静磁场与活性氧
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摘要
活性氧(reactive oxygen species, ROS)普遍存在于动植物中,参与多个信号通路,其水平依赖于产生和清除过程的动态平衡。目前有多项研究发现,静磁场能够影响细胞内ROS水平,但其结果并不一致。本文系统分析和比较了不同参数静磁场(也称稳态磁场)对多种生物样本ROS水平的影响,发现静磁场对生物体内ROS影响的不一致性与磁场处理本身(包括磁场强度、方向、处理时间等)和研究对象(包括细胞类型和状态等)都有关系,并且还取决于所检测的ROS类型(过氧化氢、超氧阴离子和羟自由基等)。分析和总结现有的静磁场对ROS的影响不仅有助于我们深入了解静磁场的生物学效应,为下一步机制研究提供实验依据,并且为开发静磁场在生物医学中的潜在应用提供一定的理论基础。
Reactive oxygen species(ROS) ubiquitously exist in animal and plant cells, participate in various signaling pathways, and their levels are determined by the dynamic balance between generation and scavenging.Previous studies have found that static magnetic field(SMF) could affect cellular ROS levels in a variable way. In this review, we systemically analyzed and compared the influence of different SMFs on ROS levels in different biological samples and found that the inconsistency might arise not only from SMF itself, including SMF intensity, direction and exposure time, but also the samples examined, such as cell type, adherent condition,as well as the specific ROS types(hydrogen peroxide, superoxide anion and hydroxyl radical). This will not only help us understand the biological effects of SMF in depth, providing the experimental evidences for further mechanistic studies, but also could provide theoretical basis for potential biomedical applications of SMF in the future.
Reactive oxygen species(ROS) ubiquitously exist in animal and plant cells, participate in various signaling pathways, and their levels are determined by the dynamic balance between generation and scavenging.Previous studies have found that static magnetic field(SMF) could affect cellular ROS levels in a variable way. In this review, we systemically analyzed and compared the influence of different SMFs on ROS levels in different biological samples and found that the inconsistency might arise not only from SMF itself, including SMF intensity, direction and exposure time, but also the samples examined, such as cell type, adherent condition,as well as the specific ROS types(hydrogen peroxide, superoxide anion and hydroxyl radical). This will not only help us understand the biological effects of SMF in depth, providing the experimental evidences for further mechanistic studies, but also could provide theoretical basis for potential biomedical applications of SMF in the future.
引文
[1]Trachootham D,Alexandre J,Huang P.Targeting cancer cells by ROS-mediated mechanisms:a radical therapeutic approach?Nat Rev Drug Discov,2009,8(7):579-591
[2]Liou GY,Storz P.Reactive oxygen species in cancer.Free Radic Res,2010,44(5):479-496
[3]Sabharwal SS,Schumacker PT.Mitochondrial ROS in cancer:initiators,amplifiers or an Achilles'heel?Nat Rev Cancer,2014,14(11):709-721
[4]Schumacker PT.Reactive oxygen species in cancer cells:live by the sword,die by the sword.Cancer Cell,2006,10(3):175-176
[5]Pelicano H,Carney D,Huang P.ROS stress in cancer cells and therapeutic implications.Drug Resist Updat,2004,7(2):97-110
[6]Wang J,Yi J.Cancer cell killing via ROS:to increase or decrease,that is the question.Cancer Biol Ther,2008,7(12):1875-1884
[7]Martindale JL,Holbrook NJ.Cellular response to oxidative stress:signaling for suicide and survival.J Cell Physiol,2002,192(1):1-15
[8]Zhang X,Yarema K,Xu A.Biological Effects of Static Magnetic Fields[M].Springer,2017.ISBN:978-981-10-3579-1
[9]张欣,Yarema K,许安.稳态磁场的生物学效应[M].张磊,刘娟娟译.北京:科学出版社,2018.ISBN:978-703-056598-3
[10]Wang H,Zhang X.Magnetic fields and reactive oxygen species.Int J Mol Sci,2017,18(10):2175
[11]Calabro E,Condello S,Curro M,et al.Effects of low intensity static magnetic field on FTIR spectra and ROSproduction in SH-SY5Y neuronal-like cells.Bioelectromagnetics,2013,34(8):618-629
