Alzheimer鈥檚 disease: Pathogenesis and prevention

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• 作者：Heiko Braak ; ^{heiko.braak@uni-ulm.de} ; Kelly Del Tredici
• 关键词：Alzheimer&rsquo ; s disease ; AT8 ; Brain evolution ; Evolutionary medicine ; Hyperphosphorylated tau protein ; Neurofibrillary tangles ; Neuropil threads ; Pretangles ; Myelination
• 刊名：Alzheimer's Dementia
• 出版年：2012
• 期刊代码：6_15525260
• 类别：med
• 出版时间：May, 2012
• 卷：8
• 期：3
• 页码：227-233
• 文件大小：904 K

摘要

Tau lesions (pretangles, neuropil threads, neurofibrillary tangles) in select neuronal types are essential to the pathogenesis of Alzheimer鈥檚 disease. Pretangle formation marks the beginning of the pathological process and is of particular interest because it is temporally closer to the prevailing conditions that induce the pathological process underlying Alzheimer鈥檚 disease in contrast to late-stage disease. However, not all pretangles convert into neurofibrillary tangles. We propose that the development of tau lesions in Alzheimer鈥檚 disease is traceable to differences between early- versus late-maturing oligodendrocytes and to the exceptionally protracted myelination of late-developing portions of the human brain. Conclusions drawn from these considerations should encourage development of new preventative and disease-modifying strategies.