芪术茯苓汤治疗恶性肿瘤化疗后白细胞减少临床研究
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摘要
目的:研究芪术茯苓汤治疗恶性肿瘤化疗后白细胞减少的临床疗效。方法:回顾分析156例恶性肿瘤化疗后白细胞减少患者临床资料,随机分为对照组和观察组各78例。对照组给予利可君片治疗,观察组在对照组基础上采用芪术茯苓汤治疗,连续治疗4个疗程(1个疗程7d)后,观察对比临床治疗有效率、临床症状改善以及不良反应。结果:观察组总有效率83.33%高于对照组51.28%(P<0.05);治疗后两组白细胞计数(WBC)、中性粒细胞计数(NE)、血红蛋白浓度(HGB)、血小板计数(PLT)均升高,与治疗前对比(P<0.05),且观察组升高优于对照组(P<0.05);治疗后两组临床症状(乏力、头晕、食欲减退、四肢酸软)评分降低,与治疗前对比(P<0.05),且观察组改善优于对照组(P<0.05);观察组临床不良反应发生率与对照组对比(P>0.05)。结论:芪术茯苓汤治疗恶性肿瘤化疗后白细胞减少疗效确切,可促进白细胞计数升高,增强免疫功能,值得临床应用。
Objective:To study the clinical curative effect of Qizhu Fuling decoction in the treatment of malignant tumor leukopenia after chemotherapy.Methods:A retrospective analysis 156 cases of malignant tumor leukopenia after chemotherapy in patients with clinical data,were randomly divided into control group and observation group,78 patients in each group.The control group the Leucogen tablets treatment,patients in the observation group in the control group based on the use of Qizhu Fuling decoction treatment,continuous treatment of 4 courses(1 sessions 7 d),compare the clinical curative effect.Results:The total efficiency of 83.33%in observation group was significantly higher than the control group 51.28%(P< 0.05);2 groups of white blood cell count after the treatment(WBC),neutrophil count(NE),hemoglobin concentration(HGB),platelet count(PLT)were significantly increased,compared with before treatment(P<0.05),and the observation group increased significantly than those in the control group(P< 0.05)after treatment;2 groups of patients with clinical symptoms(fatigue,dizziness,loss of appetite,aching and limp)was significantly reduced,compared with before treatment(P<0.05),and the observation group improved significantly better than the control group(P<0.05);The incidence of adverse reactions in the observation group was significantly higher than that of the control group(P>0.05).Conclusion:Qizhu Fuling decoction in the treatment of malignant tumor after chemotherapy white blood cell reduction effect is exact,can promote white blood cell count,enhance the immune function,worthy of clinical promotion and application.
Objective:To study the clinical curative effect of Qizhu Fuling decoction in the treatment of malignant tumor leukopenia after chemotherapy.Methods:A retrospective analysis 156 cases of malignant tumor leukopenia after chemotherapy in patients with clinical data,were randomly divided into control group and observation group,78 patients in each group.The control group the Leucogen tablets treatment,patients in the observation group in the control group based on the use of Qizhu Fuling decoction treatment,continuous treatment of 4 courses(1 sessions 7 d),compare the clinical curative effect.Results:The total efficiency of 83.33%in observation group was significantly higher than the control group 51.28%(P< 0.05);2 groups of white blood cell count after the treatment(WBC),neutrophil count(NE),hemoglobin concentration(HGB),platelet count(PLT)were significantly increased,compared with before treatment(P<0.05),and the observation group increased significantly than those in the control group(P< 0.05)after treatment;2 groups of patients with clinical symptoms(fatigue,dizziness,loss of appetite,aching and limp)was significantly reduced,compared with before treatment(P<0.05),and the observation group improved significantly better than the control group(P<0.05);The incidence of adverse reactions in the observation group was significantly higher than that of the control group(P>0.05).Conclusion:Qizhu Fuling decoction in the treatment of malignant tumor after chemotherapy white blood cell reduction effect is exact,can promote white blood cell count,enhance the immune function,worthy of clinical promotion and application.
引文
[1]马晓兰,陶可胜,李静.肿瘤化疗后白细胞减少症的中西医治疗进展[J].中国当代医药,2015,22(1):16-19.
[2]陈水星,陈南,金晓霞.癌症放化疗后白细胞减少症中医治疗八法[J].实用中医内科杂志,2010,24(2):5-7.
