凋亡抑制蛋白XIAP在急性白血病患者中的表达及临床意义
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摘要
目的:探讨凋亡抑制蛋白XIAP(X-linked inhibitor of apoptosis protein)在急性白血病患者中的表达及其临床意义。方法:酶联免疫吸附法检测64例急性白血病患者血清XIAP水平。结果:初发急性白血病患者血清XIAP水平明显高于正常对照组及完全缓解组(P <0. 05),未缓解和复发患者XIAP水平与初诊患者无明显差异(P> 0. 05)。结论:XIAP水平的变化有助于急性白血病病情及疗效的判断,可作为急性白血病疗效观察的一个新指标。
Objective: To investigate the expression and clinical significance of XIAP in patients with acute leukemia. Methods: Serum XIAP levels of acute leukemia patients were determined by enzyme-linked immunosorbent assay. Results: The serum levels of XIAP in initial patient with acute leukemia was significantly higher than that of control and the complete remission group( P < 0. 05),there was no difference in the level of XIAP between nonremission and relapse and initial patients( P > 0. 05). Conclusion: Serum levels of XIAP in the patients with acute leukemia is useful marker to judge state of illness,and XIAP may be regarded as a new indicator for the curative effect of acute leukemia.
Objective: To investigate the expression and clinical significance of XIAP in patients with acute leukemia. Methods: Serum XIAP levels of acute leukemia patients were determined by enzyme-linked immunosorbent assay. Results: The serum levels of XIAP in initial patient with acute leukemia was significantly higher than that of control and the complete remission group( P < 0. 05),there was no difference in the level of XIAP between nonremission and relapse and initial patients( P > 0. 05). Conclusion: Serum levels of XIAP in the patients with acute leukemia is useful marker to judge state of illness,and XIAP may be regarded as a new indicator for the curative effect of acute leukemia.
引文
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[5]Xiong Z,Fu Z,Shi J,et al.Htr A1 down-regulation induces cisplatin resistance in colon cancer by increasing XIAP and activating PI3K/Akt pathway[J].Annals of Clinical&Laboratory Science,2017,47(3):264-270.
[6]Peter Listen,Natalie Roy,Katsuyuki Tamai,et al.Suppression of apoptosis in mammalian cells by NAIP and a related family of IAPgenes[J].Nature,1996,379:349-353.
[7]Chellapandian D,Krueger J,Schechter T,et al.Successful allogeneic hematopoietic stem cell transplantation in XIAP deficiency using reduced-intensity conditioning[J].Pediatric Blood&Cancer,2016,63(2):355-357.
[8]Chessari G,Buck IM,Day JEH,et al.Fragment-based drug discovery targeting inhibitor of apoptosis proteins:Discovery of a nonalanine lead series with dual activity against c IAP1 and XIAP[J].Journal of Medicinal Chemistry,2015,58(16):6574-6588.
[9]Checinska A,Hoogeland BSJ,Rodriguez JA,et al.Role of XIAP in inhibiting cisplatin-induced caspase activation in non-small cell lung cancer cells[J].Experimental Cell Research,2016,313(6):1215-1224.
[10]Zhao C,Zhao Q,Zhang C,et al.miR-15b-5p resensitizes colon cancer cells to 5-fluorouracil by promoting apoptosis via the NF-κB/XIAP axis[J].Scientific Reports,2017,7(1):4194-4196.
[11]Pazhang Y,Jaliani HZ,Imani M,et al.Synergism between NF-kappa B inhibitor,celastrol,and XIAP inhibitor,embelin,in an acute myeloid leukemia cell line,HL-60[J].Journal of Cancer Research&Therapeutics,2016,12(1):155-157.
[12]Gu L,Zhang H,Liu T,et al.Discovery of dual inhibitors of MDM2and XIAP for cancer treatment[J].Cancer Cell,2016,30(4):623-636.
[13]Cesa LC,Shao H,Srinivasan SR,et al.X-linked inhibitor of apoptosis protein(XIAP)is a client of heat shock protein 70(Hsp70)and a biomarker of its inhibition[J].Journal of Biological Chemistry,2018,293(7):2370-2380.
[2]Zhang YP,Qin WW,Ji YR,et al.The roles of Axin1 and Axin2gene in acute leukemia[J].Modern Oncology,2017,25(10):1636-1638.[张阳萍,秦炜炜,及月茹,等.Axin1和Axin2基因在急性白血病中的表达及临床意义[J].现代肿瘤医学,2017,25(10):1636-1638.]
[3]Hikami S,Shiozaki A,Kitagawa-Juge M,et al.The role of c IAP1and XIAP in apoptosis induced by tumor necrosis factor alpha in esophageal squamous cell carcinoma cells[J].Digestive Diseases&Sciences,2017,62(3):1-8.
[4]Zhang ZN,Shen T.Blood disease diagnosis and curative standard[M].Beijing:Science Press,2007:131-134.[张之南,沈悌.血液病诊断与疗效标准[M].北京:科学出版社,2007:131-134.]
[5]Xiong Z,Fu Z,Shi J,et al.Htr A1 down-regulation induces cisplatin resistance in colon cancer by increasing XIAP and activating PI3K/Akt pathway[J].Annals of Clinical&Laboratory Science,2017,47(3):264-270.
[6]Peter Listen,Natalie Roy,Katsuyuki Tamai,et al.Suppression of apoptosis in mammalian cells by NAIP and a related family of IAPgenes[J].Nature,1996,379:349-353.
[7]Chellapandian D,Krueger J,Schechter T,et al.Successful allogeneic hematopoietic stem cell transplantation in XIAP deficiency using reduced-intensity conditioning[J].Pediatric Blood&Cancer,2016,63(2):355-357.
[8]Chessari G,Buck IM,Day JEH,et al.Fragment-based drug discovery targeting inhibitor of apoptosis proteins:Discovery of a nonalanine lead series with dual activity against c IAP1 and XIAP[J].Journal of Medicinal Chemistry,2015,58(16):6574-6588.
[9]Checinska A,Hoogeland BSJ,Rodriguez JA,et al.Role of XIAP in inhibiting cisplatin-induced caspase activation in non-small cell lung cancer cells[J].Experimental Cell Research,2016,313(6):1215-1224.
[10]Zhao C,Zhao Q,Zhang C,et al.miR-15b-5p resensitizes colon cancer cells to 5-fluorouracil by promoting apoptosis via the NF-κB/XIAP axis[J].Scientific Reports,2017,7(1):4194-4196.
[11]Pazhang Y,Jaliani HZ,Imani M,et al.Synergism between NF-kappa B inhibitor,celastrol,and XIAP inhibitor,embelin,in an acute myeloid leukemia cell line,HL-60[J].Journal of Cancer Research&Therapeutics,2016,12(1):155-157.
[12]Gu L,Zhang H,Liu T,et al.Discovery of dual inhibitors of MDM2and XIAP for cancer treatment[J].Cancer Cell,2016,30(4):623-636.
[13]Cesa LC,Shao H,Srinivasan SR,et al.X-linked inhibitor of apoptosis protein(XIAP)is a client of heat shock protein 70(Hsp70)and a biomarker of its inhibition[J].Journal of Biological Chemistry,2018,293(7):2370-2380.
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