羊乳粉与牛乳粉引起乳糖不耐反应的比较
|
摘要
背景部分牛乳粉乳糖不耐受者食用羊乳粉后症状减轻甚至没有乳糖不耐受症状,是个别现象还是普遍现象?该类人群在乳糖不耐受者中占比多少?目前相关研究较少。目的研究对于成年牛乳粉乳糖不耐受者,羊乳粉引起的乳糖不耐受发生率及胃肠道反应是否与牛乳粉不同。方法 2017年9—12月,采用自身对照设计,受试者空腹饮用300 ml牛乳(40 g牛乳粉),其中乳糖吸收不良或乳糖不耐受者经过7 d的洗脱期后,饮用等量羊乳粉。饮乳粉后2 h采用尿半乳糖比色法进行乳糖耐受性检测,2次试验均采用饮用牛乳粉/羊乳粉后12 h症状调查问卷调查受试者腹胀及腹痛的首次发作时间、持续时间、严重程度及排便增加次数。结果饮牛乳粉后乳糖吸收不良或乳糖不耐受发生率为93.3%(112/120),饮羊乳粉后乳糖吸收不良或乳糖不耐受发生率为94.6%(106/112),饮牛乳粉与饮羊乳粉后乳糖耐受性比较,差异无统计学意义(P>0.05)。饮用两种乳粉乳糖吸收不良或乳糖不耐受者腹胀及腹痛首次发作时间、持续时间及严重程度评分差异均无统计学意义(P>0.05);饮用两种乳粉后排便增加发作时间比较,差异无统计学意义(P>0.05),排便增加次数比较,差异有统计学意义(P<0.05)。结论饮用牛乳粉乳糖吸收不良或乳糖不耐受的人群饮用羊乳粉大多仍为乳糖不耐受,饮羊乳粉后排便次数增加,腹痛、腹胀等症状无明显差别。对于乳糖吸收不良或乳糖不耐受的人群,饮乳前可选择应用乳糖酶或饮用不含乳糖的乳制品。
Background The adults with partial lactose intolerance caused by drinking cow milk powder solution have reduced or disappeared symptoms after drinking goat milk powder solution.However,there is no available research evidence concerning whether it is an individual or a common phenomenon,and the proportion of such people in lactose intolerance group.Objective To make a comparative analysis of lactose intolerance and gastrointestinal reactions caused by drinking goat and cow milk powder solutions in Chinese adults.Methods This study was conducted from September to December 2017 following a self-controlled design.Participants first drank 300 ml cow milk powder solution(with 40 g cow milk powder dissolved) with empty stomach.Those with lactose malabsorption or intolerance drank the same amount of goat milk powder solution(with 40 g goat milk powder dissolved) with empty stomach after a 7-day washout period.Lactose intolerance was evaluated by the urinary galactose level measured by colorimetric assay at 2 hours after drinking the milk.Symptoms Checklist at 12 Hours after Drinking Cow or Goat Milk Powder Solution was used to assess the first onset time,duration and severity of abdominal distension and pain,and the increase in the number of bowel movements.Results After drinking cow milk powder solution,the incidence of lactose malabsorption or intolerance was 93.3%(112/120) in participants,which was similar to that[94.6%(106/112)]after drinking goat milk powder solution(P>0.05).Furthermore,the evaluation scores for lactose malabsorption or intolerancerelated symptoms such as the first onset time,duration,and severity of abdominal distension and pain,and episode lengths of bowel movements caused by drinking cow and goat milk powder solutions were similar(P>0.05),but the scores for increased frequency of post-drinking bowel movements were significantly different(P<0.05).Conclusion After drinking goat milk powder solution,most adults with lactose malabsorption or intolerance caused by drinking cow milk powder solution also showed lactose intolerance.Moreover,they demonstrated similar increased bowel movements and abdominal pain and distention.These people had better have lactase solution or lactose-free dairy products before drinking cow or goat milk powder solution.
