妊娠期妇女血清铁、血清铁蛋白水平的相关研究

详细信息    查看全文 | 推荐本文 |

英文篇名：The study of serum iron and serum ferritin in pregnant women 作者：罗晓华 ; 史娜 ; 郭晓珮 ; 翟闪闪 ; 潘瓷 ; 王晓辉 英文作者：LUO Xiao Hua;SHI Na;GUO Xiao Pei;ZHAI Shan Shan;PAN Ci;WANG Xiao Hui;Department of Gynaecology and Obstetrics,The Third Affiliated Hospital of Zhengzhou University; 关键词：妊娠期妇女 ; 血清铁 ; 血清铁蛋白 ; 血红蛋白 英文关键词：pregnant women;;serum iron;;serum ferritin;;hemoglobin 中文刊名：YZWS 英文刊名：Chinese Journal of Women and Children Health 机构：郑州大学第三附属医院妇产科; 出版日期：2019-01-20 出版单位：中国妇幼卫生杂志 年：2019 期：v.10 基金：郑州市科技厅项目(CZSYJJ15032) 语种：中文; 页：YZWS201901009 页数：4 CN：01 ISSN：11-5816/R 分类号：40-43

摘要

目的分析妊娠期健康妇女血清铁、血清铁蛋白、血红蛋白在妊娠期的水平及变化规律,并探讨铁缺乏与贫血的关系。方法将于郑州大学第三附属医院定期产检的438名妊娠期健康妇女分别于妊娠早、中、晚期采集空腹静脉血一次,测定其血清铁、血清铁蛋白及血红蛋白水平。结果妊娠期健康妇女早、中、晚期血清铁的水平(95%CI)分别为8. 13～8. 88mmol/L、8. 00～8. 26 mmol/L、7. 68～8. 00 mmol/L,妊娠期健康妇女早、中、晚期血清铁蛋白的水平(95%CI)分别为44. 78～65. 16μg/L、24. 14～31. 11μg/L、13. 29～16. 38μg/L,妊娠期健康妇女早、中、晚期血红蛋白的水平(95%CI)分别为124. 48～129. 29 g/L、121. 66～125. 26 g/L、119. 34～124. 26 g/L。妊娠期健康妇女血清铁、血清铁蛋白、血红蛋白水平随着妊娠孕周的增加逐渐降低。438例妊娠期健康妇女在妊娠过程中有121例(27. 6%)发生了铁缺乏,其中贫血者64例(52. 9%);机体铁正常的孕妇318例(72. 4%)中有43例(13. 5%)发生了贫血,两组比较差异有统计学意义。结论分析妊娠期妇女铁水平变化,并研究铁缺乏与贫血的关系,可了解妊娠期妇女机体铁的水平状态,用于指导妊娠期铁的补充,降低贫血及其他铁相关疾病的发生率。
        Objective To Analysis the levels and changes of serum iron、serum ferritin and hemoglobin of pregnant women,and explore the relationship between iron deficiency and anemia Methods The fasting venous blood samples were collected from 438 healthy pregnant women during early pregnancy period,middle pregnancy period and late pregnancy period. The levels of serum iron,serum ferritin and hemoglobin were measured. Results The serum iron levels(95% confidence interval) in different pregnancy periods were8. 13-8. 88 mmol/L,8. 00-8. 26 mmol/L and 7. 68-8. 00 mmol/L,respectively. The serum ferritin levels(95% confidence interval) in different pregnancy periods were 44. 78-65. 16 ug/L,24. 14-31. 11 ug/L and 13. 29-16. 38 ug/L,respectively. The hemoglobin levels(95% confidence interval) in different pregnancy periods were 124. 48-129. 29 g/L,121. 66-125. 26 g/L and 119. 34-124,respectively. 26 g/L. There were 121(27. 6%) pregnant women with iron deficiency,including 64(52. 9%) anemic pregnant women.There were 318(72. 4%) pregnant women without iron deficiency,including 43(13. 5%) anemic pregnant women. The differences between two groups had statistical significance. Conclusion By analyzing the changes of serum iron,serum ferritin and hemoglobin of pregnant women,we could know the relationship between iron deficiency and anemic,complement iron reasonably during pregnancy,and reduce the occurrence of iron-related diseases.

引文

[1]李佳蔚,张清友,高洁,等.血清铁在鉴别儿童血管迷走性晕厥和体位性心动过速综合征中的意义[J].北京大学学报(医学版),2013,45(06):923-927.
    [2] Wei Wang,Mary Ann Knovich,Lan G Coffman,et al.Serum ferritin:Past,present and future[J]. BBAGeneral Subjects,2010,1800(8):760-769.
    [3]罗晓丽,杨侃,孙明.老年男性代谢综合征患者血清铁蛋白增高[J].中华高血压杂志,2008,16(07):640-642.
    [4]孙晓燕,黄醒华.妊娠期母体高浓度血红蛋白对妊娠结局的影响及其与补铁的关系[J].中华围产医学杂志,2006(03):204-207.
    [5]张微惠,徐建民,周丽银.血清铁蛋白在不同孕期妊娠妇女检测的临床意义[J].中国实用医药,2017,12(06):45-47.
    [6]张艳.妊娠妇女在不同孕期血清叶酸、维生素B12和血清铁蛋白联合检测及其临床意义[J].中外医学研究,2014,12(31):86-88.
    [7]袁选波.妊娠妇女不同孕期血清叶酸、维生素B12和铁蛋白检测价值[J].当代医学,2018(02):98-99.
    [8]张雪琳.桂林市健康妊娠期妇女红细胞参数参考区间的调查[J].检验医学与临床,2013,10(18):2447-2448.
    [9]屈煜,陈虹,钟惠珍.孕妇铁缺乏早期指标及干预措施的研究[J].中国妇幼保健,2006,21(5):624
    [10]徐湘,朱晓巍,蒋艳敏,等. 2748例住院孕妇妊娠期糖尿病发病率及危险因素的研究[J].南京医科大学学报(自然科学版),2015,35(05):695-698.
    [11]张玲,王丽君.孕中期妊娠期糖尿病孕妇血清铁、锌和铁蛋白的变化情况及其与糖代谢指标的相关性[J].中国现代医学杂志,2017,27(10):71-75.