2011-2017年苏州市区5岁以下儿童流感相关门诊就诊率的估计
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摘要
目的估计2011-2017年苏州市区5岁以下儿童流感相关流感样病例(influenzalike illness,ILI)就诊率。方法 2011年10月～2017年3月,在苏州大学附属儿童医院门急诊室开展对5岁以下儿童ILI病例的监测。收集咽拭子标本并采用实时定量逆转录-聚合酶链反应进行流感病毒检测。同时基于卫生服务利用数据及人口学数据,估计苏州市区5岁以下儿童流感相关ILI就诊数和就诊率。结果 2011-2017年苏州市区约有45 930例次5岁以下流感相关ILI病例,其中因流感病毒A/H1N1感染就诊的ILI病例7 490例,A/H3N2就诊数为17 843例,B就诊数为20 597例。研究期间,苏州市区5岁以下儿童流感相关ILI病例的就诊率为6. 4/100人年,其中2011-2012年流感相关ILI就诊率最高,达20. 5/100人年,2012-2013年最低,为2. 4/100人年。结论苏州市区5岁以下的儿童流感相关ILI就诊数和就诊率较高,疾病负担较大。
Objective To estimate the outpatient rate of influenza-related influenza-like illness( ILI) for children younger than 5 years in Suzhou municipal districts. Methods From October 2011 to March 2017,we conducted a prospective surveillance program on ILI for children under 5 years in outpatient settings of Soochow University Affiliated Children's Hospital( SCH). The throat swabs were collected and tested for influenza viruses by RT-PCR. Based on the healthcare utilization surveys and population data,the number of visits and the outpatient rate of influenza-related ILI for children younger than 5 years in Suzhou municipal districts were estimated. Results During 2011-2017,in total,there were 45 930 estimated influenza-related ILI cases younger than 5 years in Suzhou municipal districts,which consisted of 7 490 influenza A/H1 N1 cases,17 843 influenza A/H3 N2 cases and 20 597 influenza B cases. The estimated outpatient rate of influenza-related ILI was 6. 4% in 2011-2017,which was highest in 2011-2012,20. 5%,and the lowest in 2012-2013,2. 4%. Conclusion The number of visits and the outpatient rate of influenza-related ILI in children younger than 5 years was high in Suzhou municipal districts.
Objective To estimate the outpatient rate of influenza-related influenza-like illness( ILI) for children younger than 5 years in Suzhou municipal districts. Methods From October 2011 to March 2017,we conducted a prospective surveillance program on ILI for children under 5 years in outpatient settings of Soochow University Affiliated Children's Hospital( SCH). The throat swabs were collected and tested for influenza viruses by RT-PCR. Based on the healthcare utilization surveys and population data,the number of visits and the outpatient rate of influenza-related ILI for children younger than 5 years in Suzhou municipal districts were estimated. Results During 2011-2017,in total,there were 45 930 estimated influenza-related ILI cases younger than 5 years in Suzhou municipal districts,which consisted of 7 490 influenza A/H1 N1 cases,17 843 influenza A/H3 N2 cases and 20 597 influenza B cases. The estimated outpatient rate of influenza-related ILI was 6. 4% in 2011-2017,which was highest in 2011-2012,20. 5%,and the lowest in 2012-2013,2. 4%. Conclusion The number of visits and the outpatient rate of influenza-related ILI in children younger than 5 years was high in Suzhou municipal districts.
引文
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[10]颜玉炳,蒋丽娜,刘红莲,等.流感样病例中流感病毒阳性检出率的相关因素分析[J].中华疾病控制杂志,2015,19(3):310-312.DOI:10.16462/j.cnki.zhjbkz.2015.03.026.Yan YB,Jiang LN,Liu HL,et al.Analysis of related factors of influenza virus positive rate in influenza-like illness.[J].Chin JDis Control Prev,2015,19(3):310-312.DOI:10.16462/j.cnki.zhjbkz.2015.03.026.
[11]张涛,陈健,王丹,等.2009年甲型H1N1流感大流行期间上海市人群甲型H1N1流感疫苗接种前流感感染率调查[J].中华疾病控制杂志,2011,15(1):29-32.Zhang T,Chen J,Wang D,et al.Investigation on the infection rate of influenza A(H1N1)before vaccination in Shanghai population during the influenza A(H1N1)pandemic in 2009[J].Chin J Dis Control Prev,2011,15(1):29-32.
[12]Tokars JI,Olsen SJ,Reed C.Seasonal incidence of symptomatic influenza in the United States[J].Clin Infect Dis,2018,66(10):1511-1518.DOI:10.1093/cid/cix1060.
[13]Jackson ML,Jackson LA,Kieke B,et al.Incidence of medically attended influenza infection and cases averted by vaccination,2011/2012 and 2012/2013 influenza seasons[J].Vaccine,2015,33(39):5181-5187.DOI:10.1016/j.vaccine.2015.07.098.
[14]Caini S,Spreeuwenberg P,Kusznierz GF,et al.Distribution of influenza virus types by age using case-based global surveillance data from twenty-nine countries,1999-2014[J].BMC Infect Dis,2018,18(1):269.DOI:10.1186/s12879-018-3181-y.
[15]Wei VWI,Wong JYT,Perera RAPM,et al.Incidence of influenza A(H3N2)virus infections in Hong Kong in a longitudinal seroepidemiological study,2009-2015[J].PLo S One,2018,13(5):e197504.DOI:10.1371/journal.pone.0197504.