[12]陈文芳.磁场对不同细胞的生物效应与磁场增强抗癌药物杀伤不同肿瘤细胞的机制初探[D].西安:陕西师范大学,2010
[13]程婕,徐巧玲,申广浩,等.恒磁场对阿霉素杀伤人乳腺癌细胞的协同作用.第四军医大学学报,2009,30(24):3006-3008
[14]Kamalipooya S,Abdolmaleki P,Salemi Z,et al.Simultaneous application of cisplatin and static magnetic field enhances oxidative stress in HeLa cell line.In Vitro Cell Dev Biol Anim,2017,53(9):783-790
[15]Hajipour Verdom B,Abdolmaleki P,Behmanesh M.The static magnetic field remotely boosts the efficiency of doxorubicin through modulating ROS behaviors.Sci Rep,2018,8(1):990
[16]Bekhite MM,Finkensieper A,Abou-Zaid FA,et al.Static electromagnetic fields induce vasculogenesis and chondroosteogenesis of mouse embryonic stem cells by reactive oxygen species-mediated up-regulation of vascular endothelial growth factor.Stem Cells Dev,2010,19(5):731-743
[17]Bekhite MM,Figulla HR,Sauer H,et al.Static magnetic fields increase cardiomyocyte differentiation of Flk-1+cells derived from mouse embryonic stem cells via Ca2+influx and ROS production.Int J Cardiol,2013,167(3):798-808
[18]Bae JE,Huh MI,Ryu BK,et al.The effect of static magnetic fields on the aggregation and cytotoxicity of magnetic nanoparticles.Biomaterials,2011,32(35):9401-9414
[19]Fu JP,Mo WC,Liu Y,et al.Decline of cell viability and mitochondrial activity in mouse skeletal muscle cell in a hypomagnetic field.Bioelectromagnetics,2016,37(4):212-222
[20]De Nicola M,Cordisco S,Cerella C,et al.Magnetic fields protect from apoptosis via redox alteration.Ann NY Acad Sci,2006,1090(1):59-68
[21]Poniedzialek B,Rzymski P,Karczewski J,et al.Reactive oxygen species(ROS)production in human peripheral blood neutrophils exposed in vitro to static magnetic field.Electromagn Biol Med,2013,32(4):560-568
[22]Sullivan K,Balin AK and Allen RG.Effects of static magnetic fields on the growth of various types of human cells.Bioelectromagnetics,2011,32(2):140-147
[23]Zablotskii V,Syrovets T,Schmidt ZW,et al.Modulation of monocytic leukemia cell function and survival by high gradient magnetic fields and mathematical modeling studies.Biomaterials,2014,35(10):3164-3171
[24]杜鹃.恒强磁场对肿瘤细胞线粒体机能的影响[D].沈阳:沈阳工业大学,2014
[25]Zhao G,Chen S,Wang L,et al.Cellular ATP content was decreased by a homogeneous 8.5 T static magnetic field exposure:role of reactive oxygen species.Bioelectromagnetics,2011,32(2):94-101
[26]丁冲.稳恒磁场对细胞电磁特性和生物学效应的影响[D].西安:西北工业大学,2014
[27]Politanski P,Rajkowska E,Brodecki M,et al.Combined effect of X-ray radiation and static magnetic fields on reactive oxygen species in rat lymphocytes in vitro.Bioelectromagnetics,2013,34(4):333-336
[28]Marycz K,Maredziak M,Lewandowski D,et al.The Effect of Co0.2Mn0.8Fe2O4 ferrite nanoparticles on the C2 canine mastocytoma cell line and adipose-derived mesenchymal stromal stem cells(ASCs)cultured under a static magnetic field:possible implications in the treatment of dog mastocytoma.Cell Mol Bioeng,2017,10(3):209-222
[29]Csillag A,Kumar BV,Szabo K,et al.Exposure to inhomogeneous static magnetic field beneficially affects allergic inflammation in a murine model.J R Soc Interface,2014,11(95):20140097
[30]Van Huizen AV,Morton JM,Kinsey LJ,et al.Weak magnetic fields alter stem cell-mediated growth.Sci Adv,2019,5(1):eaau7201
[31]Wang HZ,Zhang X.ROS reduction does not decrease the anticancer efficacy of X-ray in two breast cancer cell lines.2019,https://doi.org/10.1155/2019/3782074
[32]Zhang HT,Zhang ZJ,Mo WC,et al.Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase.Protein Cell,2017,8(7):527-537
[33]Romeo S,Sannino A,Scarfi MR,et al.Lack of effects on key cellular parameters of MRC-5 human lung fibroblasts exposed to 370 mT static magnetic field.Sci Rep,2016,6:19398
