基于集对分析偏联系数研究银屑病皮损对疗效的影响
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摘要
目的:探讨用集对分析中的偏联系数研究银屑病患者皮损程度与部位对疗效的影响。方法:首先把皮损状况分成红斑、鳞屑、浸润、面积、部位5个大类12个子类,统计202例患者在各子类上的痊愈、显效、有效、无效百分比,令其依次对应于四元联系数中的同一度a,偏同度b,偏反度c,对立度d;计算各子类疗效的四元联系数的全偏联系数,根据全偏联系数值的大小做出排序,全偏联系数值大的疗效好于全偏联系数值小的疗效,据此确定皮损状况对疗效的影响性质与影响程度。结果:浸润积分0～1.46的患者疗效最好(排序1),鳞屑积分>2.04的患者疗效最差(排序12);相对于皮损状况来说,皮损发生在何部位对治疗后的预期影响不大,但所有的皮损状况项目都不利于疗效的提高(反映在三阶全偏联系数上的值全部为负值),这与临床实际一致。结论:利用四元联系数的全偏联系数研究银屑病皮损状况对中西医结合治疗银屑病疗效的影响,在临床中根据皮损部位及皮损程度作出统计学意义上的疗效预期,从而为临床治疗提供一种新的决策支持技术。
Objective: To investigate the influence of the degree and location of lesions on the therapeutic effect in patients with psoriasis by partial association coefficient in set pair analysis.Methods: First, the skin lesions include five categories like erythema, scales, infiltration, area and locations and 12 sub categories. We counted 202 patients in each sub category on the recovery, effective, effective and invalid percentage, corresponding to the same number of four-element connection number in the same degree A,the partial similarity B, the partial inverse Cand the opposite degree D. We calculated the curative effect of four-element connection number in total deviation coefficient, making sorts according to numerical size of total deviation coefficient. The effect of numerical total deviation coefficient efficacy was better than that of the small one, and we determined the extent of the influence of skin lesions on the curative effect and the influence degree.Results: The scores of erythema in patients 0-1.46 got the best curative effect(Rank 1) and the scores of scales in patients >2.04 got the worst curative effect(Rank 12). Compared to the skin lesions, the location of the skin lesion was not significant afterreatment, but all the lesions were not conducive to the improvement of the curative effect(the value of the three order total deviation coefficient was all negative), which was in accordance with the clinical practice.Conclusion: Using the four-element connection number in total deviation coefficient to study the influence of psoriasis skin lesions on the curative effect of psoriasis treated with integrated traditional Chinese and Western medicine can make statistical significance of the expected effect according to the degree of skin lesions and lesions in clinic. It can provide a new decision support technology for clinical treatment.
Objective: To investigate the influence of the degree and location of lesions on the therapeutic effect in patients with psoriasis by partial association coefficient in set pair analysis.Methods: First, the skin lesions include five categories like erythema, scales, infiltration, area and locations and 12 sub categories. We counted 202 patients in each sub category on the recovery, effective, effective and invalid percentage, corresponding to the same number of four-element connection number in the same degree A,the partial similarity B, the partial inverse Cand the opposite degree D. We calculated the curative effect of four-element connection number in total deviation coefficient, making sorts according to numerical size of total deviation coefficient. The effect of numerical total deviation coefficient efficacy was better than that of the small one, and we determined the extent of the influence of skin lesions on the curative effect and the influence degree.Results: The scores of erythema in patients 0-1.46 got the best curative effect(Rank 1) and the scores of scales in patients >2.04 got the worst curative effect(Rank 12). Compared to the skin lesions, the location of the skin lesion was not significant afterreatment, but all the lesions were not conducive to the improvement of the curative effect(the value of the three order total deviation coefficient was all negative), which was in accordance with the clinical practice.Conclusion: Using the four-element connection number in total deviation coefficient to study the influence of psoriasis skin lesions on the curative effect of psoriasis treated with integrated traditional Chinese and Western medicine can make statistical significance of the expected effect according to the degree of skin lesions and lesions in clinic. It can provide a new decision support technology for clinical treatment.
引文
[1] 徐蓉,王洁,李福伦,等.加味芩珠凉血方及辨证加减治疗寻常型银屑病(血热证)的临床疗效观察[J].时珍国医国药,2012,23(2):424-426.
[2] 范斌,李峰,李欣,等.血热证银屑病患者Th17细胞与相关转导因子的表达[J].时珍国医国药,2012,23(10):2612-2614.
[3] 李峰,迮侃,曹筱筱,等.应用集对分析法构建寻常型银屑病血热证辨证模型[J].中国中西医结合杂志,2012,32(10):1308-1312.
[4] 孙传兴.临床疾病诊断依据治愈好转标准[S].北京:人民军医出版社,1998:204.
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[7] 赵克勤.偏联系数[C]//中国人工智能进展.北京:北京邮电大学出版社,2005:884-886.
[8] 赵克勤,赵森烽.奇妙的联系数[M].北京:知识产权出版社,2014:28-30.
