胆道结石动物模型的研究进展
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摘要
胆道结石是常见病,在我国发病率逐年升高,但其机制至今未明。选择和建立理想的动物模型对研究胆道结石形成机制有重要意义。根据目前的胆囊结石形成机制学说,制作胆道结石动物模型有不同方法。建立高效、快捷、稳定的胆道结石动物模型,为临床研究探讨胆道结石成因、机制、防治方法提供可靠依据。本文归纳各种胆道结石动物模型的建立方法,就各种胆道结石动物模型建立方法及方法利弊作一综述。
Biliary calculi is a common disease,the incidence of it in China increased year by year,but the mechanism is still unknown.The selection and establishment of the ideal animal model is of great significance for studying the formation mechanism of biliary calculi.There are different ways to make animal models of biliary calculi according to the current formation mechanism of cholecystolithiasis.An efficient,fast and stable animal model of biliary calculi has been established to provide a reliable basis for clinical study of causes,mechanisms,prevention and the treatment of biliary calculi.This article summarizes a variety of methods to establish an animal model of biliary calculi and briefly reviews the pros and cons of establishing the animal model of biliary calculi.
Biliary calculi is a common disease,the incidence of it in China increased year by year,but the mechanism is still unknown.The selection and establishment of the ideal animal model is of great significance for studying the formation mechanism of biliary calculi.There are different ways to make animal models of biliary calculi according to the current formation mechanism of cholecystolithiasis.An efficient,fast and stable animal model of biliary calculi has been established to provide a reliable basis for clinical study of causes,mechanisms,prevention and the treatment of biliary calculi.This article summarizes a variety of methods to establish an animal model of biliary calculi and briefly reviews the pros and cons of establishing the animal model of biliary calculi.
引文
1 Stinton LM,Myers RP,Shaffer EA,et al.Epidemiology of gallstones[J].Gastroenterol Clin North Am,2010,39(2):157-169.
2 张中文,蒋兆彦,韩天权,等.胆石病的流行病学和危险因素[J].外科理论与实践,2011,16(4):408-411.
3 Xu GQ,Xu CF,Chen HT,et al.Association of caveolin-3 and cholecystokinin A receptor with cholesterol gallstone disease in mice[J].World J Gastroenterol,2014,20(28):9513-9518.
4 Munzberg H,Morrison CD.Structure,production and signaling of leptin[J].Metabolism,2015,64(1):13-23.
5 Vu JP,Luong L,Parsons WF,et al.Long-Term Intake of a HighProtein Diet Affects Body Phenotype,Metabolism,and Plasma Hormones in Mice[J].J Nutr,2017,147(12):2243-2251.
6 Wu X,Liang X,DU Y,et al.Prevention of gallstones by Lidan Granule:Insight into underlying mechanisms using a guinea pig model[J].Biomed Rep,2016,5(1):50-56.
7 唐乾利,黄欣,俞渊,等.环境湿度对兔胆石症模型建造的影响[J].右江民族医学院学报,2013,35(6):749-751.
8 黄洁,丁绍晖,孙敏,等.胆囊结石患者结石成分及微生物群落结构的多样性[J].世界华人消化杂志,2014,22(17):2467-2472.
9 蔡端.胆石病动物模型研究[J].上海医药,2012,33(20):3-5.
10 王训颖.胆囊结石成因及其治疗选择[J].腹部外科,1988(1):16-18.
11 徐侠,宫爱霞,方立峰.胆石病的成因及发病机制研究进展[J].现代实用医学,2012,24(4):477-480.
12 Rong ZH,Chen HY,Wang XX,et al.Effects of sphincter of Oddi motility on the formation of cholesterol gallstones[J].World J Gastroenterol,2016,22(24):5540-5547.
13 Di Ciaula A,Garruti G,Frühbeck G,et al.The Role of Diet in the Pathogenesis of Cholesterol Gallstones[J].Curr Med Chem,2017,24:1-17.
14 Kim HJ,Kim JS,Oh S,et al.Inhibition of Ceramide Decreased the Expression of ATP-Binding Cassette Transporter G5/8 mRNA in an Animal Model of Cholesterol Gallstone[J].Dig Dis,2017,35(5):439-443.
15 毛立梅,戴建华,张晏苗,等.小鼠胆囊胆固醇结石模型的建立[J].中国医药科学,2014,4(6):30-32,61.
16 李勇男,吴硕东,田雨.姜黄素在预防高脂饮食小鼠胆囊胆固醇性结石中的作用[J].肝胆胰外科杂志,2015,27(6):506-511.
