祛湿类单味中药对尿酸代谢的研究
|
摘要
通过查阅文献对具有降尿酸作用的单味中药进行研究发现,对比其他类单味中药,祛湿类单味中药降尿酸的文献报道居多,那么祛湿类单味中药与尿酸之间有何联系?是如何发挥降尿酸作用?该研究以2015年版《中国药典》、新世纪全国高等中医院校创新教材《临床中药学》中祛湿类中药为研究对象,通过中国知网(CNKI)、万方、维普等对祛湿类单味中药治疗高尿酸血症的文章进行检索。后采用Excel(2016)建立数据库,应用Excel筛选工具提取其降尿酸作用、药效部位、降尿酸途径及作用机制等分类统计,以明确祛湿类单味中药与尿酸之间的联系及其降尿酸的作用机制。整理结果显示:祛湿类的67味单味中药中,有降尿酸作用的中药共有16种,占所研究中药的23.88%;其他发挥降尿酸作用的有中药提取物和化学成分等;其降尿酸的途径主要为:抑制尿酸合成和促进尿酸排泄;作用机制多为调节尿酸生成的2个关键酶及尿酸排泄的离子转运蛋白。由此可见此类中药降尿酸作用明确,为治疗高尿酸血症的药物筛选、组方配伍和靶点确定,提供了新思路,为高尿酸血症的临床治疗和研究提供了理论依据。
Through literature review, it was found that there were many literature reports on the effect of single-herb traditional Chinese medicine for lowering uric acid in comparison with other single-herb traditional Chinese medicines. Then what is the relationship between single-herb traditional Chinese medicines for eliminating dampness and uric acid? How do they play a role in lowering uric acid? In this study, traditional Chinese medicines for eliminating dampness in the 2015 Chinese Pharmacopoeia and the innovative textbook of Clinical Chinese Pharmacy for Chinese medicine colleges and universities in the new century were selected as the research objects, and articles about the effect of single-herb traditional Chinese medicines for eliminating dampness in the treatment of hyperuricemia were searched through CNKI, WanFang and VIP. Afterwards, Excel(2016) was used to establish a database, and Excel screening tool was used to extract the classification statistics of its uric acid lowering effect, pharmacodynamic sites, uric acid lowering pathway and mechanism, so as to clarify the relationship between single-herb traditional Chinese medicines for eliminating dampness and uric acid as well as their mechanism on lowering uric acid. The results showed that there were 16 kinds of traditional Chinese medicines with uric acid lowering effect, accounting for 23.88% of the 67 kinds of traditional Chinese medicines for eliminating dampness. Other medicines with the uric acid lowering effect included traditional Chinese medicine extracts and chemical components. The main ways of reducing uric acid included: inhibiting uric acid synthesis and promoting uric acid excretion; mechanism of action was mainly regulating the two key enzymes generated by uric acid and the ion transporters excreted by uric acid. Therefore, it can be seen that this kind of traditional Chinese medicines have a clear effect in reducing uric acid, providing new ideas for drug screening, prescription compatibility and target determination for the treatment of hyperuricemia as well as a theoretical basis for the clinical treatment and research of hyperuricemia.
Through literature review, it was found that there were many literature reports on the effect of single-herb traditional Chinese medicine for lowering uric acid in comparison with other single-herb traditional Chinese medicines. Then what is the relationship between single-herb traditional Chinese medicines for eliminating dampness and uric acid? How do they play a role in lowering uric acid? In this study, traditional Chinese medicines for eliminating dampness in the 2015 Chinese Pharmacopoeia and the innovative textbook of Clinical Chinese Pharmacy for Chinese medicine colleges and universities in the new century were selected as the research objects, and articles about the effect of single-herb traditional Chinese medicines for eliminating dampness in the treatment of hyperuricemia were searched through CNKI, WanFang and VIP. Afterwards, Excel(2016) was used to establish a database, and Excel screening tool was used to extract the classification statistics of its uric acid lowering effect, pharmacodynamic sites, uric acid lowering pathway and mechanism, so as to clarify the relationship between single-herb traditional Chinese medicines for eliminating dampness and uric acid as well as their mechanism on lowering uric acid. The results showed that there were 16 kinds of traditional Chinese medicines with uric acid lowering effect, accounting for 23.88% of the 67 kinds of traditional Chinese medicines for eliminating dampness. Other medicines with the uric acid lowering effect included traditional Chinese medicine extracts and chemical components. The main ways of reducing uric acid included: inhibiting uric acid synthesis and promoting uric acid excretion; mechanism of action was mainly regulating the two key enzymes generated by uric acid and the ion transporters excreted by uric acid. Therefore, it can be seen that this kind of traditional Chinese medicines have a clear effect in reducing uric acid, providing new ideas for drug screening, prescription compatibility and target determination for the treatment of hyperuricemia as well as a theoretical basis for the clinical treatment and research of hyperuricemia.
