of four novel QoI fungicides in peronophythora litchi[J].Scientific Reports,2015,5:17466.
[20]Zhou Y X,Chen L,Hu J,et al.Baseline sensitivity of natural population and resistance risk ofPeronophythora litchiito four novel QoI fungicides[J].European Journal of Plant Pathology,2016,146(1):71-83.
[21]胡伟群,朱卫刚,张蕊蕊,等.灰葡萄孢多药抗性菌株的筛选和鉴定[J].农药学学报,2011,13(6):586-590.
[22]沈剑仕,曹根法,张新忠,等.苯醚菌酯的合成方法[J].农药,2014,53(10):718-719.
[23]韩萍,郑舟,周坤英,等.苯醚菌酯(ZJ0712)的高效液相色谱分析[J].农药,2012,51(2):117-118.
[24]陈定花,胡伟群,朱卫刚,等.新型广谱杀菌剂10%苯醚菌酯SC(ZJ0712)应用技术[J].农药,2006,45(3):162-164.
[25]李进京,叶春雷,谢志军.5种药剂对胡麻白粉病的防效[J].甘肃农业科技,2015,(9):46-48.
[26]徐暄,孙其文,王永强.几种新型药剂对西瓜白粉病的防治效果研究[J].安徽农学通报,2015,(15):83-84.
[27]王萍莉.10%苯醚菌酯悬浮剂对籽用西瓜白粉病的药效研究[J].北方园艺,2012,(22):131-132.
[28]尤爱琴,张昌杰,胡宇峰,等.5种杀菌剂对小麦赤霉病的防治效果初探[J].浙江农业科学,2012,1(4):532-535.
[29]王志鹏,王建玉,段祥坤.不同药剂对甜瓜白粉病的防效研究[J].新疆农垦科技,2017,40(7):34-35.
[30]韩盛,杨渡,李承业,等.打瓜白粉病药剂防治技术研究[J].新疆农业科学,2012,49(1):101-104.
[31]胡凤云,蒋妮,叶云峰,等.积雪草漆斑病病原鉴定及室内药剂筛选[J].广西植物,2016,36(8):993-999.
[32]徐桂方,陈二龙,姜国庆,等.早稻稻瘟病田间药效试验[J].植物医生,2015(4):32-33.
[33]陈二龙,刘惠英,甘琴,等.7种药剂防治中稻稻瘟病试验[J].植物医生,2016,29(11):52-54.
[34]涂勇.雪莲果镰刀叶斑病病原菌鉴定及杀菌剂室内毒力测定[J].江苏农业科学,2014,42(12):179-181.
[35]高海峰,王锁牢,努尔孜亚·亚力买买提,等.果麦间作模式下小麦叶锈病田间消长规律及药剂防治试验[J].新疆农业科学,2015,52(3):487-492.
[36]许勇华,胡冬松,高云英,等.3种有机硅助剂对2种水性化农药制剂的增效作用[J].现代农药,2011,10(3):20-23.
[37]严凯,费礼婵,杨泽宏.葡萄霜霉病的田间调查及防治效果研究[J].农业研究与应用,2015,156(1):36-38.
[38]金向红,张登科,黄松其,等.50%苯醚菌酯干悬浮剂配方研制[J].农药,2014,(1):23-25.
[39]陈定花,朱卫刚,胡伟群,等.苯醚菌酯?戊唑醇防治白粉病生物活性[J].农药,2009,48(7):527-528.
[40]朱卫刚,陈定花,胡伟群,等.苯醚菌酯·霜霉威防治黄瓜霜霉病生物活性[J].农药,2009,48(9):694-695.
[2]许天明.新型高效杀菌剂---苯醚菌酯[J].世界农药,2006,(6):51-52.
[3]徐浩,李振,赵华,等.新农药苯醚菌酯(ZJ0712)在黄瓜及土壤中的残留研究[J].农业环境科学学报,2006(b09):595-598.
[4]Wang L K,Zhao J H,Laura D M,et al.Degradation and metabolic profiling for benzene kresoxim-methyl using carbon-14 tracing[J].Science of The Total Environment,2018,637-638:1221-1229.
[5]Zhao J H,Wang L K,Cheng J L,et al.Fate characterization of benzene kresoxim-methyl(a strobilurin fungicide)in different aerobic soils[J].Journal of Environment Quality,2017,46(3):546-552.
[6]BCPC(British Crop Production Council).e-Pesticide Manual version 6.0[DB/CD].Hampshire:BCPC(British Crop Production Council),2012-11.
[7]Fungicide Resistance Action Committee(FRAC).SDHIfungicides>Introduction and General Information[EM/OL].[2019-01-28].http://www.frac.info/working-group/sdhi-fungicides/introduction-and-general-information.
[8]Dave W B,John M C,Jeremy R G,et al.The strobilurin fungicides[J].Pest Management Science,2002,7(7):649-662.
[9]陈定花,朱卫刚,胡伟群,等.新型广谱杀菌剂苯醚菌酯(ZJ0712)生物活性[J].农药,2006,45(1):18-21.
[10]王海强,周俞辛,王景元,等.水稻稻瘟病菌不同发育阶段对7种QoI类杀菌剂的敏感性[J].农药学学报,2009,11(4):434-440.