[34]Bajpai I,Balani K and Basu B.Synergistic effect of static magnetic field and HA-Fe3O4 magnetic composites on viability of S.aureus and E.coli bacteria.J Biomed Mater Res B Appl Biomater,2014,102(3):524-532
[35]Bhardwaj J,Anand A,Nagarajan S.Biochemical and biophysical changes associated with magnetopriming in germinating cucumber seeds.Plant Physiol Biochem,2012,57:67-73
[36]Anand A,Nagarajan S,Verma AP,et al.Pre-treatment of seeds with static magnetic field ameliorates soil water stress in seedlings of maize(Zea mays L.).Indian J Biochem Biophys,2012,49(1):63-70
[37]Haghighat N,Abdolmaleki P,Ghanati F,et al.Modification of catalase and MAPK in Vicia faba cultivated in soil with high natural radioactivity and treated with a static magnetic field.J Plant Physiol,2014,171(5):99-103
[38]Shine MB,Guruprasad KN,Anand A.Effect of stationary magnetic field strengths of 150 and 200 mT on reactive oxygen species production in soybean.Bioelectromagnetics,2012,33(5):428-437
[39]Martino CF,Castello PR.Modulation of hydrogen peroxide production in cellular systems by low level magnetic fields.PLoS One,2011,6(8):e22753
[40]Chen YP,Li R,He JM.Magnetic field can alleviate toxicological effect induced by cadmium in mungbean seedlings.Ecotoxicology,2011,20(4):760-769
[41]Cakmak T,Cakmak ZE,Dumlupinar R,et al.Analysis of apoplastic and symplastic antioxidant system in shallot leaves:impacts of weak static electric and magnetic field.J Plant Physiol,2012,169(11):1066-1073
[42]Vergallo C,Ahmadi M,Mobasheri H,et al.Impact of inhomogeneous static magnetic field(31.7-232.0 mT)exposure on human neuroblastoma SH-SY5Y cells during cisplatin administration.PLoS One,2014,9(11):e113530
[43]Roman A,Tombarkiewicz B.Prolonged weakening of the geomagnetic field(GMF)affects the immune system of rats.Bioelectromagnetics,2009,30(1):21-28
[44]Shine MB,Guruprasad KN.Impact of pre-sowing magnetic field exposure of seeds to stationary magnetic field on growth,reactive oxygen species and photosynthesis of maize under field conditions.Acta Physiologiae Plantarum,2012,34(1):255-265
[45]Baby SM,Narayanaswamy GK,Anand A.Superoxide radical production and performance index of Photosystem II in leaves from magnetoprimed soybean seeds.Plant Signal Behav,2011,6(11):1635-1637
[46]Chen YP,Chen D,Liu Q.Exposure to a magnetic field or laser radiation ameliorates effects of Pb and Cd on physiology and growth of young wheat seedlings.J Photochem Photobiol B,2017,169:171-177
[47]张雯,王绪绪,林华香,等.磁场对光催化反应羟基自由基生成速率的影响.化学学报,2005,63(18):1765-1768
[48]Poniedzialek B,Rzymski P,Nawrocka-Bogusz H,et al.The effect of electromagnetic field on reactive oxygen species production in human neutrophils in vitro.Electromagn Biol Med,2013,32(3):333-341
[49]Tian X,Wang D,Zha M,et al.Magnetic field direction differentially impacts the growth of different cell types.Electromagn Biol Med,2018,37(2):114-125
[50]Limoli CL,Rola R,Giedzinski E,et al.Cell-densitydependent regulation of neural precursor cell function.Proc Natl Acad Sci USA,2004,101(45):16052-16057
[2]Liou GY,Storz P.Reactive oxygen species in cancer.Free Radic Res,2010,44(5):479-496
[3]Sabharwal SS,Schumacker PT.Mitochondrial ROS in cancer:initiators,amplifiers or an Achilles'heel?Nat Rev Cancer,2014,14(11):709-721
[4]Schumacker PT.Reactive oxygen species in cancer cells:live by the sword,die by the sword.Cancer Cell,2006,10(3):175-176
[5]Pelicano H,Carney D,Huang P.ROS stress in cancer cells and therapeutic implications.Drug Resist Updat,2004,7(2):97-110
[6]Wang J,Yi J.Cancer cell killing via ROS:to increase or decrease,that is the question.Cancer Biol Ther,2008,7(12):1875-1884
