180例稽留流产患者发病危险因素分析
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摘要
目的对180例稽留流产患者发病危险因素进行分析。方法选取2014年1月～2017年6月在我院就诊的稽留流产患者(180例)以及正常妊娠但自愿要求人工终止妊娠的孕妇(220例)作为研究对象。对两组孕妇的年龄、身高、体重、文化程度、怀孕史、生育史、生活环境、工作环境、生活习惯、宫腔内操作史、乙肝病毒携带、并发症、心理障碍、感染因素等进行单因素方差分析和多因素Logistic分析。结果 (1)单因素分析,两组之间年龄、身高、体重、文化程度、怀孕史等差异无统计学意义(P> 0.05);(2)单因素分析,两组之间工作环境、生活环境、生活习惯、宫腔内操作史、乙肝病毒携带等差异有统计学意义(P <0.05);(3)单因素分析,两组之间并发症、心理障碍、感染等差异有统计学意义(P <0.05);(4)多因素Logistic分析,两组之间在吸烟、饮酒、服药、宫腔内操作史、乙肝病毒携带、并发症、心理障碍和感染等方面差异有统计学意义(P <0.05)。结论临床医师应对该孕妇人群积极开展健康教育,养成良好的生活习惯,加强孕前检查宣传力度,以防止稽留流产的发生。
Objective To analyze the risk factors of 180 patients with missed abortion. Methods 180 patients with missed abortion who were treated in our hospital from January 2014 to June 2017 and 220 pregnant women who had normal pregnancy but volunteered to terminate the pregnancy(220 cases) were selected as research subjects. The age,height, weight, education level, pregnancy history, birth history, living environment, working environment, living habits, intrauterine operation history, hepatitis b virus infectivities, complications, psychological disorders,and infectious factors of pregnant womenin two groups were analyzed by single factor analysis of variance and multi-factor Logistics. Results(1) By single factor analysis, there was no statistically significant difference in age, height, weight, culture level and pregnancy history between the two groups(P > 0.05).(2) The single factor analysis showed that there were statistically significant differences between the two groups in working environment, living environment, living habits, intrauterine operation history and hepatitis b virus infectivities(P < 0.05).(3) By single factor analysis, there were statistically significant differences between the two groups incomplications, psychological disorders and infections between the two groups(P < 0.05).(4)The multi-factor Logistic analysis showed that there were statistically significant differences between the two groups in smoking,alcohol, drugs, intrauterine operation history, hepatitis b virus infectivities, complications, psychological disorders and infection(P < 0.05). Conclusion The clinical physicians should actively carry out healthy education in the pregnant women, develop good living habits, and strengthen pre-pregnancy inspection and publicity, so as to prevent the occurrence of miscarriage.
Objective To analyze the risk factors of 180 patients with missed abortion. Methods 180 patients with missed abortion who were treated in our hospital from January 2014 to June 2017 and 220 pregnant women who had normal pregnancy but volunteered to terminate the pregnancy(220 cases) were selected as research subjects. The age,height, weight, education level, pregnancy history, birth history, living environment, working environment, living habits, intrauterine operation history, hepatitis b virus infectivities, complications, psychological disorders,and infectious factors of pregnant womenin two groups were analyzed by single factor analysis of variance and multi-factor Logistics. Results(1) By single factor analysis, there was no statistically significant difference in age, height, weight, culture level and pregnancy history between the two groups(P > 0.05).(2) The single factor analysis showed that there were statistically significant differences between the two groups in working environment, living environment, living habits, intrauterine operation history and hepatitis b virus infectivities(P < 0.05).(3) By single factor analysis, there were statistically significant differences between the two groups incomplications, psychological disorders and infections between the two groups(P < 0.05).(4)The multi-factor Logistic analysis showed that there were statistically significant differences between the two groups in smoking,alcohol, drugs, intrauterine operation history, hepatitis b virus infectivities, complications, psychological disorders and infection(P < 0.05). Conclusion The clinical physicians should actively carry out healthy education in the pregnant women, develop good living habits, and strengthen pre-pregnancy inspection and publicity, so as to prevent the occurrence of miscarriage.
引文
[1]Zhao R,Wu Y,Zhao F,et al. The risk of missed abortion associated with the levels of tobacco, heavy metals and phthalate in hair of pregnant woman:A case control study in Chinese women[J]. Med,2017,96(51):9388-9390.
[2]Li Y,Liu X,Sun Y,et al. The Expression of PDCD4 in Patients With Missed Abortion and Its Clinical Significance[J].REPROD SCI,2017,24(11):1512-1519.
[3]陈凤英,江欢,吴巧珠.凋亡抑制基因survivin与稽留流产发病机制的相关性研究[J].中国实用医药,2017,12(18):65-66.
[4]顾华芬,衣欢,赵海红,等. 1945例稽留流产的流行病学及高危因素分析[J].生殖与避孕,2016,36(3):195-201.
[5]朱学芳,刘娟.米索前列醇与补佳乐合用治疗稽留流产的临床疗效分析[J].中国计划生育和妇产科, 2017,9(3):72-74.