[3]孙长侠,孙斐,国凤梅,等.芪术茯苓汤治疗恶性肿瘤化疗后白细胞减少的临床研究[J].辽宁中医杂志,2013,40(6):1167-1168.
[4]何秀丽,黎光强,陈林.中药防治肿瘤放疗化疗后白细胞减少症研究进展[J].亚太传统医药,2014,15(10):33-37.
[5]吕玉敏,胡新华,丁月秀.中西医结合治疗化疗后白细胞减少60例疗效观察[J].中国实用医药,2008,3(12):158-159.
[6]谷雨芳,张映城,施俊,等.复方阿胶浆防治胃癌患者化疗后白细胞减少的临床观察[J].环球中医药,2012,5(8):614-616.
[7]国家食品药品监督管理局.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:109.
[8]苟宇,王军,陈群英.中西药联用治疗化疗后白细胞减少症54例[J].实用中医内科杂志,2003,17(5):395.
[9]张扶莉,杨利生.升白方与黄芪注射液治疗化疗后白细胞减少症疗效观察[J].陕西中医,2011,32(8):1023-1024.
[10]曾小红.黄芪注射液治疗甲巯咪唑引起甲亢患者白细胞减少症评价[J].辽宁中医药大学学报,2014,17(12):176-178.
[11]王慧娟,王晋平,张佳红.联合黄芪注射液治疗系统性红斑狼疮白细胞减少症的临床观察[J].兰州大学学报:医学版,2007,33(1):76-78.
[12]高晓会,刘锋卫,张治业,等.黄芪四物汤加减预防乳腺癌术后化疗白细胞减少的研究[J].中外健康文摘,2011,8(21):991-997.
[13]何燕清,陆桂喜.中药解毒方治疗化疗引起白细胞减少症38例[J].中国药业,2004,13(6):71.
[14]马秀萍,张敏,张亚平.健脾养胃汤治疗化疗后消化道反应64例[J].陕西中医,2013,34(5):539-539.
[15]侯静霞.十全大补汤治疗化疗后白细胞减少症86例[J].陕西中医,2012,33(6):682-683.
[2]陈水星,陈南,金晓霞.癌症放化疗后白细胞减少症中医治疗八法[J].实用中医内科杂志,2010,24(2):5-7.
[3]孙长侠,孙斐,国凤梅,等.芪术茯苓汤治疗恶性肿瘤化疗后白细胞减少的临床研究[J].辽宁中医杂志,2013,40(6):1167-1168.
[4]何秀丽,黎光强,陈林.中药防治肿瘤放疗化疗后白细胞减少症研究进展[J].亚太传统医药,2014,15(10):33-37.
[5]吕玉敏,胡新华,丁月秀.中西医结合治疗化疗后白细胞减少60例疗效观察[J].中国实用医药,2008,3(12):158-159.
[6]谷雨芳,张映城,施俊,等.复方阿胶浆防治胃癌患者化疗后白细胞减少的临床观察[J].环球中医药,2012,5(8):614-616.
[7]国家食品药品监督管理局.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:109.
[8]苟宇,王军,陈群英.中西药联用治疗化疗后白细胞减少症54例[J].实用中医内科杂志,2003,17(5):395.
[9]张扶莉,杨利生.升白方与黄芪注射液治疗化疗后白细胞减少症疗效观察[J].陕西中医,2011,32(8):1023-1024.
[10]曾小红.黄芪注射液治疗甲巯咪唑引起甲亢患者白细胞减少症评价[J].辽宁中医药大学学报,2014,17(12):176-178.
[11]王慧娟,王晋平,张佳红.联合黄芪注射液治疗系统性红斑狼疮白细胞减少症的临床观察[J].兰州大学学报:医学版,2007,33(1):76-78.
[12]高晓会,刘锋卫,张治业,等.黄芪四物汤加减预防乳腺癌术后化疗白细胞减少的研究[J].中外健康文摘,2011,8(21):991-997.
[13]何燕清,陆桂喜.中药解毒方治疗化疗引起白细胞减少症38例[J].中国药业,2004,13(6):71.
[14]马秀萍,张敏,张亚平.健脾养胃汤治疗化疗后消化道反应64例[J].陕西中医,2013,34(5):539-539.
[15]侯静霞.十全大补汤治疗化疗后白细胞减少症86例[J].陕西中医,2012,33(6):682-683.
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