Synthesis and Characterization of Novel Blood-Compatible Soluble Chemically Cross-Linked Polyurethanes with Excellent Mechanical Performance for Biomedical Applications

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• 作者：Zunfeng Liu ; Xiang Wu ; Xiaoying Yang ; Dongping Liu ; Chen Jun ; Ruimin Sun ; Xueping Liu ; and Fangxing Li
• 刊名：Biomacromolecules
• 出版年：2005
• 出版时间：May 2005
• 年：2005
• 卷：6
• 期：3
• 页码：1713 - 1721
• 全文大小：409K
• 年卷期：v.6,no.3(May 2005)
• ISSN：1526-4602

文摘

A controlled cross-linking polymerization system was designed, and soluble chemically cross-linkedpolyurethane was synthesized using laurylamine, n-octylamine, n-pentylamine, and ethylenediamine chainextenders. The mechanical analysis showed that the polyurethane materials synthesized in this paper havevery excellent mechanical properties with a breaking elongation of 1914% and a tensile strength of 4303N/cm². Such good mechanical properties must enable it to have good longevity when used as biomaterials.The polyurethane materials with n-pentylamine and n-octylamine chain extenders show reduced plateletadhesion than that with an ethylenediamine chain extender after sustaining 200 000 times of load cycles,indicating that polyurethanes introduced with an alkyl side chain onto the hard segments keep goodantithrombogenic properties after sustaining load cycles. This might be because the hard segments are shieldedby the alkyl side chain when the micro-phase-separation structure is destroyed in the repeated deformationof the polyurethane materials. The present investigation reveals that the influence of introducing long alkylside chains into the backbone of the polyurethane macromolecule has been shown to reduce platelet depositionand to enhance in vitro albumin adsorption. However, in this paper, it has been observed that the polyurethanematerial introduced with a proper-length alkyl side chain onto the hard segment has the best antithrombogenicproperties after the fatigue test.