双相情感障碍患者中血清S100B、总胆红素和IL-1β、IL-4水平变化
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摘要
目的探讨双相情感障碍患者血清S100蛋白、总胆红素、白细胞介素-1β(IL-1β)和白细胞介素-4 (IL-4)水平及临床意义。方法选取2016年1月～2018年4月在北京市房山区精神卫生保健院治疗的双相情感障碍患者70例(观察组),其中躁狂发作患者30例、抑郁发作患者28例、混合发作患者12例;同时选取健康志愿者70例作为健康对照组,检测血清S100蛋白、总胆红素、IL-1β和IL-4水平。结果观察组血清S100蛋白、IL-1β和IL-4明显高于健康对照组[(0.30±0.10)g/L vs.(0.12±0.03)g/L、(4.69±1.11)ng/L vs.(1.20±0.56)ng/L和(3.83±1.03)ng/L vs.(1.31±0.78)ng/L],而总胆红素明显低于健康对照组[(7.21±1.04)μmol/L vs.(12.10±1.87)μmol/L],差异有统计学意义(P <0.05)。混合发作患者血清S100蛋白、IL-1β和IL-4分别为(0.36±0.11)g/L、(5.10±0.96)ng/L和(4.10±0.99)ng/L,明显高于躁狂发作和抑郁发作患者(P <0.05),而总胆红素为(6.83±1.03)μmol/L,明显低于躁狂发作和抑郁发作患者(P <0.05);躁狂发作和抑郁发作患者血清S100蛋白、总胆红素、IL-1β和IL-4比较差异无统计学意义(P> 0.05)。血清S100蛋白与HAMD评分、YMRS评分呈正相关(r=0.492和0.387,P <0.05)。结论双相情感障碍患者血清S100蛋白、IL-1β和IL-4水平升高,而总胆红素降低,与患者临床相有一定关系,血清S100蛋白与患者病情程度可能有关。
Objective To investigate the levels of serum S100 protein,total bilirubin,IL-1β and IL-4 in patients with bipolar affective disorder and clinical significance. Methods From January 2016 to April 2018,70 patients with bipolar affective disorder(observation group) were selected,including 30 patients with manic episode,28 patients with depressive episode and 12 patients with mixed episode;70 healthy volunteers were selected as control group;The serum S100 protein,total bilirubin,IL-1β and IL-4 levels were detected. Results The levels of serum S100 protein,IL-1β and IL-4 in the observation group were(0.30 ± 0.10)g/L,(4.69 ±1.11)ng/L and(3.83 ± 1.03)ng/L,which were significantly higher than those in the control group(P < 0.05),while the total bilirubin was(7.21 ± 1.04)μmol/L,which was significantly lower than those in the control group(P < 0.05);The serum levels of S100 protein,IL-1β and IL-4 in patients with mixed episodes were(0.36 ± 0.11)g/L,(5.10 ± 0.96)ng/L and(4.10 ± 0.99)ng/L,which were significantly higher than those in patients with manic and depressive episodes(P < 0.05),while the total bilirubin was(6.83 ± 1.03)mol/L,which was significantly lower than those in patients with manic and depressive episodes(P < 0.05);There were no significant difference in serum S100 protein,total bilirubin,IL-1β and IL-4 between manic episode and depressive episode(P > 0.05);Serum S100 protein was positively correlated with HAMD score and YMRS score(r=0.492 and 0.387,P < 0.05). Conclusion The levels of serum S100 protein,IL-1β and IL-4 in patients with bipolar affective disorder are elevated,while the level of total bilirubin are decreased,which are related to the clinical symptoms,the serum S100 protein may be related to the severity of the disease.