[7]Martindale JL,Holbrook NJ.Cellular response to oxidative stress:signaling for suicide and survival.J Cell Physiol,2002,192(1):1-15
[8]Zhang X,Yarema K,Xu A.Biological Effects of Static Magnetic Fields[M].Springer,2017.ISBN:978-981-10-3579-1
[9]张欣,Yarema K,许安.稳态磁场的生物学效应[M].张磊,刘娟娟译.北京:科学出版社,2018.ISBN:978-703-056598-3
[10]Wang H,Zhang X.Magnetic fields and reactive oxygen species.Int J Mol Sci,2017,18(10):2175
[11]Calabro E,Condello S,Curro M,et al.Effects of low intensity static magnetic field on FTIR spectra and ROSproduction in SH-SY5Y neuronal-like cells.Bioelectromagnetics,2013,34(8):618-629
[12]陈文芳.磁场对不同细胞的生物效应与磁场增强抗癌药物杀伤不同肿瘤细胞的机制初探[D].西安:陕西师范大学,2010
[13]程婕,徐巧玲,申广浩,等.恒磁场对阿霉素杀伤人乳腺癌细胞的协同作用.第四军医大学学报,2009,30(24):3006-3008
[14]Kamalipooya S,Abdolmaleki P,Salemi Z,et al.Simultaneous application of cisplatin and static magnetic field enhances oxidative stress in HeLa cell line.In Vitro Cell Dev Biol Anim,2017,53(9):783-790
[15]Hajipour Verdom B,Abdolmaleki P,Behmanesh M.The static magnetic field remotely boosts the efficiency of doxorubicin through modulating ROS behaviors.Sci Rep,2018,8(1):990
[16]Bekhite MM,Finkensieper A,Abou-Zaid FA,et al.Static electromagnetic fields induce vasculogenesis and chondroosteogenesis of mouse embryonic stem cells by reactive oxygen species-mediated up-regulation of vascular endothelial growth factor.Stem Cells Dev,2010,19(5):731-743
[17]Bekhite MM,Figulla HR,Sauer H,et al.Static magnetic fields increase cardiomyocyte differentiation of Flk-1+cells derived from mouse embryonic stem cells via Ca2+influx and ROS production.Int J Cardiol,2013,167(3):798-808
[18]Bae JE,Huh MI,Ryu BK,et al.The effect of static magnetic fields on the aggregation and cytotoxicity of magnetic nanoparticles.Biomaterials,2011,32(35):9401-9414
[19]Fu JP,Mo WC,Liu Y,et al.Decline of cell viability and mitochondrial activity in mouse skeletal muscle cell in a hypomagnetic field.Bioelectromagnetics,2016,37(4):212-222
[20]De Nicola M,Cordisco S,Cerella C,et al.Magnetic fields protect from apoptosis via redox alteration.Ann NY Acad Sci,2006,1090(1):59-68
[21]Poniedzialek B,Rzymski P,Karczewski J,et al.Reactive oxygen species(ROS)production in human peripheral blood neutrophils exposed in vitro to static magnetic field.Electromagn Biol Med,2013,32(4):560-568
[22]Sullivan K,Balin AK and Allen RG.Effects of static magnetic fields on the growth of various types of human cells.Bioelectromagnetics,2011,32(2):140-147
[23]Zablotskii V,Syrovets T,Schmidt ZW,et al.Modulation of monocytic leukemia cell function and survival by high gradient magnetic fields and mathematical modeling studies.Biomaterials,2014,35(10):3164-3171
[24]杜鹃.恒强磁场对肿瘤细胞线粒体机能的影响[D].沈阳:沈阳工业大学,2014
[25]Zhao G,Chen S,Wang L,et al.Cellular ATP content was decreased by a homogeneous 8.5 T static magnetic field exposure:role of reactive oxygen species.Bioelectromagnetics,2011,32(2):94-101
[26]丁冲.稳恒磁场对细胞电磁特性和生物学效应的影响[D].西安:西北工业大学,2014
[27]Politanski P,Rajkowska E,Brodecki M,et al.Combined effect of X-ray radiation and static magnetic fields on reactive oxygen species in rat lymphocytes in vitro.Bioelectromagnetics,2013,34(4):333-336
[28]Marycz K,Maredziak M,Lewandowski D,et al.The Effect of Co0.2Mn0.8Fe2O4 ferrite nanoparticles on the C2 canine mastocytoma cell line and adipose-derived mesenchymal stromal stem cells(ASCs)cultured under a static magnetic field:possible implications in the treatment of dog mastocytoma.Cell Mol Bioeng,2017,10(3):209-222
[29]Csillag A,Kumar BV,Szabo K,et al.Exposure to inhomogeneous static magnetic field beneficially affects allergic inflammation in a murine model.J R Soc Interface,2014,11(95):20140097
