中医五行音乐治疗对试管婴儿妊娠结局的影响
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摘要
目的:探讨中医五行音乐治疗对体外受精-胚胎移植(IVF-ET)患者焦虑、抑郁情绪的缓解及对妊娠结局的促进。方法:使用抑郁自评量表(SDS)、焦虑自评量表(SAS)对行IVF-ET的患者进行调查,筛选出100例患者,采用简单随机化分组法将其分为两组,每组各50例。其中A组为中医五行音乐组,B组为空白组;实验自患者进入IVF用药周期日开始,A组每周进行1次治疗,B组不做处理,实验到移植后4周确定是否为临床妊娠时结束;对比两组干预前后SDS结果、中医症侯积分、妊娠结局。结果:干预后A组患者SDS结果显著低于B组(P<0.01),A组干预前后SDS评分差异显著(P<0.01);干预后A组患者中医症侯积分显著低于B组(P<0.05),B组SDS结果、SAS评分,中医症侯积分较前无显著差异;A组优质胚胎数、临床妊娠率较B组高,但组间比较无显著差异。结论:中医五行音乐具有改善患者焦虑、抑郁情绪的功效;中医五行音乐疗法有助于改善患者不孕症状,对提高临床妊娠率具有积极作用。
Objectives: To explore the outcome of traditional Chinese medicine and psychological treatment( TCM and five elements of music therapy) on the depression and pregnancy outcomes of IVF-ET patients.Methods: Self-rating depression scale was used to investigate IVF-ET patients. A total of 100 patients( SDS standard score≥50) were divided into two groups with 50 cases in each group. Group A was treated with TCM five elements music therapy. Group B was blank. The experiment began from patients getting into IVF cycle. The clinical pregnancy outcome was collected at 4 weeks after transplantation. Before pregnancy,patients of group A got treatment once a week. Group B received no operation. The results of SDS,quantization table for TCM syndrome differentiation and pregnancy outcomes were compared. Results: The results of SDS of group A was significantly lower than that of group B( P < 0. 01) after the intervention. The quantization for TCM syndrome differentiation of group A was significantly lower than that before intervention( P < 0. 05). Number of high quality embryos and pregnancy in group A was more than that in group B. But there was no difference between the two groups. Conclusion:TCM five elements music therapy can improve patients' depression. The effect is superior to light music and it has a positive role in promoting clinical pregnancy rate.
Objectives: To explore the outcome of traditional Chinese medicine and psychological treatment( TCM and five elements of music therapy) on the depression and pregnancy outcomes of IVF-ET patients.Methods: Self-rating depression scale was used to investigate IVF-ET patients. A total of 100 patients( SDS standard score≥50) were divided into two groups with 50 cases in each group. Group A was treated with TCM five elements music therapy. Group B was blank. The experiment began from patients getting into IVF cycle. The clinical pregnancy outcome was collected at 4 weeks after transplantation. Before pregnancy,patients of group A got treatment once a week. Group B received no operation. The results of SDS,quantization table for TCM syndrome differentiation and pregnancy outcomes were compared. Results: The results of SDS of group A was significantly lower than that of group B( P < 0. 01) after the intervention. The quantization for TCM syndrome differentiation of group A was significantly lower than that before intervention( P < 0. 05). Number of high quality embryos and pregnancy in group A was more than that in group B. But there was no difference between the two groups. Conclusion:TCM five elements music therapy can improve patients' depression. The effect is superior to light music and it has a positive role in promoting clinical pregnancy rate.
引文
[1]Doyle M,Carballedo A.Infertility and mental health,.Advances in Psychiatric Treatment,2014,20(5):297-303.
[2]李俞辰,徐慧兰,高士友.体外受精-胚胎移植妇女的焦虑、抑郁情绪.中国心理卫生杂志,2012,26(4),241-243.
[3]Khodarahimi S,Hosseinmirzaei S.Bruna MMO.The Role of Infertility in Mental Health,Psychological Distress and Sexual Dysfunction in a Sample of Iranian Women.Women&Therapy,2014,37(1-2):178-194.
[4]Liu YX,Cheng YN,Miao YL,et al.Psychological stress on female mice diminishes the developmental potential of oocytes:a study using the predatory stress model.PLo S One,2012,7(10):e480-483.
[5]Wagenmaker ER,Breen KM,Oakley AE,et al.Psychosocial stress inhibits amplitude of gonadotropin-releasing hormone pulses independent of cortisol action on the type II glucocorticoid receptor.Endocrinology,2009,150(2):762-769.
[6]Kageyama K.Regulation of gonadotropins by corticotropin-releasing factor and urocortin.Frontiers in Endocrinology,2013,4(1):12.
[7]Friedler S,Glasser S,Azani L,et al.The effect of medical clowning on pregnancy rates after in vitro fertilization and embryo transfer.Fertil Steril,2011,95(6):2127-2130.
[8]Nakayamada S,Takahashi H,Kanno Y,et al.Helper T cell diversity and plasticity.Current 0pinion in Immunology,2012,24(3):297-302.
[9]纪倩,梅旭晖,唐银杉,等.音乐电针和脉冲电针对慢性应激抑郁大鼠行为学和海马星形胶质细胞的影响.中华中医药杂志,2013,3(28):648-651.
[10]郑晨思,温丹婷,梁国荣,等.李丽芸教授治疗不孕不育的经验.时珍国医国药,2015,26(5):1228-1229.
[11]高静,弋新,吴晨曦,等.子午流注择时五行音乐疗法在慢性心力衰竭焦虑患者中的应用效果.中华护理杂志,2016,51(5):443-445.
[2]李俞辰,徐慧兰,高士友.体外受精-胚胎移植妇女的焦虑、抑郁情绪.中国心理卫生杂志,2012,26(4),241-243.
[3]Khodarahimi S,Hosseinmirzaei S.Bruna MMO.The Role of Infertility in Mental Health,Psychological Distress and Sexual Dysfunction in a Sample of Iranian Women.Women&Therapy,2014,37(1-2):178-194.
[4]Liu YX,Cheng YN,Miao YL,et al.Psychological stress on female mice diminishes the developmental potential of oocytes:a study using the predatory stress model.PLo S One,2012,7(10):e480-483.
[5]Wagenmaker ER,Breen KM,Oakley AE,et al.Psychosocial stress inhibits amplitude of gonadotropin-releasing hormone pulses independent of cortisol action on the type II glucocorticoid receptor.Endocrinology,2009,150(2):762-769.
[6]Kageyama K.Regulation of gonadotropins by corticotropin-releasing factor and urocortin.Frontiers in Endocrinology,2013,4(1):12.
[7]Friedler S,Glasser S,Azani L,et al.The effect of medical clowning on pregnancy rates after in vitro fertilization and embryo transfer.Fertil Steril,2011,95(6):2127-2130.
[8]Nakayamada S,Takahashi H,Kanno Y,et al.Helper T cell diversity and plasticity.Current 0pinion in Immunology,2012,24(3):297-302.
[9]纪倩,梅旭晖,唐银杉,等.音乐电针和脉冲电针对慢性应激抑郁大鼠行为学和海马星形胶质细胞的影响.中华中医药杂志,2013,3(28):648-651.
[10]郑晨思,温丹婷,梁国荣,等.李丽芸教授治疗不孕不育的经验.时珍国医国药,2015,26(5):1228-1229.
[11]高静,弋新,吴晨曦,等.子午流注择时五行音乐疗法在慢性心力衰竭焦虑患者中的应用效果.中华护理杂志,2016,51(5):443-445.
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