Alkaloids from an algicolous strain of Talaromyces sp.

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• 作者：Haibin Yang 杨海湿/a> ; Fang Li 李昉 ; Naiyun Ji 季乃丿/a>
• 关键词：Talaromyces sp. ; alkaloid ; chiral separation ; quantum chemical calculation ; bioactivity
• 刊名：Chinese Journal of Oceanology and Limnology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：34
• 期：2
• 页码：367-371
• 全文大小：545 KB
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• 作者单位：Haibin Yang 杨海滨 (1) (2)
  Fang Li 李昉 (1)
  Naiyun Ji 季乃云 (2)
  
  1. College of Chemistry and Molecular Engineering, Qingdao University of Science & Technology, Qingdao, 266042, China
  2. Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, 264003, China
  
• 刊物主题：Oceanography;
• 出版者：Springer Berlin Heidelberg
• ISSN：1993-5005

文摘

Compounds isolated and identified in a culture of the alga-endophytic fungus Talaromyces sp. cf-16 included two naturally occurring alkaloids, 2-[(S)-hydroxy(phenyl)methyl]-3-methylquinazolin-4(3H)-one (1a) and 2-[(R)-hydroxy(phenyl)methyl]-3-methylquinazolin-4(3H)-one (1b), that were identified for the first time. In addition, seven known compounds (2–8) were obtained from the culture. Following chiral column chromatography, compounds 1a and 1b were identified as enantiomers by spectroscopic analyses and quantum chemical calculations. Bioassay results showed that 5 was more toxic to brine shrimp than the other compounds, and that 3–6 could inhibit Staphylococcus aureus.