引文
[1] 杨保林,丁岗.高尿酸血症中医论治己见[J].中国中医药现代远程教育,2010,8(9):20.
[2] 林凤平,任开明,宋恩峰,等.威灵仙对尿酸性肾病大鼠肾小管间质病变的保护作用[J].实用医学杂志,2006(1):18.
[3] 陆国寿,曾宪彪,王丽,等.蚕沙水提物对次黄嘌呤致急性高尿酸血症小鼠血尿酸含量的影响[J].中国医药指南,2012,10(17):94.
[4] 张柯媛,熊灏,曹斌,等.海风藤提取物灌胃对高尿酸血症小鼠血清尿酸水平影响及对痛风大鼠足跖肿胀的防治作用[J].山东医药,2017,57(27):37.
[5] 邢志博,王凤梅,王翠平,等.粉防己有效成分的药理活性研究进展[J].中国实验方剂学杂志,2014,20(9):241.
[6] 王彩萍. 桑枝提取物主要成分及其调节有机离子转运改善高尿酸血症机理研究[D].南京:南京大学,2010.
[7] 潘建强.雷公藤多甙治疗痛风性关节炎的临床观察[J].交通医学,1996(4):82.
[8] 杨政华. 雪莲外敷散治疗痛风性关节炎129例临床疗效观察[C]. 北京:中国骨伤发展战略高层论坛暨中西医结合骨伤学术大会,2004.
[9] Keiiehi S, Shinichi K, Yuji I,et al.Determination of atractylon in Atraetylodes rhizome using supercritieal fluid ehromatography 011-line coupled with supereritical fluid extraction by the direct induefion method [J].J Chromatogr A, 1998,810(1/2):252.
[10] 张双金,周燕,魏玉辉,等.茯苓水提物对高尿酸血症大鼠rURAT1 rOAT1和rOCT2表达的影响[J].西部医学,2016,28(12):1648.
[11] 冯时傧.加味四妙散对痛风血尿酸的影响及疗效观察[J].江西中医药,2002(3):22.
[12] 沈庆法.中医临床肾脏病学[M].上海:上海科学技术文献出版社,1997.
[13] 张俊平.中西医结合治疗痛风性关节炎[J].光明中医,2008(4):449.
[14] 郑璇,孙红.车前子对Wistar高尿酸大鼠降尿酸的机制研究[J].福建中医药,2010,41(6):52.
[15] 孙红,王少明,庄捷,等.土茯苓等中药抑制URAT1表达及降尿酸作用筛选研究[J].中国临床药理学与治疗学,2012,17(4):403.
[16] 兰友明,鲍雪娇,兰义明.滑石治疗痛风[J].中医杂志,2000(5):266.
[17] 李德和,余涛.三金三妙汤配合西药治疗痛风40例[J].陕西中医,2007(4):428.
[18] 唐柳.虎杖提取物对实验性痛风的作用及机理研究[D].西安:陕西中医学院,2007.
[19] 王晓梅,赵岩,赵卫星.痛风宁部分提取物对黄嘌呤氧化酶的抑制作用[J].安徽中医学院学报,2012,31(5):56.
[20] 张瑞. 光皮木瓜籽油的亚临界萃取及果肉黄酮降尿酸作用研究[D].武汉:武汉轻工大学,2016.
[21] 王晓梅,赵岩,刘丹,等.三种中药提取物对黄嘌呤氧化酶的抑制作用[J].氨基酸和生物资源,2013,35(1):57.
[22] 刘颖,郑立运,崔立然.秦艽抗大鼠高尿酸血症作用机制研究[J].中国医学创新,2013,10(22):143.
[23] 单海丽,单瑞平,傅旭春.穿山龙醇提取物对高尿酸血症小鼠的治疗作用[J].浙江大学学报:医学版,2015,44(1):49.
[24] 周琦,张翀,于栋华,等.穿山龙总皂苷对高尿酸血症的降尿酸及细胞抗炎作用研究[J].中华中医药杂志,2013,28(5):1444.
[25] 王建平,傅旭春,白海波.泽泻降血尿酸乙醇提取物的提取工艺研究[J].中国中药杂志,2010,35(14):1809.