[16]崔燕,周艳冰,王瑞,等.2009-2013年上海市普陀区流感样病例监测及流行特征分析[J].中华疾病控制杂志,2015,19(6):638-640.DOI:10.16462/j.cnki.zhjbkz.2015.06.027.Cui Y,Zhou YB,Wang R,et al.Surveillance and epidemic characteristics analysis of influenza-like illness in Putuo district,Shanghai from 2009 to 2013[J].Chin J Dis Control Prev,2015,19(6):638-640.DOI:10.16462/j.cnki.zhjbkz.2015.06.027.
[2]Iuliano AD,Roguski KM,Chang HH,et al.Estimates of global seasonal influenza-associated respiratory mortality:a modelling study[J].Lancet,2018,391(10127):1285-1300.DOI:10.1016/S0140-6736(17)33293-2.
[3]Poehling KA,Edwards KM,Weinberg GA,et al.The underrecognized burden of influenza in young children[J].N Engl J Med,2006,355(1):31-40.DOI:10.1056/NEJMoa054869.
[4]Wang D,Chen L,Ding Y,et al.Viral etiology of medically attended influenza-like illnesses in children less than five years old in Suzhou,China,2011-2014[J].J Med Virol,2016,88(8):1334-1340.DOI:10.1002/jmv.24480.
[5]江艳微,华军,吴婧,等.苏州地区5岁以下严重急性呼吸道感染(SARI)住院患儿的病毒病原学和临床特征分析[J].复旦学报(医学版),2013(4):407-412.DOI:10.3969/j.issn.1672-8467.2013.04.006.Jiang YW,Hua J,Wu J,et al.Analysis of viral etiology and clinical characteristics of hospitalized children younger than 5 years with severe acute respiratory infection(SARI)in Suzhou.[J].Fudan Univ J Med,2013(4):407-412.DOI:10.3969/j.issn.1672-8467.2013.04.006.
[6]Zhang T,Zhang J,Hua J,et al.Influenza-associated outpatient visits among children less than 5 years of age in eastern China,2011-2014[J].BMC Infect Dis,2016,16:267.DOI:10.1186/s12879-016-1614-z.
[7]Neuzil KM,Hohlbein C,Zhu Y.Illness among schoolchildren during influenza season:effect on school absenteeism,parental absenteeism from work,and secondary illness in families[J].Arch Pediatr Adolesc Med,2002,156(10):986-991.DOI:10.1001/archpedi.156.10.986.
[8]Wang D,Zhang T,Wu J,et al.Socio-economic burden of influenza among children younger than 5 years in the outpatient setting in Suzhou,China[J].PLo S One,2013,8(8):e69035.DOI:10.1371/journal.pone.0069035.
[9]于佳,张涛,王胤,等.苏州市某院2011-2016年5岁以下儿童流行性感冒流行病学与临床特征分析[J].上海预防医学,2016(11):801-805.DOI:10.19428/j.cnki.sjpm.2016.11.014.Yu J,Zhang T,Wang Y,et al.Epidemiological and clinical characteristics analysis of influenza among children younger than 5years in a hospital in Suzhou from 2011 to 2016[J].Shanghai JPrev Med,2016(11):801-805.DOI:10.19428/j.cnki.sjpm.2016.11.014.
[10]颜玉炳,蒋丽娜,刘红莲,等.流感样病例中流感病毒阳性检出率的相关因素分析[J].中华疾病控制杂志,2015,19(3):310-312.DOI:10.16462/j.cnki.zhjbkz.2015.03.026.Yan YB,Jiang LN,Liu HL,et al.Analysis of related factors of influenza virus positive rate in influenza-like illness.[J].Chin JDis Control Prev,2015,19(3):310-312.DOI:10.16462/j.cnki.zhjbkz.2015.03.026.
[11]张涛,陈健,王丹,等.2009年甲型H1N1流感大流行期间上海市人群甲型H1N1流感疫苗接种前流感感染率调查[J].中华疾病控制杂志,2011,15(1):29-32.Zhang T,Chen J,Wang D,et al.Investigation on the infection rate of influenza A(H1N1)before vaccination in Shanghai population during the influenza A(H1N1)pandemic in 2009[J].Chin J Dis Control Prev,2011,15(1):29-32.
[12]Tokars JI,Olsen SJ,Reed C.Seasonal incidence of symptomatic influenza in the United States[J].Clin Infect Dis,2018,66(10):1511-1518.DOI:10.1093/cid/cix1060.
[13]Jackson ML,Jackson LA,Kieke B,et al.Incidence of medically attended influenza infection and cases averted by vaccination,2011/2012 and 2012/2013 influenza seasons[J].Vaccine,2015,33(39):5181-5187.DOI:10.1016/j.vaccine.2015.07.098.
[14]Caini S,Spreeuwenberg P,Kusznierz GF,et al.Distribution of influenza virus types by age using case-based global surveillance data from twenty-nine countries,1999-2014[J].BMC Infect Dis,2018,18(1):269.DOI:10.1186/s12879-018-3181-y.
[15]Wei VWI,Wong JYT,Perera RAPM,et al.Incidence of influenza A(H3N2)virus infections in Hong Kong in a longitudinal seroepidemiological study,2009-2015[J].PLo S One,2018,13(5):e197504.DOI:10.1371/journal.pone.0197504.
[16]崔燕,周艳冰,王瑞,等.2009-2013年上海市普陀区流感样病例监测及流行特征分析[J].中华疾病控制杂志,2015,19(6):638-640.DOI:10.16462/j.cnki.zhjbkz.2015.06.027.Cui Y,Zhou YB,Wang R,et al.Surveillance and epidemic characteristics analysis of influenza-like illness in Putuo district,Shanghai from 2009 to 2013[J].Chin J Dis Control Prev,2015,19(6):638-640.DOI:10.16462/j.cnki.zhjbkz.2015.06.027.
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