Nickel-Catalyzed Stereoselective Alkenylation of C(sp3)–H Bonds with Terminal Alkynes

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• 作者：Cong Lin ; Zhengkai Chen ; Zhanxiang Liu ; Yuhong Zhang
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：February 17, 2017
• 年：2017
• 卷：19
• 期：4
• 页码：850-853
• 全文大小：407K
• ISSN：1523-7052

文摘

A nickel-catalyzed stereoselective alkenylation of an unactivated β-C(sp³)–H bond in aliphatic amide with terminal alkynes using 8-aminoquinoline auxiliary is reported for the first time. This reaction displays excellent functional group tolerance with respect to both aliphatic amides and terminal alkynes and features a cheap nickel catalytic system. The 8-aminoquinolyl directing group could be smoothly removed, and the resultant β-styrylcarboxylic acid derivatives could serve as versatile building blocks for further transformation.