Investigation of Phase Behavior and Thermodynamic Stability in Kolliphor HS 15/Caprylic/Capric Triglycerides (GTCC)/Water Microemulsions System

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• 作者：Wen-ting WangJiao-jiao Wu ; Dan Li ; Hong Liu ; Hong-chun Pan
• 刊名：Journal of Chemical & Engineering Data
• 出版年：2017
• 出版时间：January 12, 2017
• 年：2017
• 卷：62
• 期：1
• 页码：303-309
• 全文大小：430K
• ISSN：1520-5134

文摘

Phase behavior of microemulsions composed of Kolliphor HS 15, caprylic/capric triglycerides (GTCC), and water was investigated by phase diagrams and conductivity measurements. In addition, ΔG_CP⁰, ΔH_CP⁰, and ΔS_CP⁰ were also calculated because the clouding phenomenon is controlled by energy. On the basis of the preliminary contribution to the variation of both specific conductance and peak current, the monophasic phase could be divided into self-microemulsion and microemulsion regions. Besides, a shorter bicontinuous phase was formed as the composition closing to the boundary between two subregions. Furthermore, thermodynamic parameter showed that self-microemulson was more stable than that of microemulsion, which was further supported by cyclic voltammetry characterizing the two subregions. Dehydration of solvation layer as α_GTCC increasing is responsible for the mechanism of the liquid–liquid phase separation process and therefore of the thermodynamic stability.