[26] 汪锦飘,刘永茂,何志超,等.泽泻乙醇提取物对氧嗪酸钾盐致大鼠高尿酸血症模型的影响[J].中成药,2017,39(3):605.
[27] 于娟,王晓梅.薏苡仁和茯苓提取物对黄嘌呤氧化酶的抑制作用[J].中国药物与临床,2014,14(1):30.
[28] 姜彤伟,徐建,王晓明,等.玉米须中抑制黄嘌呤氧化酶活性组分的筛选及其作用[J].吉林大学学报:医学版,2011,37(3):433.
[29] 黎莉,戴立珍,杨靖,等.中药提取物中黄嘌呤氧化酶抑制剂的筛选[J].武汉工程大学学报,2010,32(3):44.
[30] 曾金祥,魏娟,毕莹,等.车前子醇提物降低急性高尿酸血症小鼠血尿酸水平及机制研究[J].中国实验方剂学杂志,2013,19(9):173.
[31] 曾金祥,许兵兵,王娟,等.车前子中毛蕊花糖苷及异毛蕊花糖苷降低急性高尿酸血症小鼠血尿酸水平及其机制[J].中成药,2016,38(7):1449.
[32] 陈光亮,朱立然,那莎,等.萆薢总皂苷对大鼠慢性高尿酸血症和肾小管尿酸转运体1表达的影响[J].中国中药杂志,2013,38(14):2348.
[33] 于舒雁.金钱草总黄酮对高尿酸血症动物模型的影响[D].郑州:河南中医学院,2014.
[34] Mandal A K,Mount D B.The molecular physiology of uric acid homeostasis [J].Anne Rev Physiol,2015,77(77): 323.
[35] Phippsgreen A J.Twenty-eight loci that influence serum urate levels: analysis of association with gout[J].Ann Rheum Dis,2016,75(1): 124.
[36] Kttgen A, Albrecht E, Teumer A,et al.Genome-wide association analyses identify 18 new loci associated with serum urate concentrations[J].Nat Genet, 2013, 45(2): 145.
[37] Ichida K,Matsuo H,Takada T,et al.Decreased extra-renal urate excretion is a common cause of hyperuricemia[J].Nat Commun,2012,3(3): 764.
[38] Sakurai H.Urate transporters in the genomic era[J].Curr Opin Nephrol Hypertens,2013,22(5): 545.
[39] 许洪波,周瑞,谢培,等.27种中草药的黄嘌呤氧化酶抑制活性筛选[J].时珍国医国药,2017,28(3):547.
[40] 史珅,张荣涛,尚小玉,等.葛根提取物对高尿酸血症大鼠血尿酸的影响[J].食品科技,2014,39 (2):216.
[41] 胡庆华,张宪,王钰,等.芒果苷促进高尿酸血症小鼠尿酸排泄和肾功能改善以及调节相关肾脏转运体的作用[J].药学学报,2010,45(10): 1239.
[42] 胡庆华,朱继孝,李宁,等.栀子苷对氧嗪酸钾盐致小鼠高尿酸血症的作用及其机制研究[J].中南药学,2013,11(10): 721.
[43] 周洁,孙超,李飞.中药活性成分降尿酸作用机制研究进展[J].中国药理学通报,2018,34(1):19.
[44] 姜萍.无症状高尿酸血症辨治思路探析[J].山东中医杂志,2014,33(8):632.
[45] 李松伟,王济华.王济华教授诊治痛风经验[J].风湿病与关节炎,2015,4(5): 42.
[46] 张冰,刘小青,丁正磊,等.鹌鹑高尿酸血症中医证候学研究[J].北京中医药大学学报,2006,29(10):676.
[47] 林志健,刘小青,张冰,等.基于指标量化的高尿酸血症鹌鹑模型中医证候分型研究[J].中华中医药杂志,2011,26(5):1072.
[48] 周盼,徐先祥,李沧海,等.中药干预尿酸转运体研究进展[J].中药药理与临床,2015,31(6):226.
[49] 陈鑫,黄兵,钟成家,等.高尿酸血症的中医分型及治疗方药研究[J].江西中医药,2013,44(5):38.
[50] 王进军,张荒生.治疗痛风经验[J].实用中医内科杂志,2006,20(1):23.
[51] 朱春胜,张冰,林志健,等.中医药治疗高尿酸血症的研究进展[J].中华中医药杂志,2015,30(12):4374.
[52] 周琦,刘树民.基于“尿酸转运体组”的中药治疗高尿酸血症的研究进展[J].中国中药杂志,2015,40(22):4346.
