Quantitative Analysis of Multicomponent Mixtures of Over-the-Counter Pain Killer Drugs by Low-Field NMR Spectroscopy

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• 作者：Aleksandra ZivkovicJan Josef Bandolik ; Alexander Jan Skerhut ; Christina Coesfeld ; Momir Prascevic ; Ljiljana Zivkovic ; Holger Stark
• 刊名：Journal of Chemical Education
• 出版年：2017
• 出版时间：January 10, 2017
• 年：2017
• 卷：94
• 期：1
• 页码：121-125
• 全文大小：286K
• ISSN：1938-1328

文摘

Marketed pain relief drugs with one to three biologically active components, as well as mixtures of these ingredients, were qualitatively and quantitatively analyzed in an undergraduate student lab using a compact, low-field ¹H NMR spectrometer. The students successfully analyzed more than 50 self-made sample mixtures with two or three components as well as the two marketed tablet formulations containing acetylsalicylic acid/mallcaps">l-ascorbic acid, or acetylsalicylic acid/paracetamol (acetaminophen)/caffeine. The NMR-based quantification is an attractive application of the technique, as well as a helpful introduction to NMR spectroscopic applications in life sciences. Problem-based learning on NMR techniques on commonly known drugs provided students the opportunity to develop and improve their skills in solving ¹H NMR problems.