微等离子束联合夫西地酸乳膏治疗凹陷性痤疮瘢痕的美容效果研究
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摘要
目的:观察微等离子束联合夫西地酸乳膏治疗凹陷性痤疮瘢痕的临床疗效及对皮肤美容效果的影响。方法:选择笔者医院2016年2月-2017年1月收治的凹陷性痤疮瘢痕患者240例,采用数字随机表法分为对照组和观察组,每组120例。对照组仅采用夫西地酸乳膏治疗至结痂脱落,观察组在采用夫西地酸乳膏治疗的基础上,再予以微等离子束治疗,治疗3次为1个疗程。收集并比较两组患者治疗过程中或完成治疗后的不良反应。采用ECCA权重评分表对两组患者瘢痕进行定性定量评价,并进行治疗前后组内、治疗后组间比较,计算疗效指数,综合评定治疗方案对患者瘢痕皮肤的美容效果。结果:对照组15例患者治疗过程中及完成治疗后出现不良反应,不良反应发生率为12.50%;观察组19例出现不良反应,不良反应发生率为15.83%,两组患者不良反应率比较,差异无统计学意义(P>0.05)。两组患者治疗后ECCA瘢痕评分均较治疗前明显降低,且观察组明显低于对照组(P<0.05)。观察组治疗指数及临床总有效率明显高于对照组,差异有统计学意义(P<0.05)。结论:微等离子束联合夫西地酸乳膏治疗凹陷性痤疮瘢痕有较好疗效,可提升皮肤美容效果,且不良反应率低,安全高效,具有较高的临床价值。
Objective To observe the clinical efficacy of microplasma combined with Fusidic Acid Cream in the treatment of sunken acne scar, and to provide reference for the selection of clinical treatment options for sunken acne scar. Methods 240 patients with concave acne scar treated in our hospital from February 2016 to January 2017 were selected as study subjects. According to the serial number,they were divided into the control group and the observation group, 120 cases in each group. The control group were treated with Fusidic Acid Cream to scab, on the basis of the use of Fusidic Acid Cream treatment,the observation group were,treated wiyh microplasma beam treatment, a total of 3 times for a course of treatment. The adverse reactions of two groups of patients during treatment or after treatment were collected and compared. Two groups of sunken acne scars were evaluated qualitatively and quantitatively with the ECCA weight score table. The results were compared before and after treatment and after treatment. The curative effect index was calculated, and the effect of the treatment scheme on the skin scar skin was evaluated. Results 15 cases of adverse reactions in the control group were 12.50%,19 cases of adverse reactions in the observation group were 15.83%, and there was no significant difference in the rate of adverse reaction between the two groups(P>0.05). After treatment, the ECCA scar scores of the two groups were significantly lower than those before treatment, and the observation group was significantly lower than that of the control group(P<0.05). The therapeutic index of the observation group was significantly higher than that of the control group, and the total effective rate of the observation group was significantly higher than that of the control group(P<0.05). Conclusion microplasma combined with Fusidic Acid Cream can effectively improve the quality and quantity of cicatrix and improve the cosmetic effect of the skin. It does not increase the adverse reaction rate, and it is safe and efficient. It is of high clinical value for the treatment of acne cicatrix with depression.
Objective To observe the clinical efficacy of microplasma combined with Fusidic Acid Cream in the treatment of sunken acne scar, and to provide reference for the selection of clinical treatment options for sunken acne scar. Methods 240 patients with concave acne scar treated in our hospital from February 2016 to January 2017 were selected as study subjects. According to the serial number,they were divided into the control group and the observation group, 120 cases in each group. The control group were treated with Fusidic Acid Cream to scab, on the basis of the use of Fusidic Acid Cream treatment,the observation group were,treated wiyh microplasma beam treatment, a total of 3 times for a course of treatment. The adverse reactions of two groups of patients during treatment or after treatment were collected and compared. Two groups of sunken acne scars were evaluated qualitatively and quantitatively with the ECCA weight score table. The results were compared before and after treatment and after treatment. The curative effect index was calculated, and the effect of the treatment scheme on the skin scar skin was evaluated. Results 15 cases of adverse reactions in the control group were 12.50%,19 cases of adverse reactions in the observation group were 15.83%, and there was no significant difference in the rate of adverse reaction between the two groups(P>0.05). After treatment, the ECCA scar scores of the two groups were significantly lower than those before treatment, and the observation group was significantly lower than that of the control group(P<0.05). The therapeutic index of the observation group was significantly higher than that of the control group, and the total effective rate of the observation group was significantly higher than that of the control group(P<0.05). Conclusion microplasma combined with Fusidic Acid Cream can effectively improve the quality and quantity of cicatrix and improve the cosmetic effect of the skin. It does not increase the adverse reaction rate, and it is safe and efficient. It is of high clinical value for the treatment of acne cicatrix with depression.
