Artesunate–erythropoietin combination for murine cerebral malaria treatment

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• 作者：Anne-Lise Bienvenu ; Josette Ferr ; iz ; Karine Kaiser ; Christine Latour ; Sté ; phane Picot
• 关键词：Cerebral malaria ; Erythropoietin ; Artesunate ; Adjunctive therapy ; Plasmodium berghei ANKA
• 刊名：Acta Tropica
• 出版年：2008
• 期刊代码：2_0001706x
• 类别：imm
• 出版时间：May 2008
• 卷：106
• 期：2
• 页码：104-108
• 文件大小：456 K

摘要

Cerebral malaria is the most severe and rapidly fatal complication of Plasmodium falciparum infection. Despite appropriate anti-malarial treatment using quinine or artemisinin derivatives, 10–20%of mortality still occurs during the acute phase. To improve cerebral malaria outcome, adjunctive therapies are clearly needed. Most experiments in this area have been dedicated to immuno-modulation with various successes. Since erythropoietin has been shown to be highly effective in human ischemic stroke and in murine cerebral malaria, we addressed the issue of cerebral malaria outcome improvement by erythropoietin–artesunate drug combination. Compared to the previous study using erythropoietin high doses at the early beginning of the disease, erythropoietin treatment was decreased by six-fold and delayed to the pre-mortem phase.