紫胶树脂铵盐为壁材的微胶囊制备及性能研究
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摘要
以紫胶树脂铵盐为壁材,红霉素为芯材,采用乳化-固化法制备了红霉素-紫胶树脂铵盐微胶囊,采用SEM、DSC、FTIR进行形貌和结构表征。结果表明,以紫胶树脂铵盐为壁材的微球表面光滑致密、形态圆整,粒度分布较为均匀,酸化过程中部分紫胶树脂铵盐在微球表面析出,形成致密的树脂膜对芯材起到良好的保护作用,且芯材与壁材并没有发生化学反应。对微胶囊载药率和模拟条件下体胃和体肠环境目标药物释放特性的研究表明,微胶囊载药率为1. 19%,在模拟体胃环境中,70 min内,红霉素释放量仅为载药率的2. 07%;模拟体肠环境中,微胶囊能够在10～120 min内实现红霉素药物的均匀释放,累积释放量达到79. 75%。可见,紫胶树脂铵盐在亲水性肠溶性药物包衣材料中有较强的应用潜力和价值。
Emulsification-solidification method was employed to fabricate the microcapsules take erythromycin as core and shellac ammonium salt as wall materials. The characterization of morphology and structure for microcapsules was processed by SEM,DSC and FTIR. The result showed that the size of microcapsule distributed uniformly and the surface of microcapsule was smooth and dense. In the acidification,sectional shellac ammonium salt precipitated from microcapsules. A layer of dense shellac film was formed in the surfaces of microcapsules and core materials were protected greatly. Obviously,it was not happened that chemical reaction between core and wall materials. And then,the release features of microcapsules in the simulative stomach and intestine were investigated successfully. The results showed that the loading efficiency of microcapsules was 1. 19%. Under simulative stomach condition,the release amount of erythromycin was only 2. 07% in 70 min. Moreover,the accumulative release of erythromycin from microcapsules was homogeneous at 10 ～ 120 min in the simulative intestine condition,and the accumulative release amount achieved 79. 75%. In a word,all the results showed that shellac ammonium salt was a good choice for hydrophilic enteric solubility coating material and worth be researched for further step in the future.
Emulsification-solidification method was employed to fabricate the microcapsules take erythromycin as core and shellac ammonium salt as wall materials. The characterization of morphology and structure for microcapsules was processed by SEM,DSC and FTIR. The result showed that the size of microcapsule distributed uniformly and the surface of microcapsule was smooth and dense. In the acidification,sectional shellac ammonium salt precipitated from microcapsules. A layer of dense shellac film was formed in the surfaces of microcapsules and core materials were protected greatly. Obviously,it was not happened that chemical reaction between core and wall materials. And then,the release features of microcapsules in the simulative stomach and intestine were investigated successfully. The results showed that the loading efficiency of microcapsules was 1. 19%. Under simulative stomach condition,the release amount of erythromycin was only 2. 07% in 70 min. Moreover,the accumulative release of erythromycin from microcapsules was homogeneous at 10 ～ 120 min in the simulative intestine condition,and the accumulative release amount achieved 79. 75%. In a word,all the results showed that shellac ammonium salt was a good choice for hydrophilic enteric solubility coating material and worth be researched for further step in the future.
引文
[1] Ansari M F,Sarkhel G. Improving coating properties of shellac-epoxidised-novolac blends with melamine formaldehyde resin[J]. Pigment&Resin Technology,2017,46(2):92-99.
[2] Kumar V,Gupta S,Mishra N K,et al. Laser-induced fabrication of gold nanoparticles on shellac-driven peptide nanostructures[J]. Materials Research Express,2017,4(3):35-36.
[3]于连松,张弘,郑华,等.响应曲面法漂白紫胶微波-真空干燥工艺研究[[J].应用化工,2012,41(1):37-43.
[4] Luo Q M,Li K,Xu J,et al. A novel biobased sodium shellac for wrapping disperse multi-scale emulsion particles[J]. Journal of Agricultural and Food Chemistry,2016,64(49):9374-9380.
[5] Chitravathi K,Chauhan O P,Raju P S,et al. Shelf life extension of green chillies(Capsicum annuum L.)using shellac-based surface coating in combination with modified atmosphere packaging[J]. Journal of Food Science&Technology,2016,53(8):1-9.
[6] Ma K,Qiu Y,Fu Y,et al. Improved shellac mediated nanoscale application drug release effect in a gastric-site drug delivery system[J]. Rsc Advances,2017,7(84):53401-53406.
[7] Phaechamud T,Mahadlek J,Chuenbarn T. In situ forming gel comprising bleached shellac loaded with antimicrobial drugs for periodontitis treatment[J]. Materials&Design,2016,89:294-303.
[8] Limmatvapirat S,Limmatvapirat C,Puttipipatkhachorn S,et al. Modulation of drug release kinetics of shellac-based matrix tables by in-situ polymerization through annealing process[J]. European Journal of Pharmaceutics and Biopharmaceutics,2008,69(3):1004-1013.
[9] Dey R K,Tiwary G S,Patnaik T,et al. Shellac-polyamidoamine:Design of a new polymeric carrier material for controlled release application[J]. Journal of Applied Polymer Science,2012,125(4):2626-2635.
[10]杜德才.肠熔包衣材料在药物制剂中的应用[J].中国药业,2001,10(5):62-63.
[11]李凯,周梅村,张弘,等.漂白紫胶水溶胶的制备[J].食品科学,2009,30(18):142-147.
