铁基纳米粒子制备及用于pH响应双模态磁共振成像引导下肿瘤光热治疗

详细信息    查看全文 | 推荐本文 |

英文篇名：Facile Synthesis of Biocompatible Fe_3O_4-based Nanoparticles for pH-Responsive Dual-Model Magnetic Resonance Imaging-Guided Tumour Eradication by Photothermal Therapy 作者：刘建华 ; 王雷 ; 张天琪 ; 王建秋 ; 龚雪 ; 崔凤至 ; 郑建军 ; 李波 ; 施展 英文作者：LIU Jian-Hua;WANG Lei;ZHANG Tian-Qi;WANG Jian-Qiu;GONG Xue;CUI Feng-Zhi;ZHENG Jian-Jun;LI Bo;SHI Zhan;State Key Laboratory of Inorganic Synthesis and Preparative Chemistry,College of Chemistry,Jilin University;Department of Radiology,the Second Hospital of Jilin University;Department of Medical Imaging,Ningbo No.2 Hospital; 关键词：诊疗剂 ; 磁共振成像 ; 双模态成像 ; 近红外光 ; 光热治疗 英文关键词：Theranostic agents;;Magnetic resonance imaging;;Dual-model tumour imaging;;Near-infrared region;;Photothermal therapy 中文刊名：FXHX 英文刊名：Chinese Journal of Analytical Chemistry 机构：吉林大学化学学院无机合成与制备国家重点实验室;吉林大学第二医院放射线科;宁波市第二医院放射线科; 出版日期：2019-03-18 14:52 出版单位：分析化学 年：2019 期：v.47 基金：国家自然科学基金项目(No.81571737);; 吉林省科技厅自然科学基金项目(No.20180101119JC);; 吉林省卫计委青年基金项目(No.2017Q012);; 吉林省财政厅卫生专项基金项目(No.3D518V283429);; 宁波市重大科技专项(No.2015C50004)资助~~ 语种：中文; 页：FXHX201905005 页数：8 CN：05 ISSN：22-1125/O6 分类号：45-52

摘要

肿瘤早期诊断对于选择合适的治疗方案至关重要,而单一模态磁共振成像(MRI)难以满足精确诊断的要求。本研究构建了聚丙烯酸(PAA)修饰的Fe_3O_4@MnO_2纳米粒子(Fe_3O_4@MnO_2@PAA)用于pH响应的T_1/T_2双模态MR成像,同时能够介导肿瘤的光热治疗。以Fe_3O_4为核,可以使Fe_3O_4@MnO_2@PAA纳米粒子在磁共振成像的T_2信号明显减低; MnO_2纳米壳在肿瘤内的酸性环境下可分解为顺磁性的Mn~(2+),能够增强T_1信号。这种pH响应的T_1/T_2双模态MRI造影剂具有良好的敏感性和特异性,可以为肿瘤诊断提供更全面、更详实的信息。此外,Fe_3O_4@MnO_2@PAA纳米粒子在近红外区表现出优异的吸收能力,可作为一种良好的光热转换材料介导肿瘤的光热治疗。这种pH响应的双模态磁共振成像介导光热治疗的新型纳米诊疗剂,在肿瘤的MRI诊断及光热治疗方面表现出良好的应用潜能。
        The early accurate diagnosis is key to the successful treatment of tumours. However, single magnetic resonance imaging(MRI) mode cannot satisfy the high requirement of accurate diagnosis owing to their inherent defects. Herein, we constructed poly(acrylic) acid(PAA)-modified Fe_3O_4@MnO_2 nanoparticles(Fe_3O_4@MnO_2@PAA NPs) as a kind of pH-responsive T_1/T_2 dual-model MRI guiding photothermal therapy(PTT). Fe_3O_4 core enabled Fe_3O_4@MnO_2@PAA NPs to weaken T_2 signal in clinical MRI examination, and MnO_2 nanoshells were able to decompose into paramagnetic manganous ions under the weakly acidic environment of tumours, achieving pH-responsive T_1-weighted MRI. Such pH-responsive T_1/T_2 dual-model CAs with sensitivity and specificity provided more comprehensive information for diagnosis of tumours. Moreover, Fe_3O_4@MnO_2@PAA NPs exhibited excellent absorption in near-infrared(NIR) region, making them as good NIR photothermal agents for PTT. This work presented novel pH-responsive theranostic agents integrated dual-model imaging and PTT functionalities, and demonstrated their potential for stimuli-responsive MRI guided PTT of cancer.

