N-Iodosuccinimide-Promoted Cascade Trifunctionalization of Alkynoates: Access to 1,1-Diiodoalkenes

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• 作者：Shengyang Ni ; Wanxing Sha ; Lijun Zhang ; Chen Xie ; Haibo Mei ; Jianlin Han ; Yi Pan
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：February 19, 2016
• 年：2016
• 卷：18
• 期：4
• 页码：712-715
• 全文大小：357K
• ISSN：1523-7052

文摘

An efficient cascade trifunctioalization reaction of alkynoates with N-iodosuccinimide has been developed which proceeds through iodination, aryl migration, decarboxylation, and second iodination. This reaction represents an example of 1,1-difunctionalization of the acetylene bond and also provides a new strategy for the preparation of 1,1-diiodoalkenes.