Copper-Catalyzed Three-Component Coupling Reaction of Azoles, Se Powder, and Aryl Iodides

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• 作者：Chao Gao ; Ge Wu ; Lin Min ; Miaochang Liu ; Wenxia Gao ; Jinchang Ding ; Jiuxi ChenXiaobo Huang ; Huayue Wu
• 刊名：Journal of Organic Chemistry
• 出版年：2017
• 出版时间：January 6, 2017
• 年：2017
• 卷：82
• 期：1
• 页码：250-255
• 全文大小：381K
• ISSN：1520-6904

文摘

A copper-catalyzed three-component coupling reaction of azoles, Se powder, and aryl iodide is described for the first time. This transformation provides a straightforward and facile pathway to synthesis 2-arylselanyl-azoles via a copper-catalyzed double C–Se bonds formation process. This reaction is attractive and practical since the cheap copper catalyst is employed and it does not require ligands, proceeds in generally good yields, and has a broad range of functional groups tolerance.