依达拉奉联合鼠神经生长因子治疗老年高血压脑出血的临床效果及对血清NSE、IL-6、IL-8、hs-CRP的影响分析

详细信息    查看全文 | 推荐本文 |

英文篇名：Effect of Edaravone Combined with Mouse Nerve Growth Factor on Senile Hypertensive Cerebral Hemorrhage and Its Effect on Serum NSE, IL-6, IL-8 and hs-CRP 作者：陈勇 ; 陈琳 ; 徐冬 ; 张莹 ; 文业 ; 王定淼 ; 程乾 英文作者：CHEN Yong;CHEN Lin;XU Dong;ZHANG Ying;WEN Ye;WANG Dingmiao;CHENG Qian;Department of Critical Care Medicine,the First Affiliated Hospital of Hubei Academy of Science and Technology; 关键词：老年高血压脑出血 ; 依达拉奉 ; 鼠神经生长因子 ; 临床效果 ; 神经功能 ; 炎症因子 英文关键词：Senile hypertensive cerebral hemorrhage;;Edaravone;;Mouse nerve growth factor;;Clinical efficacy;;Neurological function;;Inflammatory factor 中文刊名：HNGY 英文刊名：Military Medical Journal of South China 机构：湖北科技学院附属第一医院重症医学科;湖北科技学院附属第一医院急诊科;武汉大学中南医院老年科; 出版日期：2019-03-28 出版单位：华南国防医学杂志 年：2019 期：v.33 基金：湖北省自然科学基金项目(2015CKC278) 语种：中文; 页：HNGY201903007 页数：4 CN：03 ISSN：42-1602/R 分类号：28-31

摘要

目的探讨依达拉奉联合鼠神经生长因子治疗老年高血压脑出血的临床效果及对血清神经元特异性烯醇化酶(neuron-specific enolase,NSE)、白细胞介素6(interleukin-6,IL-6)、白细胞介素8(interleukin-8,IL-8)、超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、血尿素氮(blood urea nitrogen,BUN)的影响。方法选取2014-10/2016-10月作者医院收治的老年高血压脑出血患者90例随机分为联合组和对照组,各45例。对照组在常规治疗基础上给予鼠神经生长因子进行治疗,联合组在对照组基础上加用依达拉奉注射液进行治疗。比较两组临床疗效、美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)评分、日常生活能力量表(activity of daily living scale,ADL)评分及血清NSE、IL-6、IL-8、hs-CRP、BUN水平。结果联合组总有效率、ADL评分显著高于对照组(P均<0.05),联合组NIHSS评分,血清NSE、IL-6、IL-8、hs-CRP水平显著低于对照组(P均<0.05)。联合组与对照组BUN值升高情况比较差异无统计学意义(P>0.05)。结论依达拉奉联合鼠神经生长因子治疗老年高血压脑出血临床效果显著,有效改善了患者神经功能缺损情况及血清NSE、IL-6、IL-8、hs-CRP水平,提高患者生活质量。
        Objective To investigate the clinical effect of edaravone combined with mouse nerve growth factor on senile hypertensive cerebral hemorrhage and its effect on serum neuron-specific enolase(NSE),interleukin 6(IL-6),interleukin 8(IL-8),high-sensitivity C-reactive protein(hs-CRP) and blood urea nitrogen(BUN).Methods A total of 90 elderly patients with hypertensive cerebral hemorrhage treated in authors′ hospital from October 2014 to October 2016 were randomly divided into combination group and control group,each group with 45 cases. The control group received mouse nerve growth factor therapy based on the routine treatment.The combination group received edaravone injection on the basis of the therapy of control group.The clinical efficacy, the national institute of health stroke scale(NIHSS) scores, daily living ability scale(ADL) scores and serum NSE, IL-6, IL-8, hs-CRP, BUN levels in two groups were compared.Results The total effective rate,ADL scores of combination group were significantly higher than those of control group(all P<0.05). The NIHSS score,the serum levels of NSE,IL-6,IL-8 and hs-CRP of combination group were significantly lower than those of control group(all P<0.05).There was no significant difference in BUN increase rate between two groups(P>0.05).Conclusion Edaravone combined with mouse nerve growth factor therapy can improve the clinical effect of senile hypertensive cerebral hemorrhage,effectively improve the neurological function and serum NSE, IL-6,IL-8 and hs-CRP levels of patients,and improve the quality of life of patients.

