甘草水提液浓缩过程动态仿真模拟研究
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摘要
目的以甘草提取液浓缩过程为研究对象,采用实验分析与理论模拟相结合的方式,构建了中药浓缩动态仿真模拟过程,为中药浓缩生产过程的工艺研究与设备研发提供了模型支持与理论基础。方法采用动态法测定,得到了不同质量分数下甘草溶液沸点-饱和蒸气压的对应关系,将其代入非随机双液体理论模型方程拟合得到相关活度系数;在此基础上,采用ASPENPLUS构建了甘草水提液浓缩模拟流程;根据动态过程的仿真模拟探讨了在外热式浓缩设备中,加热功率、进料速率和真空度等工艺参数对甘草溶液浓缩过程的影响,并构建了浓缩时间与加热功率的函数方程。结果参数拟合结果为Aij=1.63、Aji=2.32、Bij=336.38、Bji=792.00、Cij=0.5;浓缩时间与加热功率的函数方程为t=2 329 c1H/c0Q。结论以相关实验数据通过热力学模型拟合得到了其相关方程参数。在理想工艺条件下,通过动态仿真模拟对甘草浓缩过程的影响因素进行分析,得出加热功率是影响浓缩过程的关键因素,浓缩时间随加热功率的增加而逐渐降低,但两者所构成的函数关系是非线性的。同时,该函数方程可对中药浓缩时间进行大致预测。这在一定程度上,填补了化工热力学相关理论研究和数据的空白,为中药浓缩生产过程的工艺研究与设备研发提供了理论支持。
Objective Taking the concentration process of liquorice extract as the research object,the dynamic simulation process of concentration of Chinese materia medica(CMM) was constructed by combining experimental analysis with theoretical simulation,which provided the model support and theoretical analysis basis for the process research and equipment development of concentration process of CMM.Methods The corresponding relationship between boiling point and saturated vapor pressure of liquorice solution was determined by dynamic method.The experimental data were fitted by thermodynamic model to obtain relevant parameters.On this basis,the simulation process of liquorice water extract concentration was constructed by using ASPEN PLUS.According to the simulation of dynamic process,the effects of heating power,feed rate,and vacuum degree on liquorice solution concentration process in an external thermal concentrator were discussed.Finally,the equations about concentration time and heating power were obtained by simulation.Results The results of parameter fitting were Aij = 1.63,Aji = 2.32,Bij = 336.38,Bji = 792.00,and Cij = 0.5.Finally,the functional equation for the concentration time and heating power was t = 2 329 c1 H/c0 Q.Conclusion In this study,the effects of different process parameters on the concentration process of TCM were analyzed by simulation and related theories,and a simple prediction of the concentration process was realized.It also perfected and optimized the process simulation data,filled the relevant scientific research gap,and was of great significance to industrial guidance.Firstly,the relevant experimental data was obtained by fitting the thermodynamic model with the relevant experimental data.Then,under the ideal process conditions,the influencing factors of liquorice concentration process were analyzed and discussed by dynamic simulation.It was concluded that heating power was the key factor affecting the concentration process,and the concentration time gradually decreased with the increase of heating power.However,their functional relationship was non-linear.At the same time,the functional equation can be used to roughly predict the concentration time of CMM.To a certain extent,this fills in the gap between the related theoretical research and data of chemical thermodynamics,which provides theoretical support for the process research and equipment development of the concentration process of CMM.