引文
[1]俞珊,陈品中,袁冰峰,等.微等离子束联合积雪苷霜软膏治疗凹陷性痤疮瘢痕疗效观察[J].中国美容医学,2016,25(7):69-71.
[2]Elsaie ML,Ibrahim SM,Saudi W.Ablative fractional 10 600 nm carbon dioxide laser versus non-ablative fractional 1 540nm erbium-glass laser in egyptian post-acne scar patients[J].J Lasers Med Sci,2018,9(1):32-35.
[3]俞珊.微等离子束联合积雪苷霜软膏治疗凹陷性痤疮瘢痕疗效观察[D].南京:南京中医药大学,2016.
[4]康小平,董明国,龙飞,等.超脉冲二氧化碳点阵激光治疗对女性凹陷性痤疮瘢痕患者p38MAPK通路蛋白的影响[J].广东医学,2016,37(22):3397-3399.
[5]朱格非,麦慧.点阵铒激光联合bFGF治疗面部凹陷性痤疮瘢痕34例[J].重庆医学,2014,28(1):53-54,57.
[6]Tan J,Bourdès V,Bissonnette R,et al.Prospective study of pathogenesis of atrophicacnescars and role of macular erythema[J].J Drugs Dermatol,2017,16(6):566-572.
[7]皮超,王鸿健,梁瑜珩,等.凹陷性痤疮瘢痕的治疗进展[J].临床皮肤科杂志,2014,43(12):750-752.
[8]赵菊花,苏青,何启敏,等.果酸联合夫西地酸乳膏治疗寻常型痤疮的临床疗效[J].西部医学,2017,29(3):389-392.
[9]Dreno B,Khammari A,Orain N,et al.ECCA grading scale:an original validated acne scar grading scale for clinical practice in dermatology[J].Dermatology,2007,214(1):46-51.
[10]Elsaie ML,Ibrahim SM,Saudi W.Ablative fractional 10 600nm carbon dioxide laser versus non-ablative fractional 1 540nm erbiumglass laser in egyptian post-acne scarpatients[J].J Lasers Med Sci,2018,9(1):32-35.
[11]陈海亭,赵一彧,徐甜甜,等.黄地养阴颗粒联合夫西地酸乳膏及阿达帕林凝胶治疗寻常型痤疮的疗效观察[J].中国中西医结合皮肤性病学杂志,2016,15(3):178-179.
[12]龙剑文,皮先明.体外培育牛黄联合夫西地酸乳膏治疗Ⅲ级寻常性痤疮疗效观察[J].中国美容医学,2015,29(5):55-57.
[13]章晓阳,江建雄,金如钧,等.2%夫西地酸乳膏治疗细菌感染性皮肤病疗效与安全性观察[J].中华医院感染学杂志,2016,26(7):1598-1600.
[14]陈建民,陈红玲,卢晓龙,等.细菌性皮肤感染采用夫西地酸乳膏治疗的临床效果与安全性评价[J].中华医院感染学杂志,2015,30(2):355-356,362.
[15]Benedikt J,Ellerweg D,Von Keudell A.Molecularbeamsampling system with very highbeam-to-background ratio:the rotating skimmer concept[J].Rev Sci Instrum,2009,80(5):055107.
[16]杨剑霞,孙丽凯.复方金银花煎液湿热敷联合夫西地酸乳膏外用治疗分子靶向药物所致皮疹的效果观察[J].护理学报,2015,31(2):61-62.
[17]贺安,谭红.强脉冲光联合夫西地酸乳膏治疗中度痤疮的疗效观察[J].皮肤性病诊疗学杂志,2015,27(4):306-308.
[18]Min S,Yoon JY,Park SY,et al.Combination of platelet rich plasma in fractional carbon dioxide laser treatment increased clinical efficacy of foracnescarby enhancement of collagen production and modulation of laser-induced inflammation[J].Lasers Surg Med,2017,(94)8:217201.
