血尿酸水平及生活环境因素与脑小血管病的相关性

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英文篇名：The Correlation between Serum Uric Acid Level and Living Environment Factors and Cerebrovascular Disease 作者：张贵强 ; 许文锋 ; 赵文婧 ; 王瑜洁 ; 杨和平 英文作者：ZHANG Gui-qiang;XU Wen-feng;ZHAO Wen-jing;WANG Yu-jie;YANG He-ping;Department of Neurology, Guangxi Nationalities Hospital;Guangxi Workers' Hospital;Department of Histology and Embryo Research, Basic Medical College, Guangxi Medical University; 关键词：尿酸 ; 脑小血管病 ; 吸氧 ; 饮酒 ; 运动 英文关键词：Uric acid;;Cerebral small vascular disease;;Oxygen absorption 中文刊名：WMIA 英文刊名：World Latest Medicine Information 机构：广西壮族自治区民族医院神经内科;广西壮族自治区工人医院;广西医科大学基础医学院组胚教研室; 出版日期：2019-04-05 出版单位：世界最新医学信息文摘 年：2019 期：v.19 基金：广西医科大学青年基金(GXMUYSF201528);; 广西高校中青年教师基础能力提升项目(2017KY0096);; 广西再生医学重点实验室开放课题资助项目(桂再重开201703) 语种：中文; 页：WMIA201928005 页数：3 CN：28 ISSN：11-9234/R 分类号：20-22

摘要

目的研究血尿酸水平及相关生活环境因素与脑小血管病发病风险的关系。方法采用病例对照研究,按照性别及年龄1:1匹配,入组病例及对照组各400例,采用问卷调查方式,收集人口学以及吸烟、饮酒、运动等生活环境信息,并采集生化样本资料,分析血尿酸水平及其环境因素联合作用下对脑小血管病发病风险的影响。结果较高的血尿酸水平能降低脑小血管病发病风险(OR=0.40,95%CI 0.26～0.64),按照性别分组后,这一相关性仍存在。血尿酸水平升高的不吸烟人群(OR=0.53,95%CI 0.38～0.79)、不饮酒人群(OR=0.49,95%CI 0.36～0.79)和运动时间超过1h/d的人群(OR=0.52,95%CI 0.36～0.78)中脑小血管病的发病风险降低,而在吸烟、饮酒人群中和运动时间小于1h/d的人群中,高尿酸水平并不能显著降低脑小血管病发病风险。结论高尿酸水平能降低脑小血管病的发病风险,生活环境因素可能促进了血尿酸对脑小血管病的保护作用。
        Objective To study the relationship between serum uric acid level and related living environment factors and risk of cerebrovascular disease. Methods Using case-control study, according to sex and age 1:1 matching, the group of cases and control group of 400 cases, the use of questionnaires to collect demographic and smoking, alcohol, sports and other living environment information, and collection of biochemical sample data, To analyze the effect of serum uric acid level and its environmental factors on the risk of cerebrovascular disease. Results High serum uric acid level can reduce the risk of cerebrovascular disease(or=0.40,95%Cl0.26-0.64), and this correlation is still present after the sex subgroup. Non-smokers with elevated uric acid levels(or=0.53,95%Cl 0.38-0.79), non-drinkers(or=0.49,95%Cl 0.36-0.79)and people with more than 1 h/d in exercise time(or=0.52,95%Cl 0.36-0.78) The risk of cerebral small vascular disease is reduced, but in people who smoke, drink and exercise time is less than 1 h/d, the high uric acid level does not reduce the risk of cerebrovascular disease significantly. Conclusion The high uric acid level can reduce the risk of cerebrovascular disease, and the living environment may modify the protective effect of uric acid on cerebral small vascular disease.

引文

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