三七血伤宁胶囊对乳腺癌患者术后引流量及引流液中IL-8、TNF-α含量的影响
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摘要
目的观察三七血伤宁胶囊对乳腺癌改良根治术术后患者创伤反应及临床愈合作用的影响。方法41例乳腺癌改良根治术术后患者随机分为两组,对照组26例采用常规治疗,治疗组15例在对照组基础上术后6 h后加服三七血伤宁胶囊,每次0. 4 g,每日3次。于术后第12、24、36、48 h检测引流液中炎症因子肿瘤坏死因子α(TNF-α)以及白细胞介素8 (IL-8)的含量;记录术后第1～4天每日引流量及创面愈合情况。结果治疗组术后第3天、第4天引流量少于对照组(P <0. 05)。治疗组术区引流液中IL-8含量在术后36 h及术后48 h小于对照组(P <0. 05),两组均在术后36 h达峰值。治疗组术后伤口引流液体中TNF-α含量,术后36 h及术后48 h明显小于对照组(P <0. 01),两组均在术后24 h达到峰值。结论三七血伤宁胶囊能减轻乳腺癌改良根治术后创伤应激反应,减少引流液中IL-8及TNF-α含量,从而减少术后伤口引流量。
Objective To observe the effects of Sanqi Xueshangning Capsule(三七血伤宁胶囊) on traumatic response and clinical healing of patients treated with modified radical mastectomy. Methods Forty-one patients treated with modified radical mastectomy were randomly divided into 2 groups. Among them,26 cases in the control group were treated with conventional therapy,and 15 cases in the treatment group were additionally given Sanqi Xueshangning Capsule 6 h after operation,0. 4 g each time,3 times a day. The levels of inflammatory factors tumor necrosis factor-α(TNF-α) and interleukin-8(IL-8) in the drainage fluid were measured at 12 h,24 h,36 h,and 48 h post-operatively; the daily drainage volume and wound healing were recorded from 1 st to 4 th day after surgery. Results The drainage volumes of the treatment group on the 3 rd and 4 th day after operation was lower than those in the control group(P < 0. 05). The IL-8 contents in the drainage fluid of the treatment group was lower than those of the control group at 36 h and 48 h after operation(P < 0. 05). Both groups peaked at 36 h after operation. The TNF-αlevels in the fluid of the treatment group was significantly lower than those of the control group at 36 h and 48 h after operation(P < 0. 01). Both groups peaked at 24 h after operation. Conclusion Sanqi Xueshangning Capsule can alleviate the traumatic stress response after modified radical mastectomy and reduce the levels of IL-8 and TNF-α in the drainage fluid,thus reducing the post-operative wound drainage.
Objective To observe the effects of Sanqi Xueshangning Capsule(三七血伤宁胶囊) on traumatic response and clinical healing of patients treated with modified radical mastectomy. Methods Forty-one patients treated with modified radical mastectomy were randomly divided into 2 groups. Among them,26 cases in the control group were treated with conventional therapy,and 15 cases in the treatment group were additionally given Sanqi Xueshangning Capsule 6 h after operation,0. 4 g each time,3 times a day. The levels of inflammatory factors tumor necrosis factor-α(TNF-α) and interleukin-8(IL-8) in the drainage fluid were measured at 12 h,24 h,36 h,and 48 h post-operatively; the daily drainage volume and wound healing were recorded from 1 st to 4 th day after surgery. Results The drainage volumes of the treatment group on the 3 rd and 4 th day after operation was lower than those in the control group(P < 0. 05). The IL-8 contents in the drainage fluid of the treatment group was lower than those of the control group at 36 h and 48 h after operation(P < 0. 05). Both groups peaked at 36 h after operation. The TNF-αlevels in the fluid of the treatment group was significantly lower than those of the control group at 36 h and 48 h after operation(P < 0. 01). Both groups peaked at 24 h after operation. Conclusion Sanqi Xueshangning Capsule can alleviate the traumatic stress response after modified radical mastectomy and reduce the levels of IL-8 and TNF-α in the drainage fluid,thus reducing the post-operative wound drainage.
引文
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[24]殷捷鸿.中药三七抗衰老作用研究进展[J].中国老年学,2016,36(12):3060-3061.
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[26]SINN DI,LEE ST,CHU K,et al. Proteasomal inhibition in intracerebral hemorrhage:neuroprotective and anti-inflammatory effects of bortezomib[J]. NEUROSCI RES,2007,58(1):12-18.
[27]苗雪,官杰. IL-8的研究进展[J].齐齐哈尔医学院学报,2011,32(22):3693-3695.
[2]师金,梁迪,李道娟,等.全球女性乳腺癌流行情况研究[J].中国肿瘤,2017,26(9):683-690.
[3]LAKHANI SR,ELLIS IO,SCHNITT SJ,et al. WHO classifcation of tumours of the breast[M]. Lyon:IARC Press,2012:108-112.
[4]乐海浪,罗国强.创伤后早期炎症因子TNF-α、IL-1、IL-6的研究进展[J].现代诊断与治疗,2014,25(4):763-765.