[53] 周珂,刘忠第,谭勇,等.高尿酸血症和非酒精性脂肪肝异病同治规律及分子机制预测[J]. 中国实验方剂学杂志, 2017,23(1):206.
[2] 林凤平,任开明,宋恩峰,等.威灵仙对尿酸性肾病大鼠肾小管间质病变的保护作用[J].实用医学杂志,2006(1):18.
[3] 陆国寿,曾宪彪,王丽,等.蚕沙水提物对次黄嘌呤致急性高尿酸血症小鼠血尿酸含量的影响[J].中国医药指南,2012,10(17):94.
[4] 张柯媛,熊灏,曹斌,等.海风藤提取物灌胃对高尿酸血症小鼠血清尿酸水平影响及对痛风大鼠足跖肿胀的防治作用[J].山东医药,2017,57(27):37.
[5] 邢志博,王凤梅,王翠平,等.粉防己有效成分的药理活性研究进展[J].中国实验方剂学杂志,2014,20(9):241.
[6] 王彩萍. 桑枝提取物主要成分及其调节有机离子转运改善高尿酸血症机理研究[D].南京:南京大学,2010.
[7] 潘建强.雷公藤多甙治疗痛风性关节炎的临床观察[J].交通医学,1996(4):82.
[8] 杨政华. 雪莲外敷散治疗痛风性关节炎129例临床疗效观察[C]. 北京:中国骨伤发展战略高层论坛暨中西医结合骨伤学术大会,2004.
[9] Keiiehi S, Shinichi K, Yuji I,et al.Determination of atractylon in Atraetylodes rhizome using supercritieal fluid ehromatography 011-line coupled with supereritical fluid extraction by the direct induefion method [J].J Chromatogr A, 1998,810(1/2):252.
[10] 张双金,周燕,魏玉辉,等.茯苓水提物对高尿酸血症大鼠rURAT1 rOAT1和rOCT2表达的影响[J].西部医学,2016,28(12):1648.
[11] 冯时傧.加味四妙散对痛风血尿酸的影响及疗效观察[J].江西中医药,2002(3):22.
[12] 沈庆法.中医临床肾脏病学[M].上海:上海科学技术文献出版社,1997.
[13] 张俊平.中西医结合治疗痛风性关节炎[J].光明中医,2008(4):449.
[14] 郑璇,孙红.车前子对Wistar高尿酸大鼠降尿酸的机制研究[J].福建中医药,2010,41(6):52.
[15] 孙红,王少明,庄捷,等.土茯苓等中药抑制URAT1表达及降尿酸作用筛选研究[J].中国临床药理学与治疗学,2012,17(4):403.
[16] 兰友明,鲍雪娇,兰义明.滑石治疗痛风[J].中医杂志,2000(5):266.
[17] 李德和,余涛.三金三妙汤配合西药治疗痛风40例[J].陕西中医,2007(4):428.
[18] 唐柳.虎杖提取物对实验性痛风的作用及机理研究[D].西安:陕西中医学院,2007.
[19] 王晓梅,赵岩,赵卫星.痛风宁部分提取物对黄嘌呤氧化酶的抑制作用[J].安徽中医学院学报,2012,31(5):56.
[20] 张瑞. 光皮木瓜籽油的亚临界萃取及果肉黄酮降尿酸作用研究[D].武汉:武汉轻工大学,2016.
[21] 王晓梅,赵岩,刘丹,等.三种中药提取物对黄嘌呤氧化酶的抑制作用[J].氨基酸和生物资源,2013,35(1):57.
[22] 刘颖,郑立运,崔立然.秦艽抗大鼠高尿酸血症作用机制研究[J].中国医学创新,2013,10(22):143.
[23] 单海丽,单瑞平,傅旭春.穿山龙醇提取物对高尿酸血症小鼠的治疗作用[J].浙江大学学报:医学版,2015,44(1):49.
[24] 周琦,张翀,于栋华,等.穿山龙总皂苷对高尿酸血症的降尿酸及细胞抗炎作用研究[J].中华中医药杂志,2013,28(5):1444.
[25] 王建平,傅旭春,白海波.泽泻降血尿酸乙醇提取物的提取工艺研究[J].中国中药杂志,2010,35(14):1809.
[26] 汪锦飘,刘永茂,何志超,等.泽泻乙醇提取物对氧嗪酸钾盐致大鼠高尿酸血症模型的影响[J].中成药,2017,39(3):605.