[30]Van Huizen AV,Morton JM,Kinsey LJ,et al.Weak magnetic fields alter stem cell-mediated growth.Sci Adv,2019,5(1):eaau7201
[31]Wang HZ,Zhang X.ROS reduction does not decrease the anticancer efficacy of X-ray in two breast cancer cell lines.2019,https://doi.org/10.1155/2019/3782074
[32]Zhang HT,Zhang ZJ,Mo WC,et al.Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase.Protein Cell,2017,8(7):527-537
[33]Romeo S,Sannino A,Scarfi MR,et al.Lack of effects on key cellular parameters of MRC-5 human lung fibroblasts exposed to 370 mT static magnetic field.Sci Rep,2016,6:19398
[34]Bajpai I,Balani K and Basu B.Synergistic effect of static magnetic field and HA-Fe3O4 magnetic composites on viability of S.aureus and E.coli bacteria.J Biomed Mater Res B Appl Biomater,2014,102(3):524-532
[35]Bhardwaj J,Anand A,Nagarajan S.Biochemical and biophysical changes associated with magnetopriming in germinating cucumber seeds.Plant Physiol Biochem,2012,57:67-73
[36]Anand A,Nagarajan S,Verma AP,et al.Pre-treatment of seeds with static magnetic field ameliorates soil water stress in seedlings of maize(Zea mays L.).Indian J Biochem Biophys,2012,49(1):63-70
[37]Haghighat N,Abdolmaleki P,Ghanati F,et al.Modification of catalase and MAPK in Vicia faba cultivated in soil with high natural radioactivity and treated with a static magnetic field.J Plant Physiol,2014,171(5):99-103
[38]Shine MB,Guruprasad KN,Anand A.Effect of stationary magnetic field strengths of 150 and 200 mT on reactive oxygen species production in soybean.Bioelectromagnetics,2012,33(5):428-437
[39]Martino CF,Castello PR.Modulation of hydrogen peroxide production in cellular systems by low level magnetic fields.PLoS One,2011,6(8):e22753
[40]Chen YP,Li R,He JM.Magnetic field can alleviate toxicological effect induced by cadmium in mungbean seedlings.Ecotoxicology,2011,20(4):760-769
[41]Cakmak T,Cakmak ZE,Dumlupinar R,et al.Analysis of apoplastic and symplastic antioxidant system in shallot leaves:impacts of weak static electric and magnetic field.J Plant Physiol,2012,169(11):1066-1073
[42]Vergallo C,Ahmadi M,Mobasheri H,et al.Impact of inhomogeneous static magnetic field(31.7-232.0 mT)exposure on human neuroblastoma SH-SY5Y cells during cisplatin administration.PLoS One,2014,9(11):e113530
[43]Roman A,Tombarkiewicz B.Prolonged weakening of the geomagnetic field(GMF)affects the immune system of rats.Bioelectromagnetics,2009,30(1):21-28
[44]Shine MB,Guruprasad KN.Impact of pre-sowing magnetic field exposure of seeds to stationary magnetic field on growth,reactive oxygen species and photosynthesis of maize under field conditions.Acta Physiologiae Plantarum,2012,34(1):255-265
[45]Baby SM,Narayanaswamy GK,Anand A.Superoxide radical production and performance index of Photosystem II in leaves from magnetoprimed soybean seeds.Plant Signal Behav,2011,6(11):1635-1637
[46]Chen YP,Chen D,Liu Q.Exposure to a magnetic field or laser radiation ameliorates effects of Pb and Cd on physiology and growth of young wheat seedlings.J Photochem Photobiol B,2017,169:171-177
[47]张雯,王绪绪,林华香,等.磁场对光催化反应羟基自由基生成速率的影响.化学学报,2005,63(18):1765-1768
[48]Poniedzialek B,Rzymski P,Nawrocka-Bogusz H,et al.The effect of electromagnetic field on reactive oxygen species production in human neutrophils in vitro.Electromagn Biol Med,2013,32(3):333-341
[49]Tian X,Wang D,Zha M,et al.Magnetic field direction differentially impacts the growth of different cell types.Electromagn Biol Med,2018,37(2):114-125
[50]Limoli CL,Rola R,Giedzinski E,et al.Cell-densitydependent regulation of neural precursor cell function.Proc Natl Acad Sci USA,2004,101(45):16052-16057
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