津力达颗粒对冠心病合并2型糖尿病患者血管内皮功能的影响
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摘要
目的探讨津力达颗粒对冠心病合并2型糖尿病患者血管内皮功能的影响。方法选取2017年3月～2018年3月我院收治的73例冠心病合并2型糖尿病患者作为研究对象,根据随机数字表法分为观察组(43例)和对照组(30例)。对照组采用常规西药治疗,同时根据患者血糖情况采用口服降糖药或胰岛素治疗。观察组在上述治疗基础上加用津力达颗粒。比较两组患者治疗前后的空腹血糖水平及血管内皮功能指标水平:血管内皮生长因子(VEGF)、内皮素-1(ET-1)、一氧化氮(NO)。结果两组患者治疗后的空腹血糖、ET-1水平均低于治疗前,VEGF、NO水平均高于治疗前,差异有统计学意义(P<0.05);观察组患者治疗后的空腹血糖、ET-1水平均低于对照组,VEGF、NO水平均高于对照组,差异有统计学意义(P<0.05)。结论津力达颗粒可有效协同西药降低患者的血糖水平,改善患者的血管内皮功能,有效改善冠心病合并2型糖尿病患者病情的发生发展。
Objective To investigate the effect of Jinlida Granule on vascular endothelial function in patients with coronary heart disease complicated with type 2 diabetes mellitus. Methods A total of 73 patients with coronary heart disease complicated with type 2 diabetes mellitus admitted to our hospital from March 2017 to March 2018 were selected as the study subjects, according to the random number table method, they were divided into observation group(43 cases) and control group(30 cases). The control group was treated with routine western medicine and oral hypoglycemic drugs or insulin according to blood sugar, the observation group was treated with Jinlida Granule on the basis of the above treatment. The levels of fasting blood glucose and vascular endothelial function indexes before and after treatment were compared between the two groups: vascular endothelial growth factor(VEGF), endothelin-1(ET-1), nitric oxide(NO). Results The levels of fasting blood sugar and ET-1 after treatment in both groups were lower than those before treatment, and the levels of vascular endothelial growth factor and nitric oxide were higher than those before treatment, the differences were statistically significant(P<0.05). The levels of fasting blood sugar and ET-1 in the observation group were lower than those in the control group, and the levels of vascular endothelial growth factor and nitric oxide in the observation group were higher than those in the control group, the differences were statistically significant(P<0.05). Conclusion Jinlida Granule can effectively cooperate with western medicine to reduce blood sugar level, improve vascular endothelial function, and effectively improve the occurrence and development of coronary heart disease complicated with type 2 diabetes mellitus.
Objective To investigate the effect of Jinlida Granule on vascular endothelial function in patients with coronary heart disease complicated with type 2 diabetes mellitus. Methods A total of 73 patients with coronary heart disease complicated with type 2 diabetes mellitus admitted to our hospital from March 2017 to March 2018 were selected as the study subjects, according to the random number table method, they were divided into observation group(43 cases) and control group(30 cases). The control group was treated with routine western medicine and oral hypoglycemic drugs or insulin according to blood sugar, the observation group was treated with Jinlida Granule on the basis of the above treatment. The levels of fasting blood glucose and vascular endothelial function indexes before and after treatment were compared between the two groups: vascular endothelial growth factor(VEGF), endothelin-1(ET-1), nitric oxide(NO). Results The levels of fasting blood sugar and ET-1 after treatment in both groups were lower than those before treatment, and the levels of vascular endothelial growth factor and nitric oxide were higher than those before treatment, the differences were statistically significant(P<0.05). The levels of fasting blood sugar and ET-1 in the observation group were lower than those in the control group, and the levels of vascular endothelial growth factor and nitric oxide in the observation group were higher than those in the control group, the differences were statistically significant(P<0.05). Conclusion Jinlida Granule can effectively cooperate with western medicine to reduce blood sugar level, improve vascular endothelial function, and effectively improve the occurrence and development of coronary heart disease complicated with type 2 diabetes mellitus.
引文
[1]白伟,吴欣蕊,刘建凤.益肾汤联合糖维胶囊治疗2型糖尿病肾病患者临床疗效及对VEGF、BUN影响[J].辽宁中医药大学学报,2017,19(8):102-104.
[2]白建乐,宫蕊.糖维胶囊对2型糖尿病患者脂质代谢血管内皮功能及微循环状态的影响[J].河北医学,2017,23(11):1888-1892.
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[5]吴茂红,吕玲.糖耐量异常对冠心病患者氧化应激和血管内皮功能、心率变异性的影响及阿卡波糖的干预作用[J].中国动脉硬化杂志,2014,22(3):287-292.
[6]DU Q,WU B,WANG YJ,et al.Comparative effects of sitagliptin and metformin in patients with type 2 diabetes mellitus:a meta-analysis[J].Curr Med Res Opin,2013,29(11):1487-1493.
