吉西他滨联合铂类药物治疗转移性三阴乳腺癌的临床研究

详细信息    查看全文 | 推荐本文 |

英文篇名：Clinical study of gemcitabine combined with platinum in the treatment of metastatic triple negative breast cancer 作者：张春雨 英文作者：ZHANG Yuchun;Three Departments of Internal Medicine,Yichun First Hospital; 关键词：吉西他滨 ; 铂类药物 ; 转移性三阴乳腺癌 英文关键词：emcitabine;;platinum drugs;;metastatic triple negative breast cancer 中文刊名：JLDS 英文刊名：Journal of Jilin Medical University 机构：伊春市第一医院内三科; 出版日期：2019-05-08 出版单位：吉林医药学院学报 年：2019 期：v.40 语种：中文; 页：JLDS201903006 页数：2 CN：03 ISSN：22-1368/R 分类号：19-20

摘要

目的分析吉西他滨联合铂类药物治疗转移性三阴乳腺癌的结果。方法选择近一年医院接受的78例转移性三阴乳腺癌患者作为案例,随机分为1组和2组,分别实施的是常规化疗方式和吉西他滨联合铂类药物治疗,治疗后对结果分析。结果 1组和2组的总有效率分别是71.8%和92.3%,对比后2组的效果明显。对两组患者的不良反应率分析,1组和2组的不良反应率分别是15.3%和7.6%。结论在临床中对于转移性三阴乳腺癌患者实施吉西他滨联合铂类药物进行干预治疗,效果明显,值得推广。
        Objective To analyze the effect of gemcitabine combined with platinum in the treatment of metastatic triple negative breast cancer. Methods 78 patients with metastatic triple negative breast cancer in our hospital in the past year were randomly divided into 1~(st) group and 2~(nd) groups. They were treated with conventional chemotherapy and gemcitabine combined with platinum drugs respectively.The results were analyzed after treatment. Results The total effective rates of two groups were 71.8% and 92.3%,respectively,and the adverse reaction rates of two groups were 15.3% and 7.6% respectively. Conclusion Gemcitabine combined with platinum is effective in the treatment of metastatic triple negative breast cancer in clinical research,and it is worth popularizing.

引文

[1] 张莹,沈玉静,赵丽丽.吉西他滨联合铂类药物治疗转移性三阴乳腺癌的疗效观察[J].中国医院用药评价与分析,2018,18(4):493-495.
    [2] 段海波,庞丹梅,林颖欣.转移性三阴乳腺癌切除修复交叉互补基因1的表达与含铂方案化疗疗效的关系[J].广东医学,2014,35(3):384-386.
    [3] 段海波,庞丹梅,林耀东.吉西他滨联合铂类药物治疗转移性三阴乳腺癌的临床观察[J].广东医学,2012,33(11):1663-1665.
    [4] 王俊斌,杨燕,汪子书,等.长春瑞滨或吉西他滨联合顺铂治疗转移性三阴性乳腺癌的临床疗效与安全性评价[J].中国临床药理学杂志,2016,32(1):24-26.
    [5] 史晓宇,张敬,孟玮,等.吉西他滨联合奈达铂治疗蒽环类和/或紫杉类耐药的转移性三阴乳腺癌疗效观察[J].中国基层医药,2016,23(5):712-715.
    [6] 逄琳.吉西他滨联合铂类药物治疗转移性三阴乳腺癌的临床分析[J].中国医药指南,2018,16(34):157-158.