1,3-Dien-5-ynes: Versatile Building Blocks for the Synthesis of Carbo- and Heterocycles

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• 作者：Enrique Aguilar ; Roberto Sanz ; Manuel A. Fernández-Rodríguez ; Patricia García-García
• 刊名：Chemical Reviews
• 出版年：2016
• 出版时间：July 27, 2016
• 年：2016
• 卷：116
• 期：14
• 页码：8256-8311
• 全文大小：4514K
• 年卷期：0
• ISSN：1520-6890

文摘

1,3-Dien-5-ynes have been extensively used as starting materials for the synthesis of a wide number of different carbo- and heterocycles. The aim of this review is to give an overview of their utility in organic synthesis, highlighting the variety of compounds that can be directly accessed from single reactions over these systems. Thus, cycloaromatization processes are initially commented, followed by reactions directed toward the syntheses of five-membered rings, other carbocycles and, finally, heterocycles. The diverse methodologies that have been developed for the synthesis of each of these types of compounds from 1,3-dien-5-ynes are presented, emphasizing the influence of the reaction conditions and the use of additional reagents in the outcome of the transformations.