Background The adults with partial lactose intolerance caused by drinking cow milk powder solution have reduced or disappeared symptoms after drinking goat milk powder solution.However,there is no available research evidence concerning whether it is an individual or a common phenomenon,and the proportion of such people in lactose intolerance group.Objective To make a comparative analysis of lactose intolerance and gastrointestinal reactions caused by drinking goat and cow milk powder solutions in Chinese adults.Methods This study was conducted from September to December 2017 following a self-controlled design.Participants first drank 300 ml cow milk powder solution(with 40 g cow milk powder dissolved) with empty stomach.Those with lactose malabsorption or intolerance drank the same amount of goat milk powder solution(with 40 g goat milk powder dissolved) with empty stomach after a 7-day washout period.Lactose intolerance was evaluated by the urinary galactose level measured by colorimetric assay at 2 hours after drinking the milk.Symptoms Checklist at 12 Hours after Drinking Cow or Goat Milk Powder Solution was used to assess the first onset time,duration and severity of abdominal distension and pain,and the increase in the number of bowel movements.Results After drinking cow milk powder solution,the incidence of lactose malabsorption or intolerance was 93.3%(112/120) in participants,which was similar to that[94.6%(106/112)]after drinking goat milk powder solution(P>0.05).Furthermore,the evaluation scores for lactose malabsorption or intolerancerelated symptoms such as the first onset time,duration,and severity of abdominal distension and pain,and episode lengths of bowel movements caused by drinking cow and goat milk powder solutions were similar(P>0.05),but the scores for increased frequency of post-drinking bowel movements were significantly different(P<0.05).Conclusion After drinking goat milk powder solution,most adults with lactose malabsorption or intolerance caused by drinking cow milk powder solution also showed lactose intolerance.Moreover,they demonstrated similar increased bowel movements and abdominal pain and distention.These people had better have lactase solution or lactose-free dairy products before drinking cow or goat milk powder solution.
引文
[1]JACKSON K A,SAVAIANO D A.Lactose maldigestion,calcium intake and osteoporosis in African-,Asian-,and HispanicAnericans[J].J Am Coll Nutri,2001,20(2 suppl):198s-207s.
[2]钟燕.乳糖不耐受基础研究进展[J].国外医学卫生学分册,2000,27(3):168-171.ZHONG Y.Progress in basic research on lactose intolerance[J].Foreign Medicine:Health Section,2000,27(3):168-171.
[3]中国营养学会.中国居民膳食指南(2016)[M].北京:人民卫生出版社,2016.
[4]张文静.轮状病毒感染与继发婴幼儿乳糖不耐受的相关分析[J].国际检验医学杂志,2015,36(2):183-184.ZHANG W J.Correlation analysis between rotavirus infection and lactose intolerance in secondary infants[J].International Journal of Laboratory Medicine,2015,36(2):183-184.(下转第446页)
[5]符芳姿,王哲,许振胜,等.中药联合艾灸治疗腹泻型肠易激综合征的临床研究[J].广州中医药大学学报,2018,35(6):1026-1030.FU F Z,WANG Z,XU Z S,et al.Clinical study of traditional Chinese medicine combined with moxibustion on diarrheapredominant irritable bowel syndrome[J].Journal of Guangzhou University of Traditional Chinese Medicine,2018,35(6):1026-1030.
[6]SHAW A D,DAVIES G J.Lactose into lerance:problems in diagnosis and treatment[J].J Clin Gastroenterol,1999,28(3):208-216.
[7]杨富春,任立红,孙维佳.药物性腹泻病与乳糖酶的关系研究[J].现代保健,2007,4(2):19-20.YANG F C,REN L H,SUN W J.The research of the relationship between drug-induced diarrhea and lactase[J].Modern Health,2007,4(2):19-20.
[8]LEWINSKY R H,JENSEN T G K,M?LLER J,et al.T-13910DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro[J].Human Molecular Genetics,2005,14(24):3945-3953.
[9]RIDEFELT P,H?KANSSON L D.Lactose intolerance:lactose tolerance test versus genotyping scand[J].Gastroenterol,2005,40(7):822-826.
[10]关晓辉,徐洪军,张晓杰,等.不同年龄段人群乳糖酶缺乏的临床研究[J].中华内科杂志,2006,45(6):497-498.GUAN X H,XU H J,ZHANG X J,et al.Clinical study of lactase deficiency in different age groups[J].Chinese Journal of Internal Medicine,2006,45(6):497-498.
[11]刘洪波,施兆红.山羊奶:现代人类健康的营养佳品[J].中国畜牧杂志,2005,41(11):52-53.LIU H B,SHI Z H.Goat milk:a good nutrition for modern human health[J].Chinese Journal of Animal Husbandry,2005,41(11):52-53.
[12]徐宗.人乳、牛乳与儿童营养[J].食品科学,1981,2(10):3-10.XU Z.Breast milk,cow's milk and child nutrition[J].Food Science,1981,2(10):3-10.
