Chemoenzymatic synthesis and in vitro studies on the hydrolysis of antimicrobial monoglycosyl diglycerides by pancreatic lipase

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• 作者：Francesca Cateni ; Paolo Bonivento ; Giuseppe Procida ; Marina Zacchigna ; Giuditta Scialino ; Elena Banfi
• 关键词：Synthesis ; Monoglycosyl diglycerides ; 1 ; 2-Di-O-acyl-3-O-β ; -d-glucopyranosyl-glycerols ; 1 ; 2-Di-O-acyl-3-O-β ; -d-galactopyranosyl-glycerols ; Antimicrobial activity ; Pancreatic lipase
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2007
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：1 April 2007
• 卷：17
• 期：7
• 页码：1971-1978
• 文件大小：179 K

摘要

Monoglucosyl and monogalactosyl diglycerides (MGDGs) with medium-long length acyl chains, identified as active components in Euphorbiaceae, were synthesized. They were examined for antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. MGDGs with two octanoyl groups at both 1- and 2-positions showed the most potent activity. The stereoselectivity of pancreatic lipase was investigated in vitro where the preference for the 1 position in MGDGs is strictly related to the length of the acyl chains.