引文

[1] Nie Q, Guo P, Ge J, et al. Cerebral venous sinus thrombosis with cerebral hemorrhage during early pregnancy[J]. Neurosciences (Riyadh),2015,20(1):48-51
    [2] Ding R, Lin C, Wei S,et al. Therapeutic benefits of mesenchymal stromal cells in a rat model of hemoglobin-induced hypertensive intracerebral hemorrhage[J]. Mol Cells,2017,40(2):133-142
    [3] 王春生,李靖年,毕秋玲.鼠神经生长因子及甲基泼尼松龙鞘膜内应用治疗周围神经损伤[J].中国矫形外科杂志,2016,24(12):1113-1117
    [4] 吴强,衣学伟,张永梅.依达拉奉联合阿加曲班治疗急性脑梗死的疗效及对炎症因子与神经功能的影响[J].中国地方病防治杂志,2016,31(11):1294,1303
    [5] 王新德. 各类脑血管疾病诊断要点[J]. 中华神经科杂志, 1996,29(6):379-383
    [6] Tejada Meza H, MartínezGarcía R, CapabloLiesa JL, et al. Anticipating disaster: Mechanical thrombectomy in patients with low NIHSS scores[J]. Neurologia, 2017, 213(17): 30243-30248
    [7] 赵华,龚道恺.阿司匹林片联合阿托伐他汀钙片治疗急性脑梗死的临床研究[J].中国临床药理学杂志,2016,32(21):1934-1936,1941
    [8] Majidi S, Suarez JI, Qureshi AI. Management of Acute Hypertensive Response in Intracerebral Hemorrhage Patients After ATACH-2 Trial[J]. Neurocrit Care,2017,27(2):249-258
    [9] 张建荣,李燕,张金秀,等.延续性护理在高血压脑出血患者中的实施及对生活能力的影响[J].国际神经病学神经外科学杂志,2015, 42(1):37-40
    [10] 李延萍,景蓉,李水清,等.早期肢体康复训练对高血压脑出血偏瘫患者神经功能恢复的影响[J].中西医结合心脑血管病杂志,2015,13(6):844-846
    [11] 杨玉玲,木冬妹,高岭燕,等.鼠神经生长因子联合神经节苷酯对婴儿脑损伤后神经功能修复影响的临床研究[J].中国临床药理学杂志,2016,32(14):1265-1267
    [12] Wang HM, Zhang T, Huang JK, et al. Edaravone Attenuates the Proinflammatory Response in Amyloid-β-Treated Microglia by Inhibiting NLRP3 InflammasomeMediated IL-1β Secretion[J]. Cell Physiol Biochem, 2017,43(3):1113-1125
    [13] 段志辉,曹友林.鼠神经生长因子联合依达拉奉用于治疗脑出血的临床效果及对神经功能的影响[J].中国临床医生杂志,2016,44(4):44-47
    [14] 王佳,张红玉.不同程度颅脑损伤后炎症因子的表达及其临床意义[J].中国现代医学杂志,2016,26(3):72-75
    [15] 王超, 游潮, 刘窗溪,等. 高血压脑出血后血浆及脑脊液IL-1β和IL-6在病情评估中的应用价值[J]. 中华神经外科杂志, 2015, 31(11):1158-1160
    [16] 吴瑞,董治燕,李海军.鼠神经生长因子联合依达拉奉治疗脑出血的临床效果及对神经功能的影响[J].中国医药导报,2017,14(5):145-148
    [17] 何建平,王小艳,梁志乐.缺血性脑卒中血清神经元特异性烯醇化酶的变化及其意义[J].实用医学杂志,2017, 33(4):612-615