[11]周俞辛,杨云碧,张彧,等.荔枝霜疫霉不同发育阶段对4种QoI类杀菌剂的敏感性[J].农药学学报,2016,18(1):57-64.
[12]陈定花,朱卫刚,胡伟群,等.新型广谱杀菌剂苯醚菌酯(ZJ0712)生物活性[J].农药,2006,45(1):18-21.
[13]侯欣,陈国庆,王兴红,等.3种柑橘病原真菌对苯醚菌酯和苯醚甲环唑敏感基线研究[J].浙江大学学报(农业与生命科学版),2013,39(1):62-68.
[14]朱卫刚,胡伟群,张蕊蕊,等.5种新型杀菌剂对草莓白粉病的生物活性研究[J].中国南方果树,2014,43(3):114-115.
[15]金丽华,陈长军,王建新,等.嘧菌酯及SHAM对4种植物病原真菌的活性和作用方式研究[J].中国农业科学,2007,(10):2206-2213.
[16]王敏,韩平,卢晓红,等.黄瓜白粉病菌对苯醚菌酯敏感基线的建立及室内抗药性风险评价[J].植物病理学报,2007,37(6):660-665.
[17]胡伟群,陈定花,朱卫刚,等.抗苯醚菌酯(ZJ0712)小麦白粉病菌突变体的诱导及其生物学特性[J].农药学学报,2009,11(2):203-207.
[18]杜飞,缪钱江,梅馨月,等.葡萄霜霉病菌对主要杀菌剂的抗性监测[C].中国植物病理学会学术年会,2015.
[19]Zhou Y X,Chen L,Hu J,et al.Resistance mechanisms and molecular docking studies of four novel QoI fungicides in peronophythora litchi[J].Scientific Reports,2015,5:17466.
[20]Zhou Y X,Chen L,Hu J,et al.Baseline sensitivity of natural population and resistance risk ofPeronophythora litchiito four novel QoI fungicides[J].European Journal of Plant Pathology,2016,146(1):71-83.
[21]胡伟群,朱卫刚,张蕊蕊,等.灰葡萄孢多药抗性菌株的筛选和鉴定[J].农药学学报,2011,13(6):586-590.
[22]沈剑仕,曹根法,张新忠,等.苯醚菌酯的合成方法[J].农药,2014,53(10):718-719.
[23]韩萍,郑舟,周坤英,等.苯醚菌酯(ZJ0712)的高效液相色谱分析[J].农药,2012,51(2):117-118.
[24]陈定花,胡伟群,朱卫刚,等.新型广谱杀菌剂10%苯醚菌酯SC(ZJ0712)应用技术[J].农药,2006,45(3):162-164.
[25]李进京,叶春雷,谢志军.5种药剂对胡麻白粉病的防效[J].甘肃农业科技,2015,(9):46-48.
[26]徐暄,孙其文,王永强.几种新型药剂对西瓜白粉病的防治效果研究[J].安徽农学通报,2015,(15):83-84.
[27]王萍莉.10%苯醚菌酯悬浮剂对籽用西瓜白粉病的药效研究[J].北方园艺,2012,(22):131-132.
[28]尤爱琴,张昌杰,胡宇峰,等.5种杀菌剂对小麦赤霉病的防治效果初探[J].浙江农业科学,2012,1(4):532-535.
[29]王志鹏,王建玉,段祥坤.不同药剂对甜瓜白粉病的防效研究[J].新疆农垦科技,2017,40(7):34-35.
[30]韩盛,杨渡,李承业,等.打瓜白粉病药剂防治技术研究[J].新疆农业科学,2012,49(1):101-104.
[31]胡凤云,蒋妮,叶云峰,等.积雪草漆斑病病原鉴定及室内药剂筛选[J].广西植物,2016,36(8):993-999.
[32]徐桂方,陈二龙,姜国庆,等.早稻稻瘟病田间药效试验[J].植物医生,2015(4):32-33.
[33]陈二龙,刘惠英,甘琴,等.7种药剂防治中稻稻瘟病试验[J].植物医生,2016,29(11):52-54.
[34]涂勇.雪莲果镰刀叶斑病病原菌鉴定及杀菌剂室内毒力测定[J].江苏农业科学,2014,42(12):179-181.
[35]高海峰,王锁牢,努尔孜亚·亚力买买提,等.果麦间作模式下小麦叶锈病田间消长规律及药剂防治试验[J].新疆农业科学,2015,52(3):487-492.
[36]许勇华,胡冬松,高云英,等.3种有机硅助剂对2种水性化农药制剂的增效作用[J].现代农药,2011,10(3):20-23.
[37]严凯,费礼婵,杨泽宏.葡萄霜霉病的田间调查及防治效果研究[J].农业研究与应用,2015,156(1):36-38.
[38]金向红,张登科,黄松其,等.50%苯醚菌酯干悬浮剂配方研制[J].农药,2014,(1):23-25.
[39]陈定花,朱卫刚,胡伟群,等.苯醚菌酯?戊唑醇防治白粉病生物活性[J].农药,2009,48(7):527-528.
[40]朱卫刚,陈定花,胡伟群,等.苯醚菌酯·霜霉威防治黄瓜霜霉病生物活性[J].农药,2009,48(9):694-695.
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