[27] 于娟,王晓梅.薏苡仁和茯苓提取物对黄嘌呤氧化酶的抑制作用[J].中国药物与临床,2014,14(1):30.
[28] 姜彤伟,徐建,王晓明,等.玉米须中抑制黄嘌呤氧化酶活性组分的筛选及其作用[J].吉林大学学报:医学版,2011,37(3):433.
[29] 黎莉,戴立珍,杨靖,等.中药提取物中黄嘌呤氧化酶抑制剂的筛选[J].武汉工程大学学报,2010,32(3):44.
[30] 曾金祥,魏娟,毕莹,等.车前子醇提物降低急性高尿酸血症小鼠血尿酸水平及机制研究[J].中国实验方剂学杂志,2013,19(9):173.
[31] 曾金祥,许兵兵,王娟,等.车前子中毛蕊花糖苷及异毛蕊花糖苷降低急性高尿酸血症小鼠血尿酸水平及其机制[J].中成药,2016,38(7):1449.
[32] 陈光亮,朱立然,那莎,等.萆薢总皂苷对大鼠慢性高尿酸血症和肾小管尿酸转运体1表达的影响[J].中国中药杂志,2013,38(14):2348.
[33] 于舒雁.金钱草总黄酮对高尿酸血症动物模型的影响[D].郑州:河南中医学院,2014.
[34] Mandal A K,Mount D B.The molecular physiology of uric acid homeostasis [J].Anne Rev Physiol,2015,77(77): 323.
[35] Phippsgreen A J.Twenty-eight loci that influence serum urate levels: analysis of association with gout[J].Ann Rheum Dis,2016,75(1): 124.
[36] Kttgen A, Albrecht E, Teumer A,et al.Genome-wide association analyses identify 18 new loci associated with serum urate concentrations[J].Nat Genet, 2013, 45(2): 145.
[37] Ichida K,Matsuo H,Takada T,et al.Decreased extra-renal urate excretion is a common cause of hyperuricemia[J].Nat Commun,2012,3(3): 764.
[38] Sakurai H.Urate transporters in the genomic era[J].Curr Opin Nephrol Hypertens,2013,22(5): 545.
[39] 许洪波,周瑞,谢培,等.27种中草药的黄嘌呤氧化酶抑制活性筛选[J].时珍国医国药,2017,28(3):547.
[40] 史珅,张荣涛,尚小玉,等.葛根提取物对高尿酸血症大鼠血尿酸的影响[J].食品科技,2014,39 (2):216.
[41] 胡庆华,张宪,王钰,等.芒果苷促进高尿酸血症小鼠尿酸排泄和肾功能改善以及调节相关肾脏转运体的作用[J].药学学报,2010,45(10): 1239.
[42] 胡庆华,朱继孝,李宁,等.栀子苷对氧嗪酸钾盐致小鼠高尿酸血症的作用及其机制研究[J].中南药学,2013,11(10): 721.
[43] 周洁,孙超,李飞.中药活性成分降尿酸作用机制研究进展[J].中国药理学通报,2018,34(1):19.
[44] 姜萍.无症状高尿酸血症辨治思路探析[J].山东中医杂志,2014,33(8):632.
[45] 李松伟,王济华.王济华教授诊治痛风经验[J].风湿病与关节炎,2015,4(5): 42.
[46] 张冰,刘小青,丁正磊,等.鹌鹑高尿酸血症中医证候学研究[J].北京中医药大学学报,2006,29(10):676.
[47] 林志健,刘小青,张冰,等.基于指标量化的高尿酸血症鹌鹑模型中医证候分型研究[J].中华中医药杂志,2011,26(5):1072.
[48] 周盼,徐先祥,李沧海,等.中药干预尿酸转运体研究进展[J].中药药理与临床,2015,31(6):226.
[49] 陈鑫,黄兵,钟成家,等.高尿酸血症的中医分型及治疗方药研究[J].江西中医药,2013,44(5):38.
[50] 王进军,张荒生.治疗痛风经验[J].实用中医内科杂志,2006,20(1):23.
[51] 朱春胜,张冰,林志健,等.中医药治疗高尿酸血症的研究进展[J].中华中医药杂志,2015,30(12):4374.
[52] 周琦,刘树民.基于“尿酸转运体组”的中药治疗高尿酸血症的研究进展[J].中国中药杂志,2015,40(22):4346.
[53] 周珂,刘忠第,谭勇,等.高尿酸血症和非酒精性脂肪肝异病同治规律及分子机制预测[J]. 中国实验方剂学杂志, 2017,23(1):206.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |