~(18)F-FDG PET/CT与增强MRI在妇科恶性肿瘤中的诊断价值比较

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英文篇名：Value of ~(18)F-FDG PET/CT versus MRI to the diagnosis of gynecological malignant tumors 作者：申景涛 ; 辛小燕 ; 贾支俊 ; 孙一文 ; 陈宇 ; 冯雪凤 ; 李宝新 英文作者：SHEN Jingtao;XIN Xiaoyan;JIA Zhijun;SUN Yiwen;CHEN Yu;FENG Xuefeng;LI Baoxin;Department of Nuclear Medicine,Drum Tower Hospital Affiliated to Nanjing University Medical School;Department of Radiology,Drum Tower Hospital Affiliated to Nanjing University Medical School;Department of Radiology,Gaochun District People's Hospital; 关键词：妇科恶性肿瘤 ; ~(18)F-氟代脱氧葡萄糖 ; 正电子发射计算机断层成像/CT ; MRI 英文关键词：gynecological malignant tumors;;~(18)F-fluorodeoxyglucose;;positron emission tomography/CT;;MRI 中文刊名：HNZD 英文刊名：Journal of Chinese Practical Diagnosis and Therapy 机构：南京大学医学院附属鼓楼医院核医学科;南京大学医学院附属鼓楼医院医学影像科;高淳人民医院放射科; 出版日期：2019-02-01 08:51 出版单位：中华实用诊断与治疗杂志 年：2019 期：v.33 基金：江苏省“六大人才高峰”高层次人才项目(2016-WSN-160);; 南京市医学科技发展一般性课题(YKK17058);; 南京市卫生科技发展专项资金项目医药卫生科研课题(YKK18062) 语种：中文; 页：HNZD201902016 页数：4 CN：02 ISSN：41-1400/R 分类号：61-64

摘要

目的探讨~(18)F-氟代脱氧葡萄糖(~(18)F-fluorodeoxyglucose,~(18)F-FDG)正电子发射计算机断层成像(positron emissiontomography,PET)/CT与MRI在妇科恶性肿瘤诊断中的应用价值。方法 120例妇科肿瘤患者,经手术切除组织病理或穿刺活检组织病理检查确诊恶性肿瘤46例,良性肿瘤74例,术前均接受~(18) F-FDG PET/CT显像检查、MRI检查。比较良、恶性肿瘤病灶标准摄取(standard uptake value,SUV)最大值(SUVmax值)差异,计算~(18) F-FDG PET/CT及MRI检查诊断妇科恶性肿瘤的灵敏度、特异度和准确度,比较~(18) F-FDG PET/CT、MRI对不同类型妇科恶性肿瘤的诊断符合率。结果恶性肿瘤SUVmax值(9.85±3.97)高于良性肿瘤(2.39±1.28)(P<0.05);18 F-FDG PET/CT诊断妇科恶性肿瘤的灵敏度(95.65%)、特异度(95.95%)、准确度(95.83%)均高于MRI(80.43%、86.49%、84.17%)(P<0.05);~(18)F-FDG PET/CT对宫颈癌、子宫内膜癌的诊断符合率(95.24%、94.44%)均高于MRI(71.43%、66.67%)(P<0.05),对卵巢癌的诊断符合率(85.71%)与MRI(71.43%)比较差异无统计学意义(P>0.05)。结论 ~(18) F-FDG PET/CT对妇科恶性肿瘤具有诊断价值,其诊断准确性优于MRI,可作为妇科恶性肿瘤影像学诊断的主要手段。
        Objective To study and compare the value between ~(18) F-fluorodeoxyglucose(~(18) F-FDG)positron emission tomography/CT(PET/CT)and MRI to the diagnosis of gynecological malignant tumors.Methods In 120 patients with gynecological tumors,46 patients with malignant tumors and 74 patients with benign tumors were confirmed by histopathologic examination.All patients were examined by ~(18) F-FDG PET/CT and MRI examination before operation.The differences of the maximal standard uptake value(SUVmax)were compared between malignant and benign tumors.The sensitivity,specificity and accuracy of ~(18) F-FDG PET/CT and MRI for the diagnosis of gynecological malignant tumors were calculated,and the diagnostic accordance rates of ~(18) F-FDG PET/CT and MRI for different types of gynecological malignant tumors were compared.Results The SUVmax was significantly higher in malignant tumors(9.85±3.97)than that in benign tumors(2.39±1.28)(P<0.05).The sensitivity,specificity and accuracy of ~(18) F-FDG PET/CT for the diagnosis of gynecological malignant tumors were 95.65%,95.95% and 95.83% respectively,significantly higher than those of MRI(80.43%,86.49%,84.17%)(P<0.05).The diagnostic accordance rates of~(18) F-FDG PET/CT for cervical cancer and endometrial cancer were 95.24%and 94.44%respectively,significantly higher than those of MRI(71.43%,66.67%)(P<0.05).Conclusion ~(18) F-FDG PET/CT has a significant diagnostic value for gynecological malignant tumors and its diagnostic accuracy is better than that of MRI,and can be used as a main imaging method for the diagnosis of gynecological malignant tumors.

引文

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