Objective To investigate the levels of serum S100 protein,total bilirubin,IL-1β and IL-4 in patients with bipolar affective disorder and clinical significance. Methods From January 2016 to April 2018,70 patients with bipolar affective disorder(observation group) were selected,including 30 patients with manic episode,28 patients with depressive episode and 12 patients with mixed episode;70 healthy volunteers were selected as control group;The serum S100 protein,total bilirubin,IL-1β and IL-4 levels were detected. Results The levels of serum S100 protein,IL-1β and IL-4 in the observation group were(0.30 ± 0.10)g/L,(4.69 ±1.11)ng/L and(3.83 ± 1.03)ng/L,which were significantly higher than those in the control group(P < 0.05),while the total bilirubin was(7.21 ± 1.04)μmol/L,which was significantly lower than those in the control group(P < 0.05);The serum levels of S100 protein,IL-1β and IL-4 in patients with mixed episodes were(0.36 ± 0.11)g/L,(5.10 ± 0.96)ng/L and(4.10 ± 0.99)ng/L,which were significantly higher than those in patients with manic and depressive episodes(P < 0.05),while the total bilirubin was(6.83 ± 1.03)mol/L,which was significantly lower than those in patients with manic and depressive episodes(P < 0.05);There were no significant difference in serum S100 protein,total bilirubin,IL-1β and IL-4 between manic episode and depressive episode(P > 0.05);Serum S100 protein was positively correlated with HAMD score and YMRS score(r=0.492 and 0.387,P < 0.05). Conclusion The levels of serum S100 protein,IL-1β and IL-4 in patients with bipolar affective disorder are elevated,while the level of total bilirubin are decreased,which are related to the clinical symptoms,the serum S100 protein may be related to the severity of the disease.
引文
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[5]郭晓倩,李艳,彭锐,等.心境障碍女性患者血浆白蛋白、总胆红素和尿酸心境障碍女性患者血浆白蛋白、总胆红素和尿酸水平研究水平研究[J].海南医学,2017,27(5):761-763.
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[7]中华医学会神经病学分会神经心理学与行为神经病学组,中华医学会神经病学分会帕金森病及运动障碍学组.帕金森病抑郁、焦虑及精神病性障碍的诊断标准及治疗指南[J].中华神经科杂志,2013,46(1):56-60.
[8]李则挚,汪作为,禹顺英,等.双相障碍与脑源性神经营养因子外周血mRNA和蛋白表达相关性的研究[J].中华精神科杂志,2012,45(4):213-217.
[9]黄悦琦,邱美慧,高晨阳,等.抑郁症与双相抑郁患者脑白质微结构标志物探索[J].中华精神科杂志,2017,50(2):101-106.
[2] Rasmussen MH,Str o/m M,Wohlfahrt J,et al. Risk,treatment duration,and recurrence risk of postpartum affective disorder in women with no prior psychiatric history:a population-based cohort study[J]. PLOS Med,2017,14(9):392-395.
[3] Andreano JM,Touroutoglou A,Dickerson B,et al. Hormonal cycles,brain network connectivity,and windows of vulnerability to affective disorder[J]. Trends Neurosci,2018,41(10):660-676.
[4]陶永红,张鹏,胡建.双相障碍I型血清S100B蛋白水平与认知功能的相关性[J].哈尔滨医科大学学报,2015,49(6):521-523.
[5]郭晓倩,李艳,彭锐,等.心境障碍女性患者血浆白蛋白、总胆红素和尿酸心境障碍女性患者血浆白蛋白、总胆红素和尿酸水平研究水平研究[J].海南医学,2017,27(5):761-763.
[6]牟静,田聪聪,孙岩,等.双相情感障碍患者血清白介素水平的改变[J].国际精神病学杂志,2018,45(3):430-431.
[7]中华医学会神经病学分会神经心理学与行为神经病学组,中华医学会神经病学分会帕金森病及运动障碍学组.帕金森病抑郁、焦虑及精神病性障碍的诊断标准及治疗指南[J].中华神经科杂志,2013,46(1):56-60.
[8]李则挚,汪作为,禹顺英,等.双相障碍与脑源性神经营养因子外周血mRNA和蛋白表达相关性的研究[J].中华精神科杂志,2012,45(4):213-217.
[9]黄悦琦,邱美慧,高晨阳,等.抑郁症与双相抑郁患者脑白质微结构标志物探索[J].中华精神科杂志,2017,50(2):101-106.
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