联用盐酸羟考酮与盐酸曲马多对进行剖宫产手术后的产妇实施静脉自控镇痛的效果

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英文篇名：Effect of oxycodone hydrochloride and tramadol hydrochloride for patient-controlled intravenous analgesia to the puerperal in caesarean process 作者：朱志刚 英文作者：Zhu zhi gang;department of anesthesiology,shuangnan hospital,chengdu; 关键词：盐酸羟考酮 ; 枸橼酸舒芬太尼 ; 盐酸曲马多 ; 盐酸托烷司琼 ; 剖宫产手术 ; 术后静脉自控镇痛 英文关键词：oxycodone hydrochloride;;Sufentanil citrate;;Tramadol hydrochloride;;Tolansetron hydrochloride;;Cesarean section;;Postoperative controlled intravenous analgesia 中文刊名：QYWA 英文刊名：Contemporary Medical Symposium 机构：成都双楠医院麻醉科; 出版日期：2019-04-15 出版单位：当代医药论丛 年：2019 期：v.17 语种：中文; 页：QYWA201908004 页数：2 CN：08 ISSN：22-1407/R 分类号：13-14

摘要

目的 :探讨联用盐酸羟考酮与盐酸曲马多对进行剖宫产手术后的产妇实施静脉自控镇痛的效果。方法 :选取2017年11月至2018年3月期间在成都双楠医院进行剖宫产手术的80例产妇作为研究对象。将这些产妇平均分为试验组和对照组。进行剖宫产手术后,均为这些产妇注射盐酸托烷司琼。在此基础上,用30 mg的盐酸羟考酮和500 mg的盐酸曲马多对试验组产妇进行静脉自控镇痛,用100μg的枸橼酸舒芬太尼和500mg的盐酸曲马多对对照组产妇进行静脉自控镇痛。然后比较两组产妇镇痛的效果。结果 :在手术后6h、12h、24h、48h,试验组产妇切口VAS评分、宫缩VAS评分均低于对照组产妇(P <0.05)。在手术后6h、12h,试验组产妇按压自控镇痛泵的次数均少于对照组产妇(P <0.05)。试验组产妇不良反应的发生率低于对照组产妇,但二者相比,P>0.05。结论 :联用盐酸羟考酮与盐酸曲马多对进行剖宫产手术后的产妇实施静脉自控镇痛的效果较为理想,安全性较高。
        objective: to investigate the effect of combined administration of oxycodone hydrochloride and tramadol hydrochloride on parturient patients with controlled intravenous analgesia after cesarean section. Methods: 80 parturients who underwent cesarean section in chengdu shuangnan hospital from November 2017 to March 2018 were selected as research objects. The women were equally divided into a trial group and a control group. After cesarean section, these women were injected with toransetron hydrochloride. On this basis, 30 mg of oxycodone hydrochloride and 500 mg of tramadol hydrochloride were used for pca in the experimental group,and 100 g of sufentanil citrate and 500 mg of tramadol hydrochloride were used for pca in the control group. Then compare the analgesic effect between the two groups.Results: at 6 h, 12 h, 24 h and 48 h after surgery, the incision VAS score and uterine VAS score of the experimental group were lower than those of the control group(P< 0.05). At 6 h and 12 h after surgery, the number of pca pump presses in the experimental group was less than that in the control group(P < 0.05). The incidence of adverse reactions in the experimental group was lower than that in the control group, but P > was 0.05. Conclusion: combined administration of oxycodone hydrochloride and tramadol hydrochloride is effective and safe in parturient women undergoing cesarean section.

引文

[1]宋志刚,梁太汉.罗哌卡因分别与吗啡和舒芬太尼用于剖宫产手术麻醉术后镇痛的临床效果观察[J].中国医药指南,2013,11(1):161-162.
    [2]许庆,张巍,李江,等.氟比洛芬脂复合芬太尼用于剖宫产术后静脉镇痛的临床观察[J].浙江临床医学,2015,17(1):137-138.
    [3]朱国松,韩雪,张加强.比较羟考酮和舒芬太尼对腹腔镜下宫颈癌根治术患者免疫功能的影响[J].新医学,2017,48(8):555-559.
    [4]Boland JW,Foulds GA,Ahmedzai SH,et al.A preliminary evaluation of the effects of opioids on innate and adaptive human in vitro immune function[J].BMJ Support Palliat Care,2014,4(4):357-367.
    [5]Uysal HY,Takmaz SA,Yaman F,et a1.The efficacy of intravenous paracetamol versus tramadol for postoperative analgesia after adenotonsillectomy in children[J].Clin Anesth,2011,23(1):53-57.
    [6]朱明炜,曹金铎,祝学光,等.托烷司琼治疗腹部手术后恶心、呕吐的多中心随机对照研究[J].中国临床药理学杂志,2003,19(2):96-99.