[9] 蒋云良,赵克勤,刘以安,等.信息处理集对分析[M].北京:清华大学出版社,2014:23-25.
[10] 刘秀梅,赵克勤.区间数决策集对分析[M].北京:科学出版社,2014:46-48.
[11] 李峰,李欣,迮侃,等.寻常型银屑病血热证的辨证因子初探[J].新中医,2012,44(10):57-60.
[12] 李斌,徐蓉,李福伦,等.基于联系数的痛风性关节炎血瘀证辨证因子研究[J].中西医结合学报,2009,7(8):724-728.
[13] 李峰,迮侃,曹筱筱,等.应用集对分析法构建寻常型银屑病血热证辨证模型[J].中国中西医结合杂志,2012,32(10):1308-1312.
[14] 李欣,李斌,李福伦,等.寻常型银屑病进行期血热证与方药的相关性研究[J].中医杂志,2012,53(10):843-847.
[15] 李欣,徐蓉,周敏,等.基于集对分析的寻常型银屑病方证相关性研究[J].辽宁中医杂志,2012,39(6):974-978.
[16] 李欣,蒯仂,许逊哲,等.基于集对分析的疗效曲线在银屑病血热证药物选优中的应用[J].新中医,2017,49(10):107-111.
[17] 洪锡京,许逊哲,蒯仂,等.基于集对分析势值成果的寻常型银屑病血热证临床再研究[J].中华中医药杂志,2018,33(3):1160-1163.
[18] 刘芳,庞晓文,朱赛楠.银屑病患者瘙痒特征及其对生活质量的影响[J].中国麻风皮肤病杂志,2014,30(6):335-337.
[19] 余国祥.对联系数中的不确定数i的研究[J].辽宁师范大学学报,2002,25(4):349-352
[20] 朱兵,王文圣,王红芳,等.集对分析中差异不确定系数i的探讨[J].四川大学学报,2008,34(1):5-9.
[21] 吴亭.联系数a+bi中不确定系数i的一个取值公式及应用[J].科技通报,2008,24(5):595-597.
[2] 范斌,李峰,李欣,等.血热证银屑病患者Th17细胞与相关转导因子的表达[J].时珍国医国药,2012,23(10):2612-2614.
[3] 李峰,迮侃,曹筱筱,等.应用集对分析法构建寻常型银屑病血热证辨证模型[J].中国中西医结合杂志,2012,32(10):1308-1312.
[4] 孙传兴.临床疾病诊断依据治愈好转标准[S].北京:人民军医出版社,1998:204.
[5] 国家中医药管理局.中医病证诊断疗效特性[M].南京:南京大学出版社,1994.
[6] 赵克勤.集对分析及其初步应用[M].杭州:浙江科学技术出版社,2000:9-42.
[7] 赵克勤.偏联系数[C]//中国人工智能进展.北京:北京邮电大学出版社,2005:884-886.
[8] 赵克勤,赵森烽.奇妙的联系数[M].北京:知识产权出版社,2014:28-30.
[9] 蒋云良,赵克勤,刘以安,等.信息处理集对分析[M].北京:清华大学出版社,2014:23-25.
[10] 刘秀梅,赵克勤.区间数决策集对分析[M].北京:科学出版社,2014:46-48.
[11] 李峰,李欣,迮侃,等.寻常型银屑病血热证的辨证因子初探[J].新中医,2012,44(10):57-60.
[12] 李斌,徐蓉,李福伦,等.基于联系数的痛风性关节炎血瘀证辨证因子研究[J].中西医结合学报,2009,7(8):724-728.
[13] 李峰,迮侃,曹筱筱,等.应用集对分析法构建寻常型银屑病血热证辨证模型[J].中国中西医结合杂志,2012,32(10):1308-1312.
[14] 李欣,李斌,李福伦,等.寻常型银屑病进行期血热证与方药的相关性研究[J].中医杂志,2012,53(10):843-847.
[15] 李欣,徐蓉,周敏,等.基于集对分析的寻常型银屑病方证相关性研究[J].辽宁中医杂志,2012,39(6):974-978.
[16] 李欣,蒯仂,许逊哲,等.基于集对分析的疗效曲线在银屑病血热证药物选优中的应用[J].新中医,2017,49(10):107-111.
[17] 洪锡京,许逊哲,蒯仂,等.基于集对分析势值成果的寻常型银屑病血热证临床再研究[J].中华中医药杂志,2018,33(3):1160-1163.
[18] 刘芳,庞晓文,朱赛楠.银屑病患者瘙痒特征及其对生活质量的影响[J].中国麻风皮肤病杂志,2014,30(6):335-337.
[19] 余国祥.对联系数中的不确定数i的研究[J].辽宁师范大学学报,2002,25(4):349-352
[20] 朱兵,王文圣,王红芳,等.集对分析中差异不确定系数i的探讨[J].四川大学学报,2008,34(1):5-9.
[21] 吴亭.联系数a+bi中不确定系数i的一个取值公式及应用[J].科技通报,2008,24(5):595-597.
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