Patterns of antituberculous drug resistance in Eastern Saudi Arabia: A 7-year surveillance study from 1/2003 to 6/2010

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• 作者：Liaqat Ali Chaudhry^a ; ^{dr_liaqatali@hotmail.com} ; Nagamani Rambhala^b ; Ali Saad Al-Shammri^c ; Jaffar A. Al-Tawfiq^d
• 关键词：MDR-TB ; multi-drug resistance tuberculosis ; SDR-TB ; single drug resistance tuberculosis ; NTBCP ; national tuberculosis control program ; DST ; drug sensitivity test
• 刊名：Journal of Epidemiology and Global Health
• 出版年：2012
• 期刊代码：pca220_22106006
• 类别：med
• 出版时间：March, 2012
• 卷：2
• 期：1
• 页码：57-60
• 文件大小：157 K

摘要

Objective

To examine the patterns of antituberculous drug resistance of Mycobacterium tuberculosis in patients with pulmonary and extra-pulmonary tuberculosis in the Eastern province of the Kingdom of Saudi Arabia.

Methods

This is a retrospective study of antibiotic susceptibility of 1681 non-repetitive M. tuberculosis isolates from 1/2003 to 6/2010.

Results

Of the total patients, 41%(n = 687) were Saudis and 59%(n = 994) were non-Saudis. The pulmonary and extra-pulmonary specimens constituted 68%(n = 1148) and 32%(n = 533), respectively. The incidence of resistance was 15.5%to one or more of anti-tuberculosis drugs. The resistance rates to first-line drugs were as follows: streptomycin (10.4%), INH (9.8%), rifampicin (1.5%) and ethambutol (1.0%). Multi-drug resistant tuberculosis was present in 1.4%(n = 24) of the sample.

Conclusion

INH resistance in this study was relatively high, whereas the rate of MDR-TB was low. A rate of MDR-TB observed in this study was 1.4%. Thus, an empiric four-drug therapy is required to treat patients with tuberculosis in this area of Saudi Arabia.