Objective Taking the concentration process of liquorice extract as the research object,the dynamic simulation process of concentration of Chinese materia medica(CMM) was constructed by combining experimental analysis with theoretical simulation,which provided the model support and theoretical analysis basis for the process research and equipment development of concentration process of CMM.Methods The corresponding relationship between boiling point and saturated vapor pressure of liquorice solution was determined by dynamic method.The experimental data were fitted by thermodynamic model to obtain relevant parameters.On this basis,the simulation process of liquorice water extract concentration was constructed by using ASPEN PLUS.According to the simulation of dynamic process,the effects of heating power,feed rate,and vacuum degree on liquorice solution concentration process in an external thermal concentrator were discussed.Finally,the equations about concentration time and heating power were obtained by simulation.Results The results of parameter fitting were Aij = 1.63,Aji = 2.32,Bij = 336.38,Bji = 792.00,and Cij = 0.5.Finally,the functional equation for the concentration time and heating power was t = 2 329 c1 H/c0 Q.Conclusion In this study,the effects of different process parameters on the concentration process of TCM were analyzed by simulation and related theories,and a simple prediction of the concentration process was realized.It also perfected and optimized the process simulation data,filled the relevant scientific research gap,and was of great significance to industrial guidance.Firstly,the relevant experimental data was obtained by fitting the thermodynamic model with the relevant experimental data.Then,under the ideal process conditions,the influencing factors of liquorice concentration process were analyzed and discussed by dynamic simulation.It was concluded that heating power was the key factor affecting the concentration process,and the concentration time gradually decreased with the increase of heating power.However,their functional relationship was non-linear.At the same time,the functional equation can be used to roughly predict the concentration time of CMM.To a certain extent,this fills in the gap between the related theoretical research and data of chemical thermodynamics,which provides theoretical support for the process research and equipment development of the concentration process of CMM.
引文
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[15]伍振峰,罗晶,万娜,等.中药减压提取沸点与饱和蒸气压关系影响因素研究[J].中草药,2016,47(23):4166-4172.
[16]金珊,孙杰,金申.对氨基苯酚-乙醇/水复合溶剂体系饱和蒸汽压的测定和关联[J].石化技术与应用,2011,29(6):513-515.
[2]刘明言,余根,王红.中药提取液浓缩新工艺和新技术进展[J].中国畜牧兽医文摘,2006,31(6):184-187.
[3]李宏伟,李宏亮.中药提取中真空浓缩设备的自动化研究[J].今日科苑,2007(12):120.
[4]陈远琪,李胜勇.中药浓缩工艺分析与控制系统设计[J].机械与电子,2012,34(6):31-34.
[5]张立国,朱静,倪力军.中药提取和浓缩过程的理论模型及控制策略[J].天津大学学报:自然科学与工程技术版,2007,40(12):1490-1494.
[6]中国药典[S].一部.2015.
[7]于洋,司梦兰,高雪地,等.MVR技术在中药浓缩过程中节能优化的仿真研究[J].中国医药工业杂志,2017,48(11):1610-1616.
[8]于洋,侯一哲,余河水,等.甘草酸溶液浓缩过程中浓度-沸点-饱和蒸汽压三者关系研究[J].中草药,2018,49(1):142-150.
[9]于洋,所同川,李正,等.一种中药提取液动态沸点#饱和蒸汽压测定仪:中国,CN107436273A[P].2017-12-05.
[10]鲍祁,崔志娱,高大泉,等.含盐异丙醇溶液饱和蒸汽压的测定和关联[J].化工学报,1990(3):382-385.
[11]上海化工学院化学工程专业,上海石油化学研究所.醋酸-水-醋酸乙烯酯三元系气液平衡的研究--I.液相完全互溶区[J].化学学报,1976,67(2):79-93.
[12]Wang H X,Suo T C,Wu X L,et al.Near infrared spectroscopy based monitoring of extraction processes of raw material with the help of dynamic predictive modeling[J].Spectrochim Acta A:Mol Biomol Spectrosc,2017,192:222-227.
[13]Suo T C,Wang H X,Shi X J,et al.Combining near infrared spectroscopy with predictive model and expertise to monitor herb extraction processes[J].J Pharm Biomed Anal,2018,148:214-223.
[14]李薇,宋新波,孙成荣,等.三个不同品种甘草多糖的含量测定[J].天津中医药,2013,30(1):47-49.
[15]伍振峰,罗晶,万娜,等.中药减压提取沸点与饱和蒸气压关系影响因素研究[J].中草药,2016,47(23):4166-4172.
[16]金珊,孙杰,金申.对氨基苯酚-乙醇/水复合溶剂体系饱和蒸汽压的测定和关联[J].石化技术与应用,2011,29(6):513-515.
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