早期康复联合丁苯酞注射液治疗急性脑梗塞的效果及对肢体功能和日常生活能力的影响
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摘要
目的探讨早期康复联合丁苯酞注射液治疗急性脑梗塞的效果及对肢体功能与日常生活能力的影响。方法选择本科室80例急性脑梗塞患者为研究对象,按照随机数表法将患者分为常规组(n=40)和干预组(n=40)。常规组给予丁苯酞注射液治疗,干预组实施早期康复联合丁苯酞注射液治疗。比较两组患者的治疗效果。结果治疗2周后,两组超氧化物歧化酶及丙二醛水平均改善,且干预组优于常规组(P<0.05)。治疗2周后,两组肿瘤坏死因子-α及白细胞介素-6水平均降低,且干预组低于常规组(P<0.05)。治疗2周后,两组碱性成纤维细胞生长因子、脑源性神经营养因子水平均改善,且干预组优于常规组(P<0.05)。治疗2周后,两组上、下肢功能、日常生活能力评分及GOS评分均升高,且干预组高于常规组(P<0.05)。结论早期康复联合丁苯酞注射液治疗急性脑梗塞可有效抑制氧化应激反应及炎性因子水平,还可改善患者神经营养状态、肢体功能、日常生活能力及预后。
Objective To investigate the effect of early rehabilitation combined with butylphthalide injection in the treatment of acute cerebral infarction and the influence on limb function and activity of daily living. Methods Eighty patients with acute cerebral infarction in our department were selected as the study objects. The patients were divided into routine group(n=40) and intervention group(n=40) by random number table method. The routine group was treated with butylphthalide injection, while the intervention group was treated with early rehabilitation combined with butylphthalide injection. The therapeutic effects of the two groups were compared. Results After 2 weeks of treatment, the levels of superoxide dismutase and malondialdehyde improved in both groups, and those in the intervention group were better than the routine group(P<0.05). After 2 weeks of treatment, the levels of tumor necrosis factor-α and interleukin-6 in both groups decreased, and those in the intervention group were lower than the routine group(P <0.05). After 2 weeks of treatment, the levels of basic fibroblast growth factor and brain-derived neurotrophic factor in both groups improved, and those in the intervention group were better than the routine group( P <0.05). After 2 weeks of treatment, the scores of upper and lower limbs function, activity of daily living and GOS increased in both groups, and those in the intervention group were higher than the routine group(P<0.05). Conclusion Early rehabilitation combined with butylphthalide injection can effectively inhibit oxidative stress response and secretion of inflammatory factors in patients with acute cerebral infarction, and improve neurotrophic status, limb function, activity of daily living and prognosis.
Objective To investigate the effect of early rehabilitation combined with butylphthalide injection in the treatment of acute cerebral infarction and the influence on limb function and activity of daily living. Methods Eighty patients with acute cerebral infarction in our department were selected as the study objects. The patients were divided into routine group(n=40) and intervention group(n=40) by random number table method. The routine group was treated with butylphthalide injection, while the intervention group was treated with early rehabilitation combined with butylphthalide injection. The therapeutic effects of the two groups were compared. Results After 2 weeks of treatment, the levels of superoxide dismutase and malondialdehyde improved in both groups, and those in the intervention group were better than the routine group(P<0.05). After 2 weeks of treatment, the levels of tumor necrosis factor-α and interleukin-6 in both groups decreased, and those in the intervention group were lower than the routine group(P <0.05). After 2 weeks of treatment, the levels of basic fibroblast growth factor and brain-derived neurotrophic factor in both groups improved, and those in the intervention group were better than the routine group( P <0.05). After 2 weeks of treatment, the scores of upper and lower limbs function, activity of daily living and GOS increased in both groups, and those in the intervention group were higher than the routine group(P<0.05). Conclusion Early rehabilitation combined with butylphthalide injection can effectively inhibit oxidative stress response and secretion of inflammatory factors in patients with acute cerebral infarction, and improve neurotrophic status, limb function, activity of daily living and prognosis.
引文
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[8]周经霞,陈擘璨,陈聪,等.丁苯酞注射液联合基础药物治疗急性脑梗死不同时间患者日常生活能力评价[J].河北医药,2016,38(20):3121-3123.
[9]李凝香,雷新锋,边亚礼,等.丁苯酞联合舒血宁对血管性痴呆患者认知功能和日常生活能力的影响[J].中国中西医结合急救杂志,2017,24(6):586-589.
[10]陈炜,张之福,杨宝玲,等.早期康复治疗脑梗死急性期患者运动功能障碍的效果[J].神经损伤与功能重建,2015,10(1):43-45.
[2]濮捷,崔敏,吴非,等.阿替普酶联合丁苯酞注射液对超早期缺血性卒中患者神经功能缺损的影响分析[J].湖南师范大学学报:医学版,2016,13(1):103-105.
[3]白丽虹,张燕如.丁苯酞注射液联合低分子肝素钙治疗进展性脑梗死的临床效果[J].中国老年学杂志,2016,36(10):2394-2396.
[4]陈艳丽.高压氧联合早期康复治疗对急性脑梗死患者的疗效观察[J].中国实用神经疾病杂志,2016,19(22):36-37.
[5]陈欣,马赟英,关兰芳,等.丁苯酞注射液联合低分子肝素钙治疗进展性脑梗死的临床效果探讨[J].中国继续医学教育,2016,8(28):155-156.
[6]肖桂荣,王赵伟,朱仁洋,等.丁苯酞注射液联合依达拉奉治疗急性脑梗死的疗效观察[J].中国神经免疫学和神经病学杂志,2016,23(1):51-54.
[7]高琦,黄玉雕,张忠波,等.丁苯酞注射液联合依达拉奉治疗急性脑梗死的疗效观察[J].中国实用医药,2017,12(21):129-130.
[8]周经霞,陈擘璨,陈聪,等.丁苯酞注射液联合基础药物治疗急性脑梗死不同时间患者日常生活能力评价[J].河北医药,2016,38(20):3121-3123.
[9]李凝香,雷新锋,边亚礼,等.丁苯酞联合舒血宁对血管性痴呆患者认知功能和日常生活能力的影响[J].中国中西医结合急救杂志,2017,24(6):586-589.
[10]陈炜,张之福,杨宝玲,等.早期康复治疗脑梗死急性期患者运动功能障碍的效果[J].神经损伤与功能重建,2015,10(1):43-45.
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