[13]焦凌梅,袁唯.改善山羊乳风味的方法研究[J].中国乳业,2006,13(6):56-58.JIAO L M,YUAN W.Study on the method of improving the flavor of goat milk[J].China Dairy,2006,13(6):56-58.
[14]王慧斌,梁瑛.山羊奶与牛奶相关性能的比较[J].畜牧生产,2011,32(10):23-24.WANG H B,LIANG Y.Comparison of goat milk and cow milk related performance[J].Animal Production,2011,32(10):23-24.
[15]乔蓉,黄承钰,曾果,等.健康成人可接受牛奶摄入量实验研究[J].卫生研究,2006,35(6):747-749.QIAO R,HUANG C Y,ZENG G,et al.Experimental study on the amount of cow milk intake acceptable to healthy adults[J].Health Research,2006,35(6):747-749.
[2]钟燕.乳糖不耐受基础研究进展[J].国外医学卫生学分册,2000,27(3):168-171.ZHONG Y.Progress in basic research on lactose intolerance[J].Foreign Medicine:Health Section,2000,27(3):168-171.
[3]中国营养学会.中国居民膳食指南(2016)[M].北京:人民卫生出版社,2016.
[4]张文静.轮状病毒感染与继发婴幼儿乳糖不耐受的相关分析[J].国际检验医学杂志,2015,36(2):183-184.ZHANG W J.Correlation analysis between rotavirus infection and lactose intolerance in secondary infants[J].International Journal of Laboratory Medicine,2015,36(2):183-184.(下转第446页)
[5]符芳姿,王哲,许振胜,等.中药联合艾灸治疗腹泻型肠易激综合征的临床研究[J].广州中医药大学学报,2018,35(6):1026-1030.FU F Z,WANG Z,XU Z S,et al.Clinical study of traditional Chinese medicine combined with moxibustion on diarrheapredominant irritable bowel syndrome[J].Journal of Guangzhou University of Traditional Chinese Medicine,2018,35(6):1026-1030.
[6]SHAW A D,DAVIES G J.Lactose into lerance:problems in diagnosis and treatment[J].J Clin Gastroenterol,1999,28(3):208-216.
[7]杨富春,任立红,孙维佳.药物性腹泻病与乳糖酶的关系研究[J].现代保健,2007,4(2):19-20.YANG F C,REN L H,SUN W J.The research of the relationship between drug-induced diarrhea and lactase[J].Modern Health,2007,4(2):19-20.
[8]LEWINSKY R H,JENSEN T G K,M?LLER J,et al.T-13910DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro[J].Human Molecular Genetics,2005,14(24):3945-3953.
[9]RIDEFELT P,H?KANSSON L D.Lactose intolerance:lactose tolerance test versus genotyping scand[J].Gastroenterol,2005,40(7):822-826.
[10]关晓辉,徐洪军,张晓杰,等.不同年龄段人群乳糖酶缺乏的临床研究[J].中华内科杂志,2006,45(6):497-498.GUAN X H,XU H J,ZHANG X J,et al.Clinical study of lactase deficiency in different age groups[J].Chinese Journal of Internal Medicine,2006,45(6):497-498.
[11]刘洪波,施兆红.山羊奶:现代人类健康的营养佳品[J].中国畜牧杂志,2005,41(11):52-53.LIU H B,SHI Z H.Goat milk:a good nutrition for modern human health[J].Chinese Journal of Animal Husbandry,2005,41(11):52-53.
[12]徐宗.人乳、牛乳与儿童营养[J].食品科学,1981,2(10):3-10.XU Z.Breast milk,cow's milk and child nutrition[J].Food Science,1981,2(10):3-10.
[13]焦凌梅,袁唯.改善山羊乳风味的方法研究[J].中国乳业,2006,13(6):56-58.JIAO L M,YUAN W.Study on the method of improving the flavor of goat milk[J].China Dairy,2006,13(6):56-58.
[14]王慧斌,梁瑛.山羊奶与牛奶相关性能的比较[J].畜牧生产,2011,32(10):23-24.WANG H B,LIANG Y.Comparison of goat milk and cow milk related performance[J].Animal Production,2011,32(10):23-24.
[15]乔蓉,黄承钰,曾果,等.健康成人可接受牛奶摄入量实验研究[J].卫生研究,2006,35(6):747-749.QIAO R,HUANG C Y,ZENG G,et al.Experimental study on the amount of cow milk intake acceptable to healthy adults[J].Health Research,2006,35(6):747-749.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |