艾灸治疗艾滋病相关性腹泻的机制探讨与展望
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摘要
艾滋病相关性腹泻是艾滋病发展过程中的一种常见并发症,可出现如吸收障碍、体重下降、脓毒血症甚至死亡等严重的临床症状,并对艾滋病病毒感染者和艾滋病病人的生活质量产生重大影响。胃肠道免疫功能缺陷和肠道微生物失调被认为是艾滋病相关性腹泻的两大主要原因。近年来研究显示,艾灸在治疗艾滋病相关性腹泻方面取得较好疗效,本文试图从上述两大发病机制入手,探讨艾灸治疗艾滋病相关性腹泻的疗效机制,并对艾灸、经皮电刺激、激光/刺激等"类针刺"疗法在传染类疾病诊疗中的应用提出新的展望。
Acquired immune deficiency syndrome(AIDS) associated diarrhea is a common complication during the development of AIDS, which will not only lead to a serious of clinical symptoms, such as malabsorption, weight losing, septicopyemia and even death, but also cause a great influence on the living quality of the patients with HIV/AIDS. Gastrointestinal immune dysfunction and intestinal microbial disturbance are two main causes of AIDS-associated diarrhea. Recent researches show that moxibustion is effective in the treatment of AIDS associated diarrhea. This paper aims to explore the therapeutic mechanism of moxibustion on the treatment of AIDS-associated diarrhea and propose a new and broad prospects of moxibustion, transcutaneous electric stimulation and laser stimulation on the infectious diseases.
Acquired immune deficiency syndrome(AIDS) associated diarrhea is a common complication during the development of AIDS, which will not only lead to a serious of clinical symptoms, such as malabsorption, weight losing, septicopyemia and even death, but also cause a great influence on the living quality of the patients with HIV/AIDS. Gastrointestinal immune dysfunction and intestinal microbial disturbance are two main causes of AIDS-associated diarrhea. Recent researches show that moxibustion is effective in the treatment of AIDS associated diarrhea. This paper aims to explore the therapeutic mechanism of moxibustion on the treatment of AIDS-associated diarrhea and propose a new and broad prospects of moxibustion, transcutaneous electric stimulation and laser stimulation on the infectious diseases.
引文
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[20]农惠玲,时宗泽.隔姜灸治疗艾滋病腹泻的临床研究[J].中国医药导报,2016,13(16):101-103,111.
[21] 王凤玲,李蕙,魏正灿,等.灸神阙穴对中老年人免疫功能及其全身状态的影响[J].中国针灸,1996,16(7):39-40.
[22] 施茵,吴焕淦.足三里穴在免疫功能调节中的应用[J].现代中医药,2003(3):3-6.
[23] 谢甦,李丽红,吕明庄.艾灸关元、足三里对衰老小鼠免疫功能影响的实验研究[J].贵阳中医学院学报,2003,25(2):44-46.
[24] 吴炳煌,林宏,阙庆辉,等.隔姜灸神朗治疗慢性腹泻疗效与免疫功能的关系[J].福建中医学院学报,1997,7(3):20-21.
[25] 孙可一.乳酸杆菌的分离鉴定及其对炎症反应的免疫调节作用的研究[D].南京:南京医科大学,2012.
[26] 王婷婷,王雪芹,霍贵成.乳酸杆菌对感染大肠杆菌O157:H7小鼠肠道黏膜免疫的影响[J].微生物学通报,2014,41(10):2082-2089.
[27] Wang XM,Lu Y,Wu LY,et al.Moxibustion inhibits interleukin-12 and tumor necrosis factor alpha and modulates intestinal flora in rat with ulcerative colitis[J].World J Gastroenterol,2012,18 (46):6826-6835.
[2] Tramarin A,Parise N,Campostrini S,et al.Association between diarrhea and quality of life in HIV-infected patients receiving highly active antiretroviral therapy[J].Qual Life Res,2004(13):243-250.
[3] Siddiqui U,Bini EJ,Chandarana K,et al.Prevalence and impact of diarrhea on health-related quality of life in HIV-infected patients in the era of highly active antiretroviral therapy[J].J Clin Gastroenterol,2007(41):484-490.
[4] Zingmond DS,Kilbourne AM,Justice AC,et al.Differences in symptom expression in older HIV-positive patients:the veterans aging cohort 3 site study and HIV cost and service utilization study experience[J].J Acquir Immune Defic Syndr,2003,33 (Suppl 2):S84-S92.
