Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type arising in the pleura with pleural fibrous plaques in a lathe worker

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• 作者：Shin-ichi Nakatsuka ; MD ; PhD^a ; ^{nakatsuka@kanrou.net} ; Teruaki Nagano ; MD^a ; Hayato Kimura ; MD ; PhD^a ; Shoji Hanada ; MD^b ; Hidetoshi Inoue ; MD^b ; Takashi Iwata ; MD ; PhD^b
• 关键词：MALT lymphoma ; Pleura ; Metal ; Pneumoconiosis
• 刊名：Annals of Diagnostic Pathology
• 出版年：2012
• 期刊代码：15_10929134
• 类别：med
• 出版时间：June, 2012
• 卷：16
• 期：3
• 页码：224-229
• 文件大小：1276 K

摘要

Our patient was an 86-year-old man who had worked as a lathe operator for 40 years. He had no history of tuberculosis, pyothorax, or autoimmune disease. He had not been exposed to asbestos. He was asymptomatic, but an imaging study showed gradually increasing pleural plaques. A biopsy specimen of a pleural lesion showed sclerosis of the pleura and diffuse infiltration of small- to medium-sized B lymphocytes. Polymerase chain reaction-based analysis detected monoclonal rearrangement of immunoglobulin heavy-chain genes. Histologic diagnosis was extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type (MALT lymphoma). The lymphoma was negative for Epstein-Barr virus. We report a rare case of a metal worker with MALT lymphoma arising in the pleura with pleural fibrous plaques. It is speculated that MALT lymphoma might develop in the background of pneumoconiosis. Inflammatory and/or immunologic reactions to metal particles might contribute to the oncogenesis of this tumor.