Pharmacokinetics and Biodistribution of the Illegal Food Colorant Rhodamine B in Rats

详细信息    查看全文

• 作者：Yung-Yi ChengTung-Hu Tsai
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2017
• 出版时间：February 8, 2017
• 年：2017
• 卷：65
• 期：5
• 页码：1078-1085
• 全文大小：328K
• ISSN：1520-5118

文摘

The International Agency for Research on Cancer (IARC) demonstrated rhodamine B as a potential carcinogen in 1978. Nevertheless, rhodamine B has been illegally used as a colorant in food in many countries. Few pharmacokinetic and toxicological investigations have been performed since the first pharmacokinetic study on rhodamine B in 1961. The aims of this study were to develop a simple and sensitive high-performance liquid chromatography method with fluorescence detection for the quantitative detection of rhodamine B in the plasma and organs of rats and to estimate its pharmacokinetics and biodistribution. The results demonstrated that the oral bioavailabilities of rhodamine B were 28.3 and 9.8% for the low-dose and high-dose exposures, respectively. Furthermore, rhodamine B was highly accumulated in the liver and, to a lesser extent, the kidney, but was undetectable in the brain. These results provide useful information for improving the pharmacokinetics and biodistribution of rhodamine B, supporting additional food safety evaluations.