CalliSpheres微球联合空白微球TACE治疗中晚期肝癌的近期疗效及安全性研究

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英文篇名：Transarterial chemoembolization by using CalliSpheres drug-eluting beads combined with 8Spheres microsphere for the treatment of advanced hepatocellular carcinoma: study on its short-term efficacy and safety 作者：寸江平 ; 姜永能 ; 宗璇 ; 万程 ; 范宏杰 ; 蔡顺然 英文作者：CUN Jiangping;JIANG Yongneng;ZONG Xuan;WAN Cheng;FAN Hongjie;CAI Shunran;Department of Medical Imaging, First Affiliated Hospital of Kunming Medical University; 关键词：原发性肝癌 ; CalliSpheres ; 肝动脉化疗栓塞 ; 8Spheres栓塞微球 ; 疗效 英文关键词：primary hepatocellular carcinoma;;CalliSpheres;;transarterial chemoembolization;;8Spheres embolic microsphere;;curative efficacy 中文刊名：JRFS 英文刊名：Journal of Interventional Radiology 机构：昆明医科大学第一附属医院医学影像科; 出版日期：2019-03-25 出版单位：介入放射学杂志 年：2019 期：v.28 语种：中文; 页：JRFS201903007 页数：5 CN：03 ISSN：31-1796/R 分类号：39-43

摘要

目的探讨CalliSpheres载药微球联合空白微球(8Spheres)TACE治疗中晚期肝癌近期临床疗效和安全性。方法回顾性分析2016年7月至2017年11月行CalliSpheres载药微球联合8Spheres栓塞微球(DEB-TACE组)TACE 50例,罂粟乙碘化油联合8Spheres栓塞微球(cTACE组)48例患者的临床资料,比较两组间疾病缓解率、控制率及并发症发生率,比较两组患者术前和术后3 d肝功能指标。结果基线数据在两组间差异无统计学意义(P>0.05)。DEB-TACE组3、6个月疾病缓解率均高于cTACE组(P<0.05),且DEB-TACE组6个月疾病进展发生率、血清AFP升高率较低,近期疗效优于cTACE组(P<0.05)。术后3 d cTACE组ALT、AST较DEB-TACE组升高明显(P<0.05)。两组患者术后均无严重不良反应发生。结论 CalliSpheres载药微球联合8Spheres栓塞微球TACE在中晚期肝癌中的近期临床疗效优于罂粟乙碘油联合8Spheres栓塞微球,且安全性较高。
        Objective To investigate the clinical short-term efficacy and safety of transarterial chemoembolization(TACE) by using CalliSpheres drug-eluting beads combined with blank microspheres(8 Spheres) in treating advanced hepatocellular carcinoma(HCC). Methods The clinical data of 98 HCC patients, who were treated at authors′ hospital during the period from July 2016 to November 2017, were retrospectively analyzed. The patients were divided into DEB-TACE group(receiving TACE by using CalliSpheres drug-eluting beads combined with 8 Spheres embolic microspheres, n =50) and cTACE group(receiving TACE by using opium poppy ethyl iodized oil together with 8 Spheres embolic microspheres, n =48). The disease remission rate, control rate and incidence of complications as well as preoperative and 3-day postoperative hepatic function indexes were collected, and the results were compared between the two groups. Results No statistically significant differences in baseline data existed between the two groups(P>0.05). Both the 3-month and the 6-month disease remission rates in DEB-TACE group were remarkably higher than those in cTACE group(P<0.05), besides, the 6-month disease progression rate and the incidence of elevated serum AFP in DEB-TACE group were lower than those in cTACE group, the short-term efficacy of DEB-TACE group was better than that of cTACE group(P<0.05). Three days after treatment, the levels of ALT and AST in cTACE group were strikingly higher than those in DEB-TACE group(P<0.05). No serious adverse reactions occurred in both groups. Conclusion In treating advanced HCC with TACE, the short-term efficacy and safety of CalliSpheres drug-eluting beads combined with 8 Spheres embolic microspheres are superior to those of opium poppy ethyl iodized oil together with 8 Spheres embolic microspheres.

引文

[1] Fateen W, Khan F, O'neill RJ, et al. Healthcare costs of transarterial chemoembolization in the treatment of hepatocellular carcinoma[J]. J Hepatocell Carcinoma, 2017, 4:123-130.
    [2]乔彬彬,虞希祥,王舒婷,等. TACE术中灌注氟尿嘧啶、奥沙利铂及吡柔比星治疗原发性肝癌的临床效果分析[J].介入放射学杂志, 2015, 24:349-353.
    [3] Asayama Y, Okamoto D, Ushijima Y, et al. Predictors of therapeutic effect of transarterial chemoembolisation using drugeluting beads for hepatocellular carcinoma[J]. Clin Radiol, 2017,72:780-785.
    [4] Wu B, Zhou J, Ling G, et al. CalliSpheres drug-eluting beads versus lipiodol transarterial chemoembolization in the treatment of hepatocellular carcinoma:a short-term efficacy and safety study[J]. World J Surg Oncol, 2018, 16:69.
    [5]姜松,李桂杰,周祝谦,等. CalliSpheres载药栓塞微球治疗中晚期肝癌临床效果评价[J].中华介入放射学电子杂志, 2017,5:174-178.
    [6]王亚勋,吴宝林,周军,等.载药微球与空白微球栓塞治疗原发性肝癌的对比分析研究[J].影像诊断与介入放射学,2017, 26:445-450.
    [7] Zhang S, Huang C, Li Z, et al. Comparison of pharmacokinetics and drug release in tissues after transarterial chemoembolization with doxorubicin using diverse lipiodol emulsions and CalliSpheres Beads in rabbit livers[J]. Drug Deliv, 2017, 24:1011-1017.
    [8]刘金,曹刚,张根山,等.国产CalliSpheres载药微球治疗原发性肝癌12例[J].介入放射学杂志, 2017, 26:993-998.
    [9] Recchia F, Passalacqua G, Filauri P, et al. Chemoembolization of unresectable hepatocellular carcinoma:decreased toxicity with slow-release doxorubicin-eluting beads compared with lipiodol[J]. Oncol Rep, 2012, 27:1377-1383.