润燥止痒胶囊联合氯雷他定治疗慢性湿疹的临床疗效
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摘要
目的探讨运用润燥止痒胶囊+氯雷他定治疗慢性湿疹的价值。方法选取东莞市常平镇社区卫生服务中心2018年1—9月收治的127例慢性湿疹患者作为研究对象,按照随机数字表法分为两组,研究组65例采用润燥止痒胶囊+氯雷他定,对照组62例采用氯雷他定,比较两组患者的治疗结果。结果治疗前两组患者临床症状积分比较差异均无统计学意义(均P>0.05),治疗后,研究组各项症状积分均明显低于对照组(均P<0.05);研究组患者不良反应发生率为3.08%,与对照组的6.45%比较差异无统计学意义(P>0.05),但研究组复发率为4.62%,明显低于对照组的16.13%(P<0.05);研究组患者治疗的总有效率为92.31%,明显高于对照组的82.26%(P<0.05)。结论润燥止痒胶囊联合氯雷他定应用于慢性湿疹中效果显著,可有效减轻相关症状,且安全性较高。
Objective To study the application value of Runzao Zhiyang Capsules(润燥止痒胶囊) combined with loratadine in the treatment of chronic eczema. Methods A total of 127 chronic eczema patients treated from January 2018 to September 2018 in Changping Town Community Health Service Center were selected and assigned to study group(n=65) and control group(n=62) according to the random number table. The study group was treated with Runzao Zhiyang Capsules combined with loratadine; the control group was treated with loratadine. The therapeutic effect was compared. Results There was no significant difference in clinical symptom scores between the two groups before treatment(P>0.05). After treatment, the symptom scores of the study group were significantly lower than those of the control group(P<0.05). The incidence of adverse reactions in the study group was 3.08%, and there was no significant difference between the study group and the control group(6.45%)(P>0.05), but the recurrence rate in the study group was 4.62%, which was significantly lower than that in the control group(16.13%)(P<0.05). The total effective rate of the study group was 92.31%, which was significantly higher than that of the control group(82.26%)(P<0.05). Conclusion Runzao Zhiyang Capsules combined with loratadine in the treatment of chronic eczema has significant effects, and can effectively alleviate the related symptoms, and has high safety.
Objective To study the application value of Runzao Zhiyang Capsules(润燥止痒胶囊) combined with loratadine in the treatment of chronic eczema. Methods A total of 127 chronic eczema patients treated from January 2018 to September 2018 in Changping Town Community Health Service Center were selected and assigned to study group(n=65) and control group(n=62) according to the random number table. The study group was treated with Runzao Zhiyang Capsules combined with loratadine; the control group was treated with loratadine. The therapeutic effect was compared. Results There was no significant difference in clinical symptom scores between the two groups before treatment(P>0.05). After treatment, the symptom scores of the study group were significantly lower than those of the control group(P<0.05). The incidence of adverse reactions in the study group was 3.08%, and there was no significant difference between the study group and the control group(6.45%)(P>0.05), but the recurrence rate in the study group was 4.62%, which was significantly lower than that in the control group(16.13%)(P<0.05). The total effective rate of the study group was 92.31%, which was significantly higher than that of the control group(82.26%)(P<0.05). Conclusion Runzao Zhiyang Capsules combined with loratadine in the treatment of chronic eczema has significant effects, and can effectively alleviate the related symptoms, and has high safety.
引文
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[5]李奇俊,马军党.润燥止痒胶囊联合氯雷他定对慢性湿疹患者应激反应、炎症反应的影响[J].陕西中医, 2018, 39(10):1447-1449.
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[2]雷雅丽.氯雷他定治疗面部慢性湿疹临床疗效及安全性分析[J].中国中西医结合皮肤性病学杂志, 2016, 15(2):106-108.
[3]李鹏,闫燕.氯雷他定与无极膏治疗小儿外耳湿疹疗效观察[J].中国药师, 2016, 19(7):1314-1316.
[4]宋业专,卢润超,卢华昌,等.润燥止痒胶囊联合依匹斯汀治疗慢性湿疹疗效及对外周血EOS、血清IgE水平的影响[J].现代中西医结合杂志, 2016, 25(30):3390-3392.
[5]李奇俊,马军党.润燥止痒胶囊联合氯雷他定对慢性湿疹患者应激反应、炎症反应的影响[J].陕西中医, 2018, 39(10):1447-1449.
[6]张学军.皮肤性病学[M]. 7版.北京:人民卫生出版社, 2012.
[7]程非洲,叶红.中西医结合治疗慢性湿疹临床观察[J].实用中医药杂志, 2017, 33(6):673.
[8]中华人民共和国国家中医药管理局.中国病症诊断疗效标准[M].南京:南京大学出版社, 1994.
[9]王肖.润燥止痒胶囊联合依匹斯汀胶囊治疗慢性湿疹疗效观察[J].四川医学, 2015,36(7):1008-1009, 1010.
[10]刘拥军,王丽凌,吴楷,等.润燥止痒胶囊联合湿润烧伤膏治疗血虚风燥型湿疹的临床疗效观察[J].中国烧伤创疡杂志, 2015,27(5):377-379.
[11]陈静思,罗晓燕,王华,等.疱疹性湿疹发病机制的研究进展[J].国际皮肤性病学杂志, 2015, 41(1):25-27.
[12]姜艳.复方甘草酸苷片联合氯雷他定片治疗慢性湿疹的疗效观察[J].中国医院用药评价与分析, 2015, 15(11):1457-1459.
[13]景红梅.中西医结合治疗慢性湿疹45例[J].中国卫生标准管理, 2015, 6(31):114-115.
[14]蒲欣欣.润燥止痒胶囊治疗慢性湿疹的效果研究[J].中国卫生标准管理, 2016, 7(11):144-145.
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