[5]庄心良,曾因明,陈伯銮.现代麻醉学[M]. 3版.北京:人民卫生出版社,2008:167.
[6]沈颖洁,刘喆.手术创伤应激与炎性细胞因子的相关研究进展[J].辽宁中医药大学学报,2011,13(11):75-77.
[7]高学敏,肖艳萍.三七血伤宁胶囊的药理分析[J].首都医药,2004,11(4):51.
[8]孙凤志,孙明江,吕旭潇.中药三七止血活血作用的研究进展[J].医学研究杂志,2013,42(9):24-26.
[9]DORTG TX,CUI XM,SONG ZH,et al. Chemical assessment of roots of panax notoginseng in China:regional and seasonal variations in its active constituents[J]. J AGR FOOD CHEM,2003,51(16):4617-4623.
[10]贾彩玲.麦默通微创旋切术术中灌注三七总皂苷预防术后血肿及皮肤瘀斑的临床研究[D].南宁:广西中医药大学,2016:1-31.
[11]李铁,贾彩玲,卓睿.乳腺微创旋切术中灌注三七总皂苷预防术后乳腺血肿及皮肤瘀斑的临床研究[J].广西医学,2017,39(3):345-346.
[12]LI CT,WANG HB,XU BJ. A comparative study on anticoagulant activities of three Chinese herbal medicines from the genus panax and anticoagulant activities of ginsenosides Rg1 and Rg2[J]. PHARM BIO,2013,51(8):1077-1080.
[13]于德伟,陈文学,杨铭,等.三七活血片对大鼠急性软组织损伤治疗作用的实验研究[J].中国中医药科技,2016,23(1):28-29.
[14]ZHANG E,GAO B,YANG L,et al. Notoginsenoside Ft1 Promotes Fibroblast Proliferation via PI3K/Akt/m TOR Signaling Pathway and Benefits Wound Healing in Genetically Diabetic Mice[J]. J PHARMACOL EXP THER,2016,356(2):324-332.
[15]YU L,XIE J,XIN N,et al. Panax notoginseng saponins promote wound repair of anterior cruciate ligament through phosphorylation of PI3K,AKT and ERK[J]. Int J Clin Exp Pathol,2015,8(1):441-449.
[16]QIANG H,LIU H,LING M,et al. Early Steroid-Induced Osteonecrosis of Rabbit Femoral Head and Panax notoginseng Saponins:Mechanism and Protective Effects[J]. EVID-BASED COMEPL ALT,2015,(2015-3-16),2015,14(1):1-10.
[17]YEH CH,LIN Y M,WU YC,et al. Inhibition of NFkappa B activation can attenuate ischemia/reperfusion-induced contractility impairment via decreasing cardiomyocytic proinflammatory gene up-regulation and matrix metalloproteinase expression[J]. J Cardiovasc Pharmacol,2005,45(4):301-309.
[18]潘少霞.三七总皂苷对缺氧再给氧血管内皮细胞损伤保护效果研究[J].中国医学工程,2012,20(7):98.
[19]HUANG XP,DING H,LU JD,et al. Effects of the Combination of the main active components of astragalus and panax notoginseng on inflammation and apoptosis of nerve cell after cerebral ischemia-reperfusion[J]. AM J CHINESE MED,2015,43(7):1419-1438.
[20]ZHOU N,YANG T,KEEP RF,et al. Antioxidative effects of Panax notoginseng saponin in brain cells[J].Phytomedicine,2014,21(10):1189-1195.
[21]LIU F,BAI X,DING RB,et al. UPLC/Q-TOFMSbased metabolomics studies on the protective effect of panax notoginseng saponins on alcoholic liver injury[J].AM J CHINESE MED,2015,43(4):1550043-1550063.
[22]XIAN-SI Z,JIN-JING J,LI-FANG M. Gensenoside Rb1protects rat PC12 cells from oxidative stress-induced endoplasmic reticulum stress:the involvement of thioredoxin-1[J]. MOL CELL BIOCHEM,2015,410(2):239-246.
[23]HUANG J L,JING X,TIAN X,et al. Neuroprotective properties of panax notoginseng saponins via preventing oxidative stress injury in SAMP8 mice[J]. Evid Based Complement Alternat Med,2017,14(4):1-7.
[24]殷捷鸿.中药三七抗衰老作用研究进展[J].中国老年学,2016,36(12):3060-3061.
[25]WANG MM,XUE M,XU YG,et al. Panax notoginseng saponin is superior to aspirin in inhibiting platelet adhesion to injured endothelial cells through COX pathway in vitro[J]. THROMB RES,2016,141(5):146-152.
[26]SINN DI,LEE ST,CHU K,et al. Proteasomal inhibition in intracerebral hemorrhage:neuroprotective and anti-inflammatory effects of bortezomib[J]. NEUROSCI RES,2007,58(1):12-18.
[27]苗雪,官杰. IL-8的研究进展[J].齐齐哈尔医学院学报,2011,32(22):3693-3695.
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