引文

1 Jin X,Fang F,Liu J,Jiang C,Han X,Song Z,Chen J,Sun G,Lei H,Lu L.Nanoscale,2015,7(38):15680-15688
    2 Burstein D,Velyvis J,Scott K T,Stock K W,Kim Y J,Jaramillo D,Boutin R D,Gray M L.Magn.Reson.Med.,2001,45(1):36-41
    3 Wang S,Lin J,Wang Z,Zhou Z,Bai R,Lu N,Liu Y,Fu X,Jacobson O,Fan W,Qu J,Chen S,Wang T,Huang P,Chen X.Adv.Mater.,2017,29(35):1701013
    4 Farnsworth R H,Lackmann M,Achen M G,Stacker S A.Oncogene,2014,33(27):3496-505
    5 Kim R,Fieno D,Parrish T,Harris K,Chen E,Simonetti O,Bundy J,Finn J,Klocke F,Judd R.Circulation,1999,100(19):1992-2002
    6 Leutz-Schmidt P,Stahl M,Sommerburg O,Eichinger M,Puderbach M,Schenk J,Alrajab A,Triphan S,Kauczor H,Mall M,Wielputz M.Eur.J.Radiol.,2018,101:178-183
    7 Liu X,Jiang F,Wang Z,Li X,Li Z,Zhang X,Chen F,Mao J,Zhou L,Gui J.Sci.Rep.,2017,7(1):5395
    8 Chen Y,Ye D,Wu M,Chen H,Zhang L,Shi J,Wang L.Adv.Mater.,2014,26(41):7019
    9 Jin L,Liu J,Tang Y,Cao L,Zhang T,Yuan Q,Wang Y,Zhang H.ACS Appl.Mater.Interfaces,2017,9(48):41648-41658
    10 Wang D,Zhou J,Shi R,Wu H,Chen R,Duan B,Xia G,Xu P,Wang H,Zhou S,Wang C,Wang H,Guo Z,Chen Q.Theranostics,2017,7(18):4605-4617
    11 Mai B,Fernandes S,Balakrishnan P,Pellegrino T.Acc.Chem.Res.,2018,51(5):999-1013
    12 Yang G,Zhang R,Liang C,Zhao H,Yi X,Shen S,Yang K,Cheng L,Liu Z.Small,2018,14(2):1702664
    13 Wang Y,Song S,Liu J,Liu D,Zhang H.Angew.Chem.Int.Edit.,2015,127(2):546-550
    14 Chen Q,Feng L,Liu J,Zhu W,Dong Z,Wu Y,Liu Z.Adv.Mater.,2016,28(33):7129-7136
    15 Ding X,Liu J,Li J,Wang F,Wang Y,Song S,Zhang H.Chem.Sci.,2016,7(11):6695
    16 Liu J,Jin L,Wang Y,Ding X,Zhang S T,Song S,Wang D,Zhang H.Small,2018,14(7):1702431
    17 Zhou Z,Bai R,Munasinghe J,Shen Z,Nie L,Chen X.ACS Nano,2017,11(6):5227-5232
    18 Gai S,Yang P,Li C,Wang W,Dai Y,Niu N,Lin J.Adv.Funct.Mater.,2010,20(7):1166-1172
    19 Zhang L,Lian J,Wu L,Duan Z,Jiang J,Zhao L.Langmuir,2014,30(23):7006-7013
    20 Yi X,Chen L,Zhong X,Gao R,Qian Y,Wu F,Song G,Chai Z,Liu Z,Yang K.Nano Res.,2016,9(11):3267-3278
    21 Zhai Y,Zhai J,Zhou M,Dong S.J.Mater.Chem.,2009,19(38):7030-7035