[6]陈蕊,崔明双,李琴琴,等.宫腔镜配合药物治疗稽留流产43例临床观察[J].陕西医学杂志, 2017, 46(10):1404-1406.
[7]莫世盼.190例稽留流产临床相关因素的调查研究[J].黑龙江医药,2017,30(3):534-536.
[8]范小玲,刘姿.孕早期稽留流产的病因分析及清宫术后用药评价[J].湖南师范大学学报(医学版),2017,14(1):78-80.
[9]卓倩,洪安澜,马彩玲.胚胎停育相关危险因素的研究进展[J].中国优生与遗传杂志,2017(2):5-7.
[10]Wu HL,Marwah S,Wang P,et al.Misoprostol for medical treatment of missed abortion:a systematic review and network meta-analysis.[J].SCI REP,2017,7(1):145-157.
[11]胡献玉,喻兰,梁锡阳,等.稽留流产的流行性发病影响因素调查及解决对策研究[J].中国医药科学,2016,6(10):64-67.
[12]邹晴鹏.高龄孕妇稽留流产相关因素分析及早期诊断[J].中国当代医药,2017,24(19):106-108.
[13]赵志强,庞秋梅,魏宏.妊娠合并乙肝病毒感染及病毒携带者对分娩预后的影响[J].河北医药,2017,39(16):2496-2498.
[14]许翠平.乙肝病毒无症状携带者妊娠期健康状况及分娩结局的回顾性分析[J].中华临床医师杂志(电子版),2011,05(5):167-169.
[15]吴智良,杨东群,李裕华.328例稽留流产患者的相关因素病例对照研究[J].中国妇幼卫生杂志,2017(4):32-34.
[16]王贞娜.稽留流产145例发病影响因素分析[J].陕西医学杂志,2017,46(8):1072-1073.
[17]代莉.稽留流产发病的危险因素及干预对策[J].中国妇幼保健,2017,32(6):1270-1272.
[18]陈敏,徐素君,雷丽红,等. 569例稽留流产的流行病学特征及影响因素分析[J].中国妇幼健康研究,2018,12(2):146-149.
[2]Li Y,Liu X,Sun Y,et al. The Expression of PDCD4 in Patients With Missed Abortion and Its Clinical Significance[J].REPROD SCI,2017,24(11):1512-1519.
[3]陈凤英,江欢,吴巧珠.凋亡抑制基因survivin与稽留流产发病机制的相关性研究[J].中国实用医药,2017,12(18):65-66.
[4]顾华芬,衣欢,赵海红,等. 1945例稽留流产的流行病学及高危因素分析[J].生殖与避孕,2016,36(3):195-201.
[5]朱学芳,刘娟.米索前列醇与补佳乐合用治疗稽留流产的临床疗效分析[J].中国计划生育和妇产科, 2017,9(3):72-74.
[6]陈蕊,崔明双,李琴琴,等.宫腔镜配合药物治疗稽留流产43例临床观察[J].陕西医学杂志, 2017, 46(10):1404-1406.
[7]莫世盼.190例稽留流产临床相关因素的调查研究[J].黑龙江医药,2017,30(3):534-536.
[8]范小玲,刘姿.孕早期稽留流产的病因分析及清宫术后用药评价[J].湖南师范大学学报(医学版),2017,14(1):78-80.
[9]卓倩,洪安澜,马彩玲.胚胎停育相关危险因素的研究进展[J].中国优生与遗传杂志,2017(2):5-7.
[10]Wu HL,Marwah S,Wang P,et al.Misoprostol for medical treatment of missed abortion:a systematic review and network meta-analysis.[J].SCI REP,2017,7(1):145-157.
[11]胡献玉,喻兰,梁锡阳,等.稽留流产的流行性发病影响因素调查及解决对策研究[J].中国医药科学,2016,6(10):64-67.
[12]邹晴鹏.高龄孕妇稽留流产相关因素分析及早期诊断[J].中国当代医药,2017,24(19):106-108.
[13]赵志强,庞秋梅,魏宏.妊娠合并乙肝病毒感染及病毒携带者对分娩预后的影响[J].河北医药,2017,39(16):2496-2498.
[14]许翠平.乙肝病毒无症状携带者妊娠期健康状况及分娩结局的回顾性分析[J].中华临床医师杂志(电子版),2011,05(5):167-169.
[15]吴智良,杨东群,李裕华.328例稽留流产患者的相关因素病例对照研究[J].中国妇幼卫生杂志,2017(4):32-34.
[16]王贞娜.稽留流产145例发病影响因素分析[J].陕西医学杂志,2017,46(8):1072-1073.
[17]代莉.稽留流产发病的危险因素及干预对策[J].中国妇幼保健,2017,32(6):1270-1272.
[18]陈敏,徐素君,雷丽红,等. 569例稽留流产的流行病学特征及影响因素分析[J].中国妇幼健康研究,2018,12(2):146-149.
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