17 Nakeeb A,Comuzzie AG,Martin L,et al.Gallstones:genetics versus environment[J].Ann Surg,2002,236(6):842-849.
18 周文江,许兰文,杨幼明,等.维生素C对豚鼠胆囊结石生成的影响[J].上海实验动物科学,2001,21(3):161-162.
19 希龙夫,薛荣泉,夏医君,等.瘦素在胆囊胆固醇结石形成中的作用[J].国际外科学杂志,2017,44(6):383-387.
20 蒋兆彦,韩天权,张圣道.胆囊胆固醇结石病的遗传基础[J].国外医学(消化系疾病分册),2004,24(2):111-114.
21 Lammert F,Carey MC,Paigen B.Chromosomal organization of candidate genes involved in cholesterol gallstone formation:a murine gallstone map[J].Gastroenterology,2001,120(1):221-238.
22 王文栋,王红,邓为民,等.胆结石的成因及中西药预防的研究进展[J].临床合理用药杂志,2015,8(10):174-175.
2 张中文,蒋兆彦,韩天权,等.胆石病的流行病学和危险因素[J].外科理论与实践,2011,16(4):408-411.
3 Xu GQ,Xu CF,Chen HT,et al.Association of caveolin-3 and cholecystokinin A receptor with cholesterol gallstone disease in mice[J].World J Gastroenterol,2014,20(28):9513-9518.
4 Munzberg H,Morrison CD.Structure,production and signaling of leptin[J].Metabolism,2015,64(1):13-23.
5 Vu JP,Luong L,Parsons WF,et al.Long-Term Intake of a HighProtein Diet Affects Body Phenotype,Metabolism,and Plasma Hormones in Mice[J].J Nutr,2017,147(12):2243-2251.
6 Wu X,Liang X,DU Y,et al.Prevention of gallstones by Lidan Granule:Insight into underlying mechanisms using a guinea pig model[J].Biomed Rep,2016,5(1):50-56.
7 唐乾利,黄欣,俞渊,等.环境湿度对兔胆石症模型建造的影响[J].右江民族医学院学报,2013,35(6):749-751.
8 黄洁,丁绍晖,孙敏,等.胆囊结石患者结石成分及微生物群落结构的多样性[J].世界华人消化杂志,2014,22(17):2467-2472.
9 蔡端.胆石病动物模型研究[J].上海医药,2012,33(20):3-5.
10 王训颖.胆囊结石成因及其治疗选择[J].腹部外科,1988(1):16-18.
11 徐侠,宫爱霞,方立峰.胆石病的成因及发病机制研究进展[J].现代实用医学,2012,24(4):477-480.
12 Rong ZH,Chen HY,Wang XX,et al.Effects of sphincter of Oddi motility on the formation of cholesterol gallstones[J].World J Gastroenterol,2016,22(24):5540-5547.
13 Di Ciaula A,Garruti G,Frühbeck G,et al.The Role of Diet in the Pathogenesis of Cholesterol Gallstones[J].Curr Med Chem,2017,24:1-17.
14 Kim HJ,Kim JS,Oh S,et al.Inhibition of Ceramide Decreased the Expression of ATP-Binding Cassette Transporter G5/8 mRNA in an Animal Model of Cholesterol Gallstone[J].Dig Dis,2017,35(5):439-443.
15 毛立梅,戴建华,张晏苗,等.小鼠胆囊胆固醇结石模型的建立[J].中国医药科学,2014,4(6):30-32,61.
16 李勇男,吴硕东,田雨.姜黄素在预防高脂饮食小鼠胆囊胆固醇性结石中的作用[J].肝胆胰外科杂志,2015,27(6):506-511.
17 Nakeeb A,Comuzzie AG,Martin L,et al.Gallstones:genetics versus environment[J].Ann Surg,2002,236(6):842-849.
18 周文江,许兰文,杨幼明,等.维生素C对豚鼠胆囊结石生成的影响[J].上海实验动物科学,2001,21(3):161-162.
19 希龙夫,薛荣泉,夏医君,等.瘦素在胆囊胆固醇结石形成中的作用[J].国际外科学杂志,2017,44(6):383-387.
20 蒋兆彦,韩天权,张圣道.胆囊胆固醇结石病的遗传基础[J].国外医学(消化系疾病分册),2004,24(2):111-114.
21 Lammert F,Carey MC,Paigen B.Chromosomal organization of candidate genes involved in cholesterol gallstone formation:a murine gallstone map[J].Gastroenterology,2001,120(1):221-238.
22 王文栋,王红,邓为民,等.胆结石的成因及中西药预防的研究进展[J].临床合理用药杂志,2015,8(10):174-175.