[7]Hazman O.Effects of oral anti-diabetic agent sitagliptin on total antioxidant and oxidant status in rats with type 2 diabetes mellitus[J].J Applied Biol Sci,2014,8(1):31-37.
[8]陶文玉.血管内皮生长因子与糖尿病肾病的研究新进展[J].疑难病杂志,2012,11(4):312-314.
[9]江小萍,曾凡鹏,刘首明,等.三七总皂苷对血脂异常动脉粥样硬化患者血管内皮功能及单核细胞NF-κB表达的影响[J].中西医结合心脑血管病杂志,2016,14(7):682-685.
[10]Favero G,Paganelli C,Buffoli B,et al.Endothelium and its alterations in cardiovascular diseases:life style intervention[J].Biomed Res Int,2014,2014(2):801-896.
[11]Lixandru D,Bacanu EV,Virgolici B,et al.Changes in the serum proinflammatory cytokines in patients with elevated HOMA-IR and type 2 diabetes mellitus[J].Farmacia,2015,63(1):132-139.
[12]Yazdani SK,Nakano M,Otsuka F,et al.Accelerating endothelialization of coronary stents by capturing circulating endothelial progenitor cells[J].Int Cardiol,2017,4(2):169-181.
[13]张华春.津力达颗粒对2型糖尿病患者并发微血管病变的防治作用研究[J].社区中医药,2018,34(21):99-100.
[14]Ba dulescu O,Ba descu C,Ciocoiu M,et al.Interleukin-1-beta and dyslipidemic syndrome as major risk factors for thrombotic complications in type 2 diabetes mellitus[J].Mediators Inflamm,2013,2013(5):63-72.
[15]敖勇,罗杨,杨建,等.丹参注射液对冠心病患者血清LPO、SOD、NO及MDA的影响[J].中国生化药物杂志,2016,36(1):139-140.
[2]白建乐,宫蕊.糖维胶囊对2型糖尿病患者脂质代谢血管内皮功能及微循环状态的影响[J].河北医学,2017,23(11):1888-1892.
[3]Guan Q,Liu W,Liu Y,et al.High glucose induces the release of endothelin-1 through the inhibition of hydrogen sulfide production i1n HUVECs[J].Int J Molec Med,2015,35(3):810.
[4]Borilova LP,Kastovsky J,Lucanova S,et al.Interleukin-17A gene variability in patients with type 1 diabetes mellitus and chronic periodontitis:its correlation with IL-17 levels and the occurrence of periodontopathic bacteria[J].Med Inflamm,2016,2016(4):1-9.
[5]吴茂红,吕玲.糖耐量异常对冠心病患者氧化应激和血管内皮功能、心率变异性的影响及阿卡波糖的干预作用[J].中国动脉硬化杂志,2014,22(3):287-292.
[6]DU Q,WU B,WANG YJ,et al.Comparative effects of sitagliptin and metformin in patients with type 2 diabetes mellitus:a meta-analysis[J].Curr Med Res Opin,2013,29(11):1487-1493.
[7]Hazman O.Effects of oral anti-diabetic agent sitagliptin on total antioxidant and oxidant status in rats with type 2 diabetes mellitus[J].J Applied Biol Sci,2014,8(1):31-37.
[8]陶文玉.血管内皮生长因子与糖尿病肾病的研究新进展[J].疑难病杂志,2012,11(4):312-314.
[9]江小萍,曾凡鹏,刘首明,等.三七总皂苷对血脂异常动脉粥样硬化患者血管内皮功能及单核细胞NF-κB表达的影响[J].中西医结合心脑血管病杂志,2016,14(7):682-685.
[10]Favero G,Paganelli C,Buffoli B,et al.Endothelium and its alterations in cardiovascular diseases:life style intervention[J].Biomed Res Int,2014,2014(2):801-896.
[11]Lixandru D,Bacanu EV,Virgolici B,et al.Changes in the serum proinflammatory cytokines in patients with elevated HOMA-IR and type 2 diabetes mellitus[J].Farmacia,2015,63(1):132-139.
[12]Yazdani SK,Nakano M,Otsuka F,et al.Accelerating endothelialization of coronary stents by capturing circulating endothelial progenitor cells[J].Int Cardiol,2017,4(2):169-181.
[13]张华春.津力达颗粒对2型糖尿病患者并发微血管病变的防治作用研究[J].社区中医药,2018,34(21):99-100.
[14]Ba dulescu O,Ba descu C,Ciocoiu M,et al.Interleukin-1-beta and dyslipidemic syndrome as major risk factors for thrombotic complications in type 2 diabetes mellitus[J].Mediators Inflamm,2013,2013(5):63-72.
[15]敖勇,罗杨,杨建,等.丹参注射液对冠心病患者血清LPO、SOD、NO及MDA的影响[J].中国生化药物杂志,2016,36(1):139-140.
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