[12] Limmatvapirat S,Limmatvapirat C,Luangtanaanan M,et al. Modification of physicochemical and mechanical properties of shellac by partial hydrolysis[J]. International Journal of Pharmaceutics,2004,278:41-49.
[13] Limmatvapirat S,Limmatvapirat C,Puttipipatkhachorn S,et al. Enhanced enteric properties and stability of shellac films through composite salts formation[J]. European Journal of Pharmaceutics and Biopharmaceutics,2007,67(3):690-698.
[14]李凯,周梅村,张弘,等.紫胶树脂溶解性及其钠盐的理化性质[J].食品科学,2010,31(21):159-164.
[15]陈奇,张弘,郑华,等.紫胶树脂在氨水中的溶解性及其铵盐的理化性质[J].食品科学,2013,34(23):77-82.
[16] Li K,Zheng H,Zhang H,et al. A novel approach to the fabrication of bleached shellac by a totally chlorine-free(TCF)bleaching method[J]. RSC Advances,2016(6):55618-55625.
[17] Li T,Yang F,Dian S N,et al. Preparation conditions of erythromycin gelatin microspheres[J]. Journal of Clinical Rehabilitative Tissue Engineering Research,2008(12):8179-8182.
[18]孙华燕,徐风华,郭代红.紫外分光光度法测定创伤敷料中红霉素的含量[J].中国药师,2008(6):622-623.
[19]何丽明,张慧文,曾晓晖.紫外分光光度法测定罗红霉素胶囊的含量[J].广东药学院学报,2004(5):475-477.
[20]国家药典委员会.中国药典2010版:二部[M].北京:中国医药科技出版社,2010.
[2] Kumar V,Gupta S,Mishra N K,et al. Laser-induced fabrication of gold nanoparticles on shellac-driven peptide nanostructures[J]. Materials Research Express,2017,4(3):35-36.
[3]于连松,张弘,郑华,等.响应曲面法漂白紫胶微波-真空干燥工艺研究[[J].应用化工,2012,41(1):37-43.
[4] Luo Q M,Li K,Xu J,et al. A novel biobased sodium shellac for wrapping disperse multi-scale emulsion particles[J]. Journal of Agricultural and Food Chemistry,2016,64(49):9374-9380.
[5] Chitravathi K,Chauhan O P,Raju P S,et al. Shelf life extension of green chillies(Capsicum annuum L.)using shellac-based surface coating in combination with modified atmosphere packaging[J]. Journal of Food Science&Technology,2016,53(8):1-9.
[6] Ma K,Qiu Y,Fu Y,et al. Improved shellac mediated nanoscale application drug release effect in a gastric-site drug delivery system[J]. Rsc Advances,2017,7(84):53401-53406.
[7] Phaechamud T,Mahadlek J,Chuenbarn T. In situ forming gel comprising bleached shellac loaded with antimicrobial drugs for periodontitis treatment[J]. Materials&Design,2016,89:294-303.
[8] Limmatvapirat S,Limmatvapirat C,Puttipipatkhachorn S,et al. Modulation of drug release kinetics of shellac-based matrix tables by in-situ polymerization through annealing process[J]. European Journal of Pharmaceutics and Biopharmaceutics,2008,69(3):1004-1013.
[9] Dey R K,Tiwary G S,Patnaik T,et al. Shellac-polyamidoamine:Design of a new polymeric carrier material for controlled release application[J]. Journal of Applied Polymer Science,2012,125(4):2626-2635.
[10]杜德才.肠熔包衣材料在药物制剂中的应用[J].中国药业,2001,10(5):62-63.
[11]李凯,周梅村,张弘,等.漂白紫胶水溶胶的制备[J].食品科学,2009,30(18):142-147.
[12] Limmatvapirat S,Limmatvapirat C,Luangtanaanan M,et al. Modification of physicochemical and mechanical properties of shellac by partial hydrolysis[J]. International Journal of Pharmaceutics,2004,278:41-49.
[13] Limmatvapirat S,Limmatvapirat C,Puttipipatkhachorn S,et al. Enhanced enteric properties and stability of shellac films through composite salts formation[J]. European Journal of Pharmaceutics and Biopharmaceutics,2007,67(3):690-698.
[14]李凯,周梅村,张弘,等.紫胶树脂溶解性及其钠盐的理化性质[J].食品科学,2010,31(21):159-164.
[15]陈奇,张弘,郑华,等.紫胶树脂在氨水中的溶解性及其铵盐的理化性质[J].食品科学,2013,34(23):77-82.
[16] Li K,Zheng H,Zhang H,et al. A novel approach to the fabrication of bleached shellac by a totally chlorine-free(TCF)bleaching method[J]. RSC Advances,2016(6):55618-55625.
[17] Li T,Yang F,Dian S N,et al. Preparation conditions of erythromycin gelatin microspheres[J]. Journal of Clinical Rehabilitative Tissue Engineering Research,2008(12):8179-8182.
[18]孙华燕,徐风华,郭代红.紫外分光光度法测定创伤敷料中红霉素的含量[J].中国药师,2008(6):622-623.
[19]何丽明,张慧文,曾晓晖.紫外分光光度法测定罗红霉素胶囊的含量[J].广东药学院学报,2004(5):475-477.
[20]国家药典委员会.中国药典2010版:二部[M].北京:中国医药科技出版社,2010.
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