Step-Controlled Povarov-Type Reaction with 1,2-Dihydroquinolines as Precursors of Dienophiles: Direct Synthesis of Spirocyclic Bi-tetrahydroquinolines and Functionalized 1,2-Dihydroquinolines

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• 作者：Xuwen Ren ; Guangxun LiJin Huang ; Weidong Wang ; Yongpo Zhang ; Guomin Xing ; Chunyan Gao ; Gang Zhao ; Jinzhong Zhao ; Zhuo Tang
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：January 6, 2017
• 年：2017
• 卷：19
• 期：1
• 页码：58-61
• 全文大小：386K
• ISSN：1523-7052

文摘

A novel Povarov-type reaction for straightforward synthesis of novel spiro bi-tetrahydroquinolines with readily available 1,2-DHQs (1,2-dihydroquinolines) and aromatic imines was developed. The reaction could be selectively stopped at the first stage under a Brønsted acid catalyst to afford the corresponding functionalized 1,2-DHQs conveniently.