Palladium-Catalyzed Synthesis of Indoles and Isoquinolines with in Situ Generated Phosphinimine

详细信息    查看全文

• 作者：Qi Zhou ; Zhikun Zhang ; Yujing Zhou ; Shichao Li ; Yan Zhang ; Jianbo Wang
• 刊名：Journal of Organic Chemistry
• 出版年：2017
• 出版时间：January 6, 2017
• 年：2017
• 卷：82
• 期：1
• 页码：48-56
• 全文大小：549K
• ISSN：1520-6904

文摘

A palladium-catalyzed synthesis of polysubstituted indoles and isoquinolines through the coupling of aryl bromides with 2-alkynyl arylazides or 2-alkynyl benzylazides has been developed. This method provides straightforward access to indoles and isoquinolines with high efficiency and excellent functional group compatibility. In this transformation, the iminophosphorane in situ generated from azides is served as the nucleophile that attacks the alkyne moiety in the cyclization process.