[5] Logan Clare,Beadsworth Mike BJ,Beeching Nick J.HIV and diarrhoea:what is new[J].Curr Opin Infect Dis,2016(29):486-494.
[6] 中国中医科学院中医药防治艾滋病研究中心,中华中医药学会艾滋病分会.艾滋病中医药治疗手册[M].北京:中医古籍出版社,2014:71.
[7] Tincati C,Douek DC,Marchetti G.Gut barrier structure,mucosal immunity and intestinal microbiota in the pathogenesis and treatment of HIV infection[J].AIDS Res Ther,2016(11):13-19.
[8] Raffatellu M,Santos RL,Verhoeven DE,et al.Simian immunodeficiency virus induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut[J].Nat Med,2008(14):421-428.
[9] Bhaijee F,Subramony C,Tang SJ,et al.Human immunodeficiency virus-associated gastrointestinal disease:common endoscopic biopsy diagnoses[J].Patholog Res Int,2011(2011):247923.
[10] Zevin AS,McKinnon L,Burgener A,et al.Microbial translocation and microbiome dysbiosis in HIV-associated immune activation[J].Curr Opin HIV AIDS,2016(11):182-190.
[11] Dillon SM,Lee EJ,Donovan AM,et al.Enhancement of HIV-1 infection and intestinal CD4t T cell depletion ex vivo by gut microbes altered during chronic HIV-1 infection[J].Retrovirology,2016(14):5.
[12] 赵继梦,黄艳,窦传字,等.艾灸疗法:在调节肠易激综合征肠道菌群与黏膜免疫中的展望[J].中国组织工程研究,2015,19(2):289-293.
[13] 王磊.艾灸疗法作用机理国内外研究进展[J].中国针灸,2001,21(9):567-570.
[14] 赵丹,李峰,张宁.中医非药物疗法防治艾滋病研究进展[J].北京中医药大学学报,2006,29(1):63-66.
[15] 郭燕,钱宝延,艾灸治疗艾滋病腹泻60例观察[J].河南中医学院院报,2005,20(4):6-7.
[16] 周立华,唐英,卢依平,等.艾灸法治疗艾滋病脾气虚腹泻的临床研究[J].上海针灸杂志,2008,27(5):17-19.
[17] 李静茹.艾灸治疗艾滋病腹泻临床疗效观察[C].中华中医药学会中华中医药学会防治艾滋病分会2016年学术会议论文集,2016:4.
[18] 周立华,李媛.艾灸神阙、关元、足三里治疗艾滋病腹泻的机理研究[J].光明中医,2010,25(4):648-649.
[19] 陈秀敏.艾滋病腹泻的艾灸应用及护理观察[J].中国中医药现代远程教育,2009,7(6):166-167.
[20]农惠玲,时宗泽.隔姜灸治疗艾滋病腹泻的临床研究[J].中国医药导报,2016,13(16):101-103,111.
[21] 王凤玲,李蕙,魏正灿,等.灸神阙穴对中老年人免疫功能及其全身状态的影响[J].中国针灸,1996,16(7):39-40.
[22] 施茵,吴焕淦.足三里穴在免疫功能调节中的应用[J].现代中医药,2003(3):3-6.
[23] 谢甦,李丽红,吕明庄.艾灸关元、足三里对衰老小鼠免疫功能影响的实验研究[J].贵阳中医学院学报,2003,25(2):44-46.
[24] 吴炳煌,林宏,阙庆辉,等.隔姜灸神朗治疗慢性腹泻疗效与免疫功能的关系[J].福建中医学院学报,1997,7(3):20-21.
[25] 孙可一.乳酸杆菌的分离鉴定及其对炎症反应的免疫调节作用的研究[D].南京:南京医科大学,2012.
[26] 王婷婷,王雪芹,霍贵成.乳酸杆菌对感染大肠杆菌O157:H7小鼠肠道黏膜免疫的影响[J].微生物学通报,2014,41(10):2082-2089.
[27] Wang XM,Lu Y,Wu LY,et al.Moxibustion inhibits interleukin-12 and tumor necrosis factor alpha and modulates intestinal flora in rat with ulcerative colitis[J].World J Gastroenterol,2012,18 (46):6826-6835.
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