[19]姜鹏爽,石云.夫西地酸乳膏联合多磺酸黏多糖乳膏治疗寻常痤疮疗效观察[J].中国中西医结合皮肤性病学杂志,2017,16(4):318-320.
[20]朱竹青.阿达帕林凝胶联合夫西地酸乳膏治疗轻中度痤疮疗效观察[D].重庆:重庆医科大学,2015.
[2]Elsaie ML,Ibrahim SM,Saudi W.Ablative fractional 10 600 nm carbon dioxide laser versus non-ablative fractional 1 540nm erbium-glass laser in egyptian post-acne scar patients[J].J Lasers Med Sci,2018,9(1):32-35.
[3]俞珊.微等离子束联合积雪苷霜软膏治疗凹陷性痤疮瘢痕疗效观察[D].南京:南京中医药大学,2016.
[4]康小平,董明国,龙飞,等.超脉冲二氧化碳点阵激光治疗对女性凹陷性痤疮瘢痕患者p38MAPK通路蛋白的影响[J].广东医学,2016,37(22):3397-3399.
[5]朱格非,麦慧.点阵铒激光联合bFGF治疗面部凹陷性痤疮瘢痕34例[J].重庆医学,2014,28(1):53-54,57.
[6]Tan J,Bourdès V,Bissonnette R,et al.Prospective study of pathogenesis of atrophicacnescars and role of macular erythema[J].J Drugs Dermatol,2017,16(6):566-572.
[7]皮超,王鸿健,梁瑜珩,等.凹陷性痤疮瘢痕的治疗进展[J].临床皮肤科杂志,2014,43(12):750-752.
[8]赵菊花,苏青,何启敏,等.果酸联合夫西地酸乳膏治疗寻常型痤疮的临床疗效[J].西部医学,2017,29(3):389-392.
[9]Dreno B,Khammari A,Orain N,et al.ECCA grading scale:an original validated acne scar grading scale for clinical practice in dermatology[J].Dermatology,2007,214(1):46-51.
[10]Elsaie ML,Ibrahim SM,Saudi W.Ablative fractional 10 600nm carbon dioxide laser versus non-ablative fractional 1 540nm erbiumglass laser in egyptian post-acne scarpatients[J].J Lasers Med Sci,2018,9(1):32-35.
[11]陈海亭,赵一彧,徐甜甜,等.黄地养阴颗粒联合夫西地酸乳膏及阿达帕林凝胶治疗寻常型痤疮的疗效观察[J].中国中西医结合皮肤性病学杂志,2016,15(3):178-179.
[12]龙剑文,皮先明.体外培育牛黄联合夫西地酸乳膏治疗Ⅲ级寻常性痤疮疗效观察[J].中国美容医学,2015,29(5):55-57.
[13]章晓阳,江建雄,金如钧,等.2%夫西地酸乳膏治疗细菌感染性皮肤病疗效与安全性观察[J].中华医院感染学杂志,2016,26(7):1598-1600.
[14]陈建民,陈红玲,卢晓龙,等.细菌性皮肤感染采用夫西地酸乳膏治疗的临床效果与安全性评价[J].中华医院感染学杂志,2015,30(2):355-356,362.
[15]Benedikt J,Ellerweg D,Von Keudell A.Molecularbeamsampling system with very highbeam-to-background ratio:the rotating skimmer concept[J].Rev Sci Instrum,2009,80(5):055107.
[16]杨剑霞,孙丽凯.复方金银花煎液湿热敷联合夫西地酸乳膏外用治疗分子靶向药物所致皮疹的效果观察[J].护理学报,2015,31(2):61-62.
[17]贺安,谭红.强脉冲光联合夫西地酸乳膏治疗中度痤疮的疗效观察[J].皮肤性病诊疗学杂志,2015,27(4):306-308.
[18]Min S,Yoon JY,Park SY,et al.Combination of platelet rich plasma in fractional carbon dioxide laser treatment increased clinical efficacy of foracnescarby enhancement of collagen production and modulation of laser-induced inflammation[J].Lasers Surg Med,2017,(94)8:217201.
[19]姜鹏爽,石云.夫西地酸乳膏联合多磺酸黏多糖乳膏治疗寻常痤疮疗效观察[J].中国中西医结合皮肤性病学杂志,2017,16(4):318-320.
[20]朱竹青.阿达帕林凝胶联合夫西地酸乳膏治疗轻中度痤疮疗效观察[D